AXELOPRAN
Axelopran is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Clinical
Clinical Trials
7 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Constipation | D003248 | — | K59.0 | 1 | 3 | — | — | — | 4 |
| Opioid-induced constipation | D000079689 | — | — | 1 | 4 | — | — | — | 4 |
| Healthy volunteers/patients | — | — | — | 2 | 1 | — | — | — | 2 |
Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | AXELOPRAN |
| INN | axelopran |
| Description | Axelopran (INN, USAN) (developmental code name TD-1211) is a drug which is under development by Theravance Biopharma and licensed to Glycyx for all indications. It acts as a peripherally acting μ-opioid receptor antagonist and also acts on κ-, and δ-opioid receptors, with similar affinity for the μ- and κ-opioid receptors and about an order of magnitude lower affinity for the δ-opioid receptor. Recent data suggests that μ-opioid antagonists have a direct effect on overall survival in patients with advanced cancer.
|
| Classification | Small molecule |
| Drug class | opioid receptor antagonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NC(=O)c1cccc([C@@H]2C[C@@H]3CC[C@H](C2)N3CCN(CC2CCCCC2)C(=O)[C@@H](O)CO)c1 |
Identifiers
| PDB | — |
| CAS-ID | 949904-48-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3137313 |
| ChEBI ID | — |
| PubChem CID | 67156338 |
| DrugBank | — |
| UNII ID | 85U7ROB149 (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
PubMed Central
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Additional graphs summarizing 14 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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