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Drug ReportsAXELOPRAN
AXELOPRAN
Axelopran is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
No data
Clinical
Clinical Trials
7 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
ConstipationD003248K59.0245
Opioid-induced constipationD000079689144
Healthy volunteers/patients212
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameAXELOPRAN
INNaxelopran
Description
Axelopran (INN, USAN) (developmental code name TD-1211) is a drug which is under development by Theravance Biopharma and licensed to Glycyx for all indications. It acts as a peripherally acting μ-opioid receptor antagonist and also acts on κ-, and δ-opioid receptors, with similar affinity for the μ- and κ-opioid receptors and about an order of magnitude lower affinity for the δ-opioid receptor. Recent data suggests that μ-opioid antagonists have a direct effect on overall survival in patients with advanced cancer.
Classification
Small molecule
Drug classopioid receptor antagonists
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Structure (InChI/SMILES or Protein Sequence)
NC(=O)c1cccc([C@@H]2C[C@@H]3CC[C@H](C2)N3CCN(CC2CCCCC2)C(=O)[C@@H](O)CO)c1
Identifiers
PDB
CAS-ID949904-48-7
RxCUI
ChEMBL IDCHEMBL3137313
ChEBI ID
PubChem CID67156338
DrugBank
UNII ID85U7ROB149 (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 14 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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