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Company ReportsKiniksa Pharmaceuticals

Kiniksa Pharmaceuticals(KNSA)

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Trade Name	Drug Name	Approved	Patent Expires	Indication
Arcalyst	Rilonacept	2008-02-27		Inborn genetic diseases , Inflammation , Cryopyrin-associated periodic syndromes

Clinical Trials

Therapeutic Areas:

All

Classification:

All

Approval:

All

Status:

All

Phases:

All

Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

,

healthy volunteers/patients

,

rheumatoid arthritis

,

,

respiratory insufficiency

,

severe acute respiratory syndrome-related coronavirus

,

,

,

respiratory distress syndrome

,

viral pneumonia

,

giant cell arteritis

,

,

,

,

myelodysplastic syndromes

,

myeloid leukemia acute

,

non-hodgkin lymphoma

,

multiple myeloma

,

,

precursor cell lymphoblastic leukemia-lymphoma

,

b-cell chronic lymphocytic leukemia

,

bcr-abl positive chronic myelogenous leukemia

,

hodgkin disease

,

t-cell lymphoma peripheral

,

myeloid leukemia

,

lymphoid leukemia

aids-related complex

,

,

ovarian neoplasms

,

,

central nervous system neoplasms

,

germ cell and embryonal neoplasms

,

liver neoplasms

,

nervous system neoplasms

,

non-hodgkin lymphoma

,

,

multiple myeloma

,

,

,

plasma cell neoplasms

,

hodgkin disease

,

,

acquired immunodeficiency syndrome

,

,

myeloid leukemia acute

,

myeloid leukemia

,

,

,

,

non-small-cell lung carcinoma

,

prostatic neoplasms

,

,

urinary bladder neoplasms

,

transitional cell carcinoma

,

,

,

type 1 diabetes mellitus

,

smoldering multiple myeloma

,

myeloproliferative disorders

,

hematologic diseases

,

aplastic anemia

,

,

,

breast neoplasms

,

,

precursor cell lymphoblastic leukemia-lymphoma

,

lymphoid leukemia

,

myelodysplastic syndromes

,

,

,

,

graft vs host disease

,

b-cell lymphoma

healthy volunteers/patients

,

,

bcr-abl positive chronic myelogenous leukemia

,

type 2 diabetes mellitus

,

glandular and epithelial neoplasms

,

,

gata2 deficiency

,

central nervous system neoplasms

,

,

fallopian tube diseases

,

neurologic manifestations

,

,

interdigitating dendritic cell sarcoma

,

myeloproliferative disorders

,

neoplasms by histologic type

,

adenosquamous carcinoma

,

chronic hepatitis c

,

,

venous thromboembolism

,

thromboembolism

,

pharmacokinetics

,

,

behcet syndrome

,

aids-related complex

,

pleural effusion

,

respiratory tract neoplasms

,

bronchogenic carcinoma

,

thoracic neoplasms

,

malignant pleural effusion

,

pleural diseases

,

pleural neoplasms

,

immunosuppression therapy

,

small cell lung carcinoma

,

transitional cell carcinoma

,

ovarian neoplasms

,

non-hodgkin lymphoma

,

triple negative breast neoplasms

,

urologic neoplasms

,

squamous cell carcinoma

,

,

biliary tract neoplasms

,

malignant mesothelioma

,

large b-cell lymphoma diffuse

,

,

uterine cervical neoplasms

,

neoplasms by site

,

castration-resistant prostatic neoplasms

,

b-cell lymphoma

,

endometrial neoplasms

,

,

squamous cell neoplasms

,

,

uveal neoplasms

,

,

hematologic neoplasms

,

t-cell lymphoma peripheral

,

t-cell lymphoma

,

b-cell chronic lymphocytic leukemia

,

,

neuroendocrine tumors

,

gastrointestinal neoplasms

,

adenocarcinoma of lung

,

myeloid leukemia acute

,

cholangiocarcinoma

,

graft vs host disease

,

interstitial lung diseases

,

follicular lymphoma

,

merkel cell carcinoma

,

peritoneal neoplasms

,

spinocerebellar degenerations

,

,

graft rejection

,

psychology rejection

,

clear cell adenocarcinoma

,

,

,

medulloblastoma

,

,

,

rhabdomyosarcoma

,

diffuse intrinsic pontine glioma

,

,

autoimmune diseases

,

multiple sclerosis

,

waldenstrom macroglobulinemia

,

extranodal nk-t-cell lymphoma

,

precursor cell lymphoblastic leukemia-lymphoma

,

burkitt lymphoma

,

female genital neoplasms

,

endometrioid carcinoma

,

,

,

urogenital neoplasms

,

organ transplantation

,

neuroendocrine carcinoma

,

urinary bladder diseases

,

microsatellite instability

,

basal cell carcinoma

,

basal cell neoplasms

,

diffuse scleroderma

,

laryngeal diseases

,

,

heart transplantation

,

,

male breast neoplasms

,

b-cell leukemia

,

tertiary lymphoid structures

,

oropharyngeal neoplasms

,

,

prostatic diseases

,

non-muscle invasive bladder neoplasms

,

nasopharyngeal carcinoma

,

nasopharyngeal neoplasms

,

diabetic neuropathies

,

nephrotic syndrome

,

focal segmental glomerulosclerosis

,

lipoid nephrosis

,

bronchiolitis obliterans syndrome

,

diabetic nephropathies

,

kidney diseases

,

common variable immunodeficiency

,

large-cell lymphoma anaplastic

,

,

phenylketonurias

,

bile duct neoplasms

,

serous cystadenocarcinoma

,

papillary thyroid cancer

,

,

salivary gland neoplasms

,

genetic therapy

,

smoldering multiple myeloma

,

uterine neoplasms

,

large cell carcinoma

,

endometrial stromal tumors

,

small cell carcinoma

,

penile neoplasms

,

adrenocortical carcinoma

,

digestive system diseases

,

,

,

,

,

invasive hydatidiform mole

,

,

,

,

bronchiolo-alveolar adenocarcinoma

,

drug-related side effects and adverse reactions

,

carcinoid tumor

,

hypersensitivity

,

thyroid neoplasms

,

precancerous conditions

,

bronchopulmonary dysplasia

,

tobacco smoking

,

b-cell lymphoma marginal zone

,

mantle-cell lymphoma

,

meningeal carcinomatosis

,

systemic scleroderma

,

patient preference

,

,

oral leukoplakia

,

churg-strauss syndrome

,

microscopic polyangiitis

,

oligodendroglioma

,

myeloid leukemia

,

,

,

ankylosing spondylitis

,

,

inflammatory breast neoplasms

,

immunoglobulin g4-related disease

,

,

,

progressive multifocal leukoencephalopathy

,

gastrointestinal stromal tumors

,

male urogenital diseases

,

female urogenital diseases

,

female urogenital diseases and pregnancy complications

,

urogenital diseases

,

reactive arthritis

,

hereditary nonpolyposis colorectal neoplasms

,

,

aplastic anemia

,

,

,

non-small-cell lung carcinoma

,

colorectal neoplasms

,

neoplasm metastasis

,

squamous cell carcinoma of head and neck

,

prostatic neoplasms

,

head and neck neoplasms

,

breast neoplasms

,

pancreatic neoplasms

,

liver neoplasms

,

hepatocellular carcinoma

,

urinary bladder neoplasms

,

,

brain neoplasms

,

stomach neoplasms

,

hodgkin disease

,

multiple myeloma

,

,

colonic neoplasms

,

,

rectal neoplasms

,

esophageal neoplasms

,

,

,

,

cutaneous malignant melanoma

,

pancreatic ductal carcinoma

,

fallopian tube neoplasms

,

systemic lupus erythematosus

,

myelodysplastic syndromes

,

plasma cell neoplasms

,

,

ovarian epithelial carcinoma

,

,

,

esophageal squamous cell carcinoma

,

ulcerative colitis

,

juvenile arthritis

,

psoriatic arthritis

,

sjogren's syndrome

,

,

,

lupus nephritis

,

giant cell arteritis

,

respiratory tract diseases

,

granulomatosis with polyangiitis

,

anti-neutrophil cytoplasmic antibody-associated vasculitis

,

hyperlipidemias

,

polymyalgia rheumatica

,

vascular diseases

,

,

systemic vasculitis

,

disease progression

,

pathologic complete response

,

,

rheumatoid arthritis

,

renal cell carcinoma

,

,

,

kidney transplantation

,

acquired immunodeficiency syndrome

,

,

kidney neoplasms

,

delayed graft function

,

chronic kidney failure

,

coronary artery disease

,

,

hiv-associated lipodystrophy syndrome

,

epstein-barr virus infections

,

,

transplantation

,

mitochondrial diseases

,

,

,

parkinson disease

,

,

cardiomyopathies

,

dilated cardiomyopathy

,

,

,

alzheimer disease

,

progressive supranuclear palsy

,

,

,

diabetes mellitus

,

ulcerative colitis

,

,

,

chronic urticaria

,

,

neurodermatitis

,

,

systemic scleroderma

,

idiopathic pulmonary fibrosis

,

gastrointestinal diseases

,

inflammatory bowel diseases

,

Bos taurus adrenal cortex corticosteroids

,

multiple sclerosis

,

relapsing-remitting multiple sclerosis

,

,

chronic obstructive pulmonary disease

,

,

obstructive lung diseases

,

,

parkinson disease

,

,

,

large-cell lymphoma anaplastic

,

,

,

neoplasms by histologic type

,

neoplasms by site

,

plasma cell leukemia

,

optic nerve glioma

,

primitive neuroectodermal tumors peripheral

,

immunoblastic lymphadenopathy

,

precursor t-cell lymphoblastic leukemia-lymphoma

,

basal cell carcinoma

,

basal cell neoplasms

,

human influenza

,

brain stem neoplasms

,

cerebrotendinous xanthomatosis

,

stem cell transplantation

,

adenocarcinoma of lung

,

,

precancerous conditions

,

smoldering multiple myeloma

,

mycobacterium avium-intracellulare infection

,

mycobacterium infections

,

,

carcinoid tumor

,

healthy volunteers/patients

,

,

respiratory syncytial virus infections

,

cystic fibrosis

,

,

phenylketonurias

,

myasthenia gravis

,

myelomonocytic leukemia juvenile

,

pancreatic ductal carcinoma

,

conjunctival neoplasms

,

clear cell sarcoma

,

gastrointestinal stromal tumors

,

salivary gland neoplasms

,

testicular neoplasms

,

medullary carcinoma

,

thrombocytopenia

,

paroxysmal hemoglobinuria

,

aids-related complex

,

,

parkinsonian disorders

,

pharmacokinetics

,

pseudomyxoma peritonei

,

,

ovarian neoplasms

,

colorectal neoplasms

,

,

b-cell chronic lymphocytic leukemia

,

myeloid leukemia

,

non-small-cell lung carcinoma

,

,

,

myeloproliferative disorders

,

kidney neoplasms

,

mantle-cell lymphoma

,

cutaneous malignant melanoma

,

fallopian tube neoplasms

,

central nervous system neoplasms

,

hodgkin disease

,

,

male breast neoplasms

,

lymphoid leukemia

,

burkitt lymphoma

,

large-cell lymphoma immunoblastic

,

liver neoplasms

,

,

stomach neoplasms

,

ovarian epithelial carcinoma

,

colonic neoplasms

,

medulloblastoma

,

hepatocellular carcinoma

,

myelodysplastic-myeloproliferative diseases

,

oligodendroglioma

,

,

,

b-cell lymphoma marginal zone

,

nervous system neoplasms

,

respiratory distress syndrome

,

b-cell lymphoma

,

rectal neoplasms

,

malignant mesothelioma

,

,

myeloid leukemia accelerated phase

,

myelomonocytic leukemia chronic

,

,

,

diffuse intrinsic pontine glioma

,

hematologic neoplasms

,

squamous cell carcinoma

,

small cell lung carcinoma

,

,

rheumatoid arthritis

,

,

t-cell lymphoma cutaneous

,

,

primitive neuroectodermal tumors

,

castration-resistant prostatic neoplasms

,

alzheimer disease

,

endometrial neoplasms

,

drug-related side effects and adverse reactions

,

peripheral arterial disease

,

ductal carcinoma breast

,

uterine cervical neoplasms

,

intraductal carcinoma noninfiltrating

,

squamous cell carcinoma of head and neck

,

refractory anemia

,

alveolar soft part sarcoma

,

inflammatory breast neoplasms

,

nasopharyngeal carcinoma

,

aplastic anemia

,

,

t-cell lymphoma peripheral

,

,

intestinal neoplasms

,

sezary syndrome

,

waldenstrom macroglobulinemia

,

mycosis fungoides

,

interdigitating dendritic cell sarcoma

,

glandular and epithelial neoplasms

,

endometrioid carcinoma

,

,

merkel cell carcinoma

,

squamous cell neoplasms

,

subependymal glioma

,

germ cell and embryonal neoplasms

,

esophageal neoplasms

,

peritoneal neoplasms

,

neuroendocrine tumors

,

islet cell adenoma

,

severe acute respiratory syndrome

,

acute lung injury

,

newborn respiratory distress syndrome

,

respiratory aspiration

,

transitional cell carcinoma

,

cholangiocarcinoma

,

gallbladder neoplasms

,

residual neoplasm

,

nasopharyngeal neoplasms

,

gastrointestinal neoplasms

,

immunologic deficiency syndromes

,

t-cell lymphoma

,

immunoglobulin light-chain amyloidosis

,

,

pulmonary hypertension

,

systemic scleroderma

,

interstitial lung diseases

,

diffuse scleroderma

,

lymphoproliferative disorders

,

extranodal nk-t-cell lymphoma

,

primary myelofibrosis

,

prolymphocytic leukemia

,

,

thymus neoplasms

,

biliary tract neoplasms

,

,

mucinous cystadenocarcinoma

,

serous cystadenocarcinoma

,

cystadenocarcinoma

,

,

animal mammary neoplasms

,

,

basophilic leukemia acute

,

eosinophilic leukemia acute

,

,

neuroectodermal tumors

,

cognitive dysfunction

,

,

severe acute respiratory syndrome-related coronavirus

,

,

unilateral breast neoplasms

,

kidney diseases

,

kidney transplantation

,

urogenital neoplasms

,

prostatic diseases

,

male genital neoplasms

,

critical illness

,

immunosuppression therapy

,

,

trophoblastic neoplasms

,

,

,

vascular diseases

,

atherosclerosis

,

intermittent claudication

,

pneumococcal pneumonia

,

,

bile duct neoplasms

,

laryngeal neoplasms

,

,

urologic neoplasms

,

,

,

,

,

soft tissue neoplasms

,

,

,

breast neoplasms

,

prostatic neoplasms

,

multiple myeloma

,

myelodysplastic syndromes

,

non-hodgkin lymphoma

,

plasma cell neoplasms

,

,

bcr-abl positive chronic myelogenous leukemia

,

follicular lymphoma

,

pancreatic neoplasms

,

,

,

large b-cell lymphoma diffuse

,

,

pulmonary alveolar proteinosis

,

neoplasm metastasis

,

brain neoplasms

,

renal cell carcinoma

,

,

myeloid leukemia chronic-phase

,

triple negative breast neoplasms

,

,

acquired immunodeficiency syndrome

,

uveal neoplasms

,

rhabdomyosarcoma

,

,

,

,

congenital abnormalities

,

head and neck neoplasms

,

ganglioneuroblastoma

,

,

,

,

megakaryoblastic leukemia acute

,

monocytic leukemia acute

,

myelomonocytic leukemia acute

,

erythroblastic leukemia acute

,

urinary bladder neoplasms

,

graft vs host disease

,

refractory anemia with excess of blasts

,

communicable diseases

,

,

hematologic diseases

,

,

radiation effects

,

pathologic complete response

,

alveolar rhabdomyosarcoma

,

embryonal rhabdomyosarcoma

,

cytomegalovirus retinitis

,

,

cutaneous leishmaniasis

,

,

coronavirus infections

,

,

,

invasive fungal infections

,

,

tongue neoplasms

,

,

,

,

myeloid leukemia acute

,

,

precursor cell lymphoblastic leukemia-lymphoma

,

,

,

,

chronic hepatitis b

,

,

,

,

multiple organ failure

,

,

respiratory insufficiency

,

wounds and injuries

,

liver cirrhosis

,

,

,

graft rejection

,

,

periodontal diseases

,

,

,

,

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