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Company ReportsKaryopharm Therapeutics

Karyopharm Therapeutics(KPTI)

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Trade Name	Drug Name	Approved	Patent Expires	Indication
Xpovio	Selinexor	2019-07-03	2032-2035	Multiple myeloma

Clinical Trials

Therapeutic Areas:

All

Classification:

All

Approval:

All

Status:

All

Phases:

All

Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

neoplasm metastasis

,

biphenotypic leukemia acute

,

precursor cell lymphoblastic leukemia-lymphoma

,

hematologic neoplasms

,

renal cell carcinoma

,

fallopian tube neoplasms

,

,

cutaneous malignant melanoma

,

rectal neoplasms

,

,

,

stomach neoplasms

,

esophageal neoplasms

,

,

chromosome aberrations

,

b-cell chronic lymphocytic leukemia

,

prolymphocytic leukemia

,

lymphoid leukemia

,

bcr-abl positive chronic myelogenous leukemia

,

endometrial stromal sarcoma

,

hodgkin disease

,

brain neoplasms

,

nervous system neoplasms

,

immunoglobulin light-chain amyloidosis

,

,

hepatocellular carcinoma

,

liver neoplasms

,

phenylketonurias

,

hematopoietic stem cell transplantation

,

,

t-cell lymphoma

,

t-cell lymphoma peripheral

,

,

non-hodgkin lymphoma

,

myelodysplastic syndromes

,

,

ovarian neoplasms

,

neurofibrosarcoma

,

extranodal nk-t-cell lymphoma

,

central nervous system neoplasms

,

,

,

breast neoplasms

,

non-small-cell lung carcinoma

,

triple negative breast neoplasms

,

,

,

colorectal neoplasms

,

nerve sheath neoplasms

,

,

glandular and epithelial neoplasms

,

small cell lung carcinoma

,

thrombocytopenia

,

squamous cell neoplasms

,

alveolar soft part sarcoma

,

,

pancreatic ductal carcinoma

,

prostatic neoplasms

,

,

coronavirus infections

,

,

thymus neoplasms

,

,

,

drug-related side effects and adverse reactions

,

gastrointestinal stromal tumors

,

maximum tolerated dose

,

recreational drug use

,

pancreatic neoplasms

,

acinar cell carcinoma

,

squamous cell carcinoma

,

b-cell lymphoma marginal zone

,

follicular lymphoma

,

waldenstrom macroglobulinemia

,

urologic neoplasms

,

transitional cell carcinoma

,

,

communicable diseases

,

,

,

,

t-cell lymphoma cutaneous

,

neuroendocrine carcinoma

,

uterine cervical neoplasms

,

smoldering multiple myeloma

,

residual neoplasm

,

ovarian epithelial carcinoma

,

,

,

,

clear cell sarcoma

,

,

hemangiosarcoma

,

epithelioid hemangioendothelioma

,

synovial sarcoma

,

myxoid liposarcoma

,

benign fibrous histiocytoma

,

,

disorders of sex development

,

dermatofibrosarcoma

,

adipose tissue neoplasms

,

granular cell tumor

,

myelomonocytic leukemia chronic

,

myelomonocytic leukemia juvenile

,

,

multiple myeloma

,

plasma cell neoplasms

,

myeloid leukemia acute

,

,

,

,

myeloid leukemia

,

primary myelofibrosis

,

endometrial neoplasms

,

,

,

myeloproliferative disorders

,

,

uterine neoplasms

,

neoplasms by site

,

uterine diseases

,

genital diseases

,

epstein-barr virus infections

,

hemophagocytic lymphohistiocytosis

,

,

large b-cell lymphoma diffuse

,

b-cell lymphoma

,

mantle-cell lymphoma

,

salivary gland neoplasms

,

,

myeloid sarcoma

,

colorectal neoplasms

,

non-small-cell lung carcinoma

,

triple negative breast neoplasms

,

squamous cell carcinoma of head and neck

,

multiple myeloma

,

plasma cell neoplasms

,

,

follicular lymphoma

,

,

brain neoplasms

,

,

healthy volunteers/patients

healthy volunteers/patients

,

multiple myeloma

,

b-cell chronic lymphocytic leukemia

,

plasma cell neoplasms

,

hematologic neoplasms

,

hodgkin disease

,

,

,

,

non-hodgkin lymphoma

,

mantle-cell lymphoma

,

,

,

,

,

,

,

large-cell lymphoma anaplastic

,

clear cell sarcoma

,

healthy volunteers/patients

,

neoplasms by histologic type

,

neoplasms by site

,

nervous system neoplasms

,

aids-related lymphoma

,

optic nerve glioma

,

primitive neuroectodermal tumors peripheral

,

leukemia myeloid chronic atypical bcr-abl negative

,

immunoblastic lymphadenopathy

,

hairy cell leukemia

,

,

eyelid diseases

,

basal cell carcinoma

,

merkel cell carcinoma

,

basal cell neoplasms

,

human influenza

,

brain stem neoplasms

,

cerebrotendinous xanthomatosis

,

adenocarcinoma of lung

,

,

mycobacterium avium-intracellulare infection

,

cognitive dysfunction

,

,

,

myasthenia gravis

,

conjunctival neoplasms

,

alveolar soft part sarcoma

,

salivary gland neoplasms

,

testicular neoplasms

,

medullary carcinoma

,

thrombocytopenia

,

paroxysmal hemoglobinuria

,

aids-related complex

,

,

drug-related side effects and adverse reactions

,

pharmacokinetics

,

oligodendroglioma

,

pseudomyxoma peritonei

,

colorectal neoplasms

,

ovarian neoplasms

,

b-cell chronic lymphocytic leukemia

,

mantle-cell lymphoma

,

myeloproliferative disorders

,

fallopian tube neoplasms

,

,

myelomonocytic leukemia chronic

,

,

small cell lung carcinoma

,

male breast neoplasms

,

,

kidney neoplasms

,

t-cell lymphoma peripheral

,

,

aplastic anemia

,

,

hepatocellular carcinoma

,

liver neoplasms

,

myelomonocytic leukemia juvenile

,

ovarian epithelial carcinoma

,

colonic neoplasms

,

central nervous system neoplasms

,

,

t-cell lymphoma

,

,

cutaneous malignant melanoma

,

myeloid leukemia accelerated phase

,

respiratory distress syndrome

,

communicable diseases

,

,

rectal neoplasms

,

waldenstrom macroglobulinemia

,

large-cell lymphoma immunoblastic

,

stem cell transplantation

,

refractory anemia

,

myelodysplastic-myeloproliferative diseases

,

,

alzheimer disease

,

uveal neoplasms

,

,

squamous cell carcinoma of head and neck

,

cholangiocarcinoma

,

,

rheumatoid arthritis

,

,

endometrial neoplasms

,

b-cell lymphoma marginal zone

,

interdigitating dendritic cell sarcoma

,

primary myelofibrosis

,

t-cell lymphoma cutaneous

,

,

castration-resistant prostatic neoplasms

,

peripheral arterial disease

,

ductal carcinoma breast

,

intraductal carcinoma noninfiltrating

,

plasma cell leukemia

,

,

eyelid neoplasms

,

,

nasopharyngeal carcinoma

,

,

,

immunoglobulin light-chain amyloidosis

,

diffuse intrinsic pontine glioma

,

transitional cell carcinoma

,

esophageal neoplasms

,

sezary syndrome

,

mycosis fungoides

,

kidney transplantation

,

malignant mesothelioma

,

fanconi syndrome

,

glandular and epithelial neoplasms

,

endometrioid carcinoma

,

,

,

peritoneal neoplasms

,

mycobacterium infections

,

bronchiolitis obliterans syndrome

,

severe acute respiratory syndrome

,

acute lung injury

,

newborn respiratory distress syndrome

,

,

cystic fibrosis

,

pancreatic ductal carcinoma

,

gallbladder neoplasms

,

hematopoietic stem cell transplantation

,

meningeal carcinomatosis

,

myeloid sarcoma

,

branchio-oto-renal syndrome

,

hypereosinophilic syndrome

,

inflammatory breast neoplasms

,

ganglioneuroblastoma

,

residual neoplasm

,

nasopharyngeal neoplasms

,

gastrointestinal neoplasms

,

neuroendocrine tumors

,

neuroendocrine carcinoma

,

islet cell carcinoma

,

urethral neoplasms

,

ureteral neoplasms

,

invasive hydatidiform mole

,

esophageal squamous cell carcinoma

,

sickle cell anemia

,

renal insufficiency

,

immunologic deficiency syndromes

,

,

pulmonary hypertension

,

interstitial lung diseases

,

lymphoproliferative disorders

,

extranodal nk-t-cell lymphoma

,

prolymphocytic leukemia

,

second primary neoplasms

,

,

bone marrow diseases

,

thymus neoplasms

,

biliary tract neoplasms

,

,

mucinous cystadenocarcinoma

,

serous cystadenocarcinoma

,

cystadenocarcinoma

,

neurofibrosarcoma

,

nerve sheath neoplasms

,

,

animal mammary neoplasms

,

precursor b-cell lymphoblastic leukemia-lymphoma

,

systemic lupus erythematosus

,

severe acute respiratory syndrome-related coronavirus

,

,

kidney diseases

,

urogenital neoplasms

,

prostatic diseases

,

male genital neoplasms

,

critical illness

,

immunosuppression therapy

,

,

,

nontuberculous mycobacterium infections

,

vascular diseases

,

atherosclerosis

,

respiratory aspiration

,

intermittent claudication

,

pneumococcal pneumonia

,

,

bile duct neoplasms

,

intestinal neoplasms

,

,

peripheral blood stem cell transplantation

,

,

,

meningeal neoplasms

,

soft tissue neoplasms

,

philadelphia chromosome

,

,

,

myelodysplastic syndromes

,

breast neoplasms

,

myeloid leukemia

,

plasma cell neoplasms

,

bcr-abl positive chronic myelogenous leukemia

,

hodgkin disease

,

,

large b-cell lymphoma diffuse

,

neoplasm metastasis

,

,

lymphoid leukemia

,

,

,

non-small-cell lung carcinoma

,

burkitt lymphoma

,

,

pancreatic neoplasms

,

,

,

follicular lymphoma

,

pulmonary alveolar proteinosis

,

b-cell lymphoma

,

hematologic neoplasms

,

brain neoplasms

,

,

renal cell carcinoma

,

,

graft vs host disease

,

rhabdomyosarcoma

,

triple negative breast neoplasms

,

germ cell and embryonal neoplasms

,

precursor t-cell lymphoblastic leukemia-lymphoma

,

medulloblastoma

,

acquired immunodeficiency syndrome

,

myeloid leukemia chronic-phase

,

,

refractory anemia with excess of blasts

,

congenital abnormalities

,

,

myelomonocytic leukemia acute

,

biphenotypic leukemia acute

,

monocytic leukemia acute

,

chemotherapy-induced febrile neutropenia

,

,

urinary bladder neoplasms

,

giant cell tumor of tendon sheath

,

stomach neoplasms

,

,

hematologic diseases

,

,

squamous cell carcinoma

,

pigmented villonodular synovitis

,

,

pathologic complete response

,

,

alveolar rhabdomyosarcoma

,

embryonal rhabdomyosarcoma

,

systemic scleroderma

,

diffuse scleroderma

,

,

squamous cell neoplasms

,

head and neck neoplasms

,

megakaryoblastic leukemia acute

,

erythroblastic leukemia acute

,

cytomegalovirus retinitis

,

,

,

giant cell tumors

,

uterine cervical neoplasms

,

hematopoietic stem cell mobilization

,

induction chemotherapy

,

t-cell leukemia

,

coronavirus infections

,

choriocarcinoma

,

,

endodermal sinus tumor

,

,

autoimmune diseases

,

,

,

multiple sclerosis

,

relapsing-remitting multiple sclerosis

,

cutaneous leishmaniasis

,

,

,

myeloid leukemia acute

,

,

multiple myeloma

,

,

,

precursor cell lymphoblastic leukemia-lymphoma

,

prostatic neoplasms

,

non-hodgkin lymphoma

,

,

,

,

chronic hepatitis b

,

,

,

multiple organ failure

,

wounds and injuries

,

,

,

abnormal karyotype

,

primitive neuroectodermal tumors

,

retinal neoplasms

,

neuroectodermal tumors

,

phenylketonurias

,

liver cirrhosis

,

uterine neoplasms

,

,

cytokine release syndrome

,

normal pressure hydrocephalus

,

,

diabetes mellitus

,

frontotemporal dementia

,

neuroinflammatory diseases

,

corticobasal degeneration

,

muscular atrophy

,

spinal muscular atrophy

,

,

,

periodontal diseases

,

,

,

,

Aglatimagene besadenovec

prostatic hyperplasia

,

,

erectile dysfunction

,

anxiety disorders

,

depressive disorder

,

,

,

,

,

multiple myeloma

,

plasma cell neoplasms

,

chronic hepatitis b

,

human influenza

,

chronic hepatitis

,

urinary tract infections

,

escherichia coli infections

,

restless legs syndrome

,

psychomotor agitation

,

Calcium dobesilate

colorectal neoplasms

,

head and neck neoplasms

,

squamous cell carcinoma of head and neck

,

squamous cell neoplasms

,

non-small-cell lung carcinoma

,

,

neoplasm metastasis

,

multiple myeloma

,

plasma cell neoplasms

cerebrotendinous xanthomatosis

,

aids-related complex

,

,

ovarian neoplasms

,

,

central nervous system neoplasms

,

germ cell and embryonal neoplasms

,

liver neoplasms

,

nervous system neoplasms

,

non-hodgkin lymphoma

,

,

multiple myeloma

,

,

,

plasma cell neoplasms

,

hodgkin disease

,

,

acquired immunodeficiency syndrome

,

,

myeloid leukemia acute

,

myeloid leukemia

,

,

,

,

non-small-cell lung carcinoma

,

prostatic neoplasms

,

,

urinary bladder neoplasms

,

transitional cell carcinoma

,

,

,

type 1 diabetes mellitus

,

smoldering multiple myeloma

,

myeloproliferative disorders

,

hematologic diseases

,

aplastic anemia

,

,

,

breast neoplasms

,

,

precursor cell lymphoblastic leukemia-lymphoma

,

lymphoid leukemia

,

myelodysplastic syndromes

,

,

,

,

graft vs host disease

,

b-cell lymphoma

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