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Company ReportsKaryopharm Therapeutics

Karyopharm Therapeutics(KPTI)

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Trade Name	Drug Name	Approved	Patent Expires	Indication
Xpovio	Selinexor	2019-07-03	2032-2035	Multiple myeloma

Clinical Trials

Therapeutic Areas:

All

Classification:

All

Approval:

All

Status:

All

Phases:

All

Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

neoplasm metastasis

,

biphenotypic leukemia acute

,

precursor cell lymphoblastic leukemia-lymphoma

,

hematologic neoplasms

,

lymphoid leukemia

,

renal cell carcinoma

,

fallopian tube neoplasms

,

,

cutaneous malignant melanoma

,

rectal neoplasms

,

,

,

stomach neoplasms

,

esophageal neoplasms

,

,

chromosome aberrations

,

b-cell chronic lymphocytic leukemia

,

prolymphocytic leukemia

,

bcr-abl positive chronic myelogenous leukemia

,

,

,

endometrial stromal sarcoma

,

hodgkin disease

,

brain neoplasms

,

nervous system neoplasms

,

immunoglobulin light-chain amyloidosis

,

,

hepatocellular carcinoma

,

liver neoplasms

,

phenylketonurias

,

hematopoietic stem cell transplantation

,

,

non-hodgkin lymphoma

,

t-cell lymphoma

,

t-cell lymphoma peripheral

,

myelodysplastic syndromes

,

,

,

ovarian neoplasms

,

,

,

breast neoplasms

,

non-small-cell lung carcinoma

,

triple negative breast neoplasms

,

,

,

colorectal neoplasms

,

neurofibrosarcoma

,

nerve sheath neoplasms

,

,

small cell lung carcinoma

,

central nervous system neoplasms

,

squamous cell neoplasms

,

alveolar soft part sarcoma

,

,

pancreatic ductal carcinoma

,

prostatic neoplasms

,

mantle-cell lymphoma

,

coronavirus infections

,

,

glandular and epithelial neoplasms

,

thymus neoplasms

,

,

thrombocytopenia

,

,

drug-related side effects and adverse reactions

,

gastrointestinal stromal tumors

,

maximum tolerated dose

,

recreational drug use

,

pancreatic neoplasms

,

acinar cell carcinoma

,

essential thrombocythemia

,

polycythemia vera

,

,

,

squamous cell carcinoma

,

b-cell lymphoma marginal zone

,

follicular lymphoma

,

waldenstrom macroglobulinemia

,

urologic neoplasms

,

transitional cell carcinoma

,

,

communicable diseases

,

,

,

,

t-cell lymphoma cutaneous

,

neuroendocrine carcinoma

,

uterine cervical neoplasms

,

smoldering multiple myeloma

,

residual neoplasm

,

ovarian epithelial carcinoma

,

,

,

,

hemangiosarcoma

,

benign fibrous histiocytoma

,

,

extranodal nk-t-cell lymphoma

,

ductal carcinoma

,

myelomonocytic leukemia chronic

,

myelomonocytic leukemia juvenile

,

multiple myeloma

,

plasma cell neoplasms

,

myeloid leukemia acute

,

,

,

,

myeloid leukemia

,

primary myelofibrosis

,

endometrial neoplasms

,

,

,

,

myeloproliferative disorders

,

,

large b-cell lymphoma diffuse

,

b-cell lymphoma

,

salivary gland neoplasms

,

multiple myeloma

,

plasma cell neoplasms

,

colorectal neoplasms

,

non-small-cell lung carcinoma

,

triple negative breast neoplasms

,

squamous cell carcinoma of head and neck

,

multiple myeloma

,

plasma cell neoplasms

,

,

follicular lymphoma

,

,

brain neoplasms

,

,

prostatic neoplasms

myeloid leukemia acute

,

biphenotypic leukemia acute

,

eyelid neoplasms

,

myeloid sarcoma

,

Aglatimagene besadenovec

prostatic neoplasms

,

castration-resistant prostatic neoplasms

,

breast neoplasms

,

ovarian neoplasms

,

,

,

cerebral infarction

,

non-alcoholic fatty liver disease

,

diabetes mellitus

,

anxiety disorders

,

depressive disorder

,

cardiovascular diseases

,

acquired immunodeficiency syndrome

,

ureteral neoplasms

,

cutaneous malignant melanoma

,

vitamin d deficiency

,

pharmacokinetics

,

type 1 diabetes mellitus

,

,

pneumococcal infections

,

parkinson disease

,

pelvic neoplasms

,

extranodal nk-t-cell lymphoma

,

enteropathy-associated t-cell lymphoma

,

adult t-cell leukemia-lymphoma

,

intestinal neoplasms

,

,

local anesthesia

,

liver transplantation

,

cholangiocarcinoma

,

therapeutic equivalency

,

,

voice disorders

,

,

nutritional status

,

neuromyelitis optica

,

pharmacological phenomena

,

alpha 1-antitrypsin deficiency

,

motor neuron disease

,

male infertility

,

substance-related disorders

,

cerebrovascular disorders

,

vascular diseases

,

brain infarction

,

alzheimer disease

,

bacterial infections

,

streptococcal infections

,

,

chlamydia infections

,

immunologic deficiency syndromes

,

neoplasm seeding

,

escherichia coli infections

,

cytomegalovirus infections

,

uveal neoplasms

,

,

smoking cessation

,

alveolar soft part sarcoma

,

hematopoietic stem cell transplantation

,

myeloid sarcoma

,

,

bacillary dysentery

,

,

,

waldenstrom macroglobulinemia

,

friedreich ataxia

,

discoid lupus erythematosus

,

cutaneous lupus erythematosus

,

sexual infantilism

,

,

liver cirrhosis

,

,

non-small-cell lung carcinoma

,

,

,

ovarian neoplasms

,

uterine cervical neoplasms

,

falciparum malaria

,

,

post-traumatic headache

,

triple negative breast neoplasms

,

stomach neoplasms

,

head and neck neoplasms

,

urinary bladder neoplasms

,

myelodysplastic syndromes

,

squamous cell carcinoma of head and neck

,

human influenza

,

brain neoplasms

,

urologic neoplasms

,

,

ischemic stroke

,

hematologic neoplasms

,

renal cell carcinoma

,

renal insufficiency

,

esophageal neoplasms

,

reperfusion injury

,

,

communicable diseases

,

chronic hepatitis b

,

pancreatic ductal carcinoma

,

biliary tract neoplasms

,

t-cell lymphoma

,

t-cell lymphoma peripheral

,

,

hepatocellular carcinoma

,

liver neoplasms

,

bcr-abl positive chronic myelogenous leukemia

,

myeloproliferative disorders

,

t-cell lymphoma cutaneous

,

,

congenital abnormalities

,

mantle-cell lymphoma

,

transitional cell carcinoma

,

squamous cell carcinoma

,

kidney transplantation

,

,

chronic renal insufficiency

,

acute kidney injury

,

cystic fibrosis

,

macular degeneration

,

,

,

,

ovarian epithelial carcinoma

,

invasive hydatidiform mole

,

t-cell leukemia

,

myelomonocytic leukemia chronic

,

endometrial neoplasms

,

thyroid neoplasms

,

,

,

malignant mesothelioma

,

peritoneal neoplasms

,

merkel cell carcinoma

,

central nervous system neoplasms

,

,

chronic kidney failure

,

traumatic brain injuries

,

,

delayed graft function

,

graft rejection

,

food hypersensitivity

,

,

amyotrophic lateral sclerosis

,

,

,

,

myocardial infarction

,

,

rheumatoid arthritis

,

multiple sclerosis

,

autoimmune diseases

,

systemic lupus erythematosus

,

precursor t-cell lymphoblastic leukemia-lymphoma

,

atopic dermatitis

,

myelomonocytic leukemia juvenile

,

uterine neoplasms

,

monocytic leukemia acute

,

hypereosinophilic syndrome

,

testicular neoplasms

,

,

,

medulloblastoma

,

,

,

diffuse intrinsic pontine glioma

,

essential thrombocythemia

,

polycythemia vera

,

primary myelofibrosis

,

myeloid leukemia chronic-phase

,

aplastic anemia

,

myeloid leukemia accelerated phase

,

neutrophilic leukemia chronic

,

mouth neoplasms

,

squamous cell neoplasms

,

neoplasms by histologic type

,

neoplasms by site

,

glandular and epithelial neoplasms

,

hypopharyngeal neoplasms

,

nervous system neoplasms

,

chronic fatigue syndrome

,

craniocerebral trauma

,

chinese traditional medicine

,

whiplash injuries

,

retinitis pigmentosa

,

,

,

nervous system diseases

,

,

inborn urea cycle disorders

,

,

cervical intraepithelial neoplasia

,

uterine cervical dysplasia

,

,

basal cell carcinoma

,

basal cell neoplasms

,

,

systemic scleroderma

,

juvenile arthritis

,

dermatomyositis

,

,

,

aortic valve stenosis

,

heart valve diseases

,

female genital neoplasms

,

appendiceal neoplasms

,

gastrointestinal diseases

,

neurofibrosarcoma

,

nerve sheath neoplasms

,

erectile dysfunction

,

small cell lung carcinoma

,

neuroendocrine carcinoma

,

,

respiratory tract diseases

,

male breast neoplasms

,

,

sensorineural hearing loss

,

bilateral hearing loss

,

,

,

subarachnoid hemorrhage

,

,

,

vaccine-preventable diseases

,

urinary tract infections

,

molecular targeted therapy

,

meningeal carcinomatosis

,

,

healthy volunteers/patients

,

,

colorectal neoplasms

,

neoplasm metastasis

,

pancreatic neoplasms

,

prostatic neoplasms

,

follicular lymphoma

,

,

niemann-pick diseases

,

type a niemann-pick disease

,

type c niemann-pick disease

,

pick disease of the brain

,

wounds and injuries

,

b-cell lymphoma

,

lymphoid leukemia

,

b-cell chronic lymphocytic leukemia

,

,

myeloid leukemia

,

colonic neoplasms

,

large b-cell lymphoma diffuse

,

precursor cell lymphoblastic leukemia-lymphoma

,

rhabdomyosarcoma

,

embryonal rhabdomyosarcoma

,

,

,

,

kidney neoplasms

,

alveolar rhabdomyosarcoma

,

b-cell lymphoma marginal zone

,

frontotemporal dementia

,

primary progressive aphasia

,

,

rectal neoplasms

,

,

,

,

,

,

hydatidiform mole

,

chronic hepatitis c

,

,

hypersensitivity

,

,

respiratory syncytial virus infections

,

,

gestational trophoblastic disease

,

choriocarcinoma

,

trophoblastic neoplasms

,

hodgkin disease

,

burkitt lymphoma

,

type 2 diabetes mellitus

,

chronic hepatitis

,

oropharyngeal neoplasms

,

coronavirus infections

,

,

multiple organ failure

,

hypercholesterolemia

,

,

restless legs syndrome

,

psychomotor agitation

,

,

,

nasopharyngeal carcinoma

,

,

,

,

,

,

,

,

oxidative stress

,

b-cell leukemia

,

,

innate immunity

,

beckwith-wiedemann syndrome

,

,

,

corneal opacity

,

hereditary nonpolyposis colorectal neoplasms

,

peutz-jeghers syndrome

,

dysplastic nevus syndrome

,

hereditary sensory and autonomic neuropathies

,

esophageal and gastric varices

,

,

neurologic manifestations

,

,

meningococcal meningitis

,

meningococcal infections

,

dna virus infections

,

hepadnaviridae infections

,

mucinous adenocarcinoma

,

cystadenocarcinoma

,

immune system diseases

,

nasopharyngeal neoplasms

,

,

sickle cell anemia

,

,

pulmonary blastoma

,

hereditary angioedemas

,

,

,

breast neoplasms

,

,

,

multiple myeloma

,

myeloid leukemia acute

,

,

plasma cell neoplasms

,

non-hodgkin lymphoma

,

hereditary angioedema types i and ii

,

,

,

inborn genetic diseases

,

,

,

spinal fractures

,

postoperative pain

,

chronic obstructive pulmonary disease

,

,

iron-deficiency anemia

,

iron deficiencies

,

,

hyperlipidemias

,

non-st elevated myocardial infarction

,

,

,

,

ovarian hyperstimulation syndrome

,

replacement arthroplasty knee

,

drug interactions

,

drug-related side effects and adverse reactions

,

primary immunodeficiency diseases

,

common variable immunodeficiency

,

helicobacter infections

,

obstructive lung diseases

,

angina pectoris

,

,

,

serogroup c neisseria meningitidis

,

,

hemochromatosis

,

,

deficiency diseases

,

obstetric labor complications

,

,

residual neoplasm

,

,

allergic conjunctivitis

,

,

japanese encephalitis

,

,

spinal cord injuries

,

,

,

migraine disorders

,

musculoskeletal manipulations

,

periodontal diseases

,

circulating neoplastic cells

,

,

,

,

,

,

,

headache disorders

,

panoramic radiography

,

carotid artery diseases

,

,

,

temporomandibular joint disorders

,

edentulous mouth

,

bone resorption

,

intervertebral disc degeneration

,

kidney diseases

,

wrist fractures

,

,

,

radius fractures

,

venous thrombosis

,

alveolar bone loss

,

periapical periodontitis

,

medically unexplained symptoms

,

cone-beam computed tomography

,

,

vertebral artery dissection

,

,

postmenopausal osteoporosis

,

,

transcranial magnetic stimulation

,

mandibular nerve injuries

,

autistic disorder

,

autism spectrum disorder

,

pervasive child development disorders

,

intervertebral disc displacement

,

,

magnetic resonance imaging

,

transcranial direct current stimulation

,

joint dislocations

,

,

,

ischemic postconditioning

,

,

obstructive sleep apnea

,

neoadjuvant therapy

,

metabolic syndrome

,

,

,

adenocarcinoma of lung

,

skin abnormalities

,

,

intellectual disability

,

,

,

,

chromosome aberrations

,

premature birth

,

,

temporomandibular joint dysfunction syndrome

,

dental implantation

,

,

,

,

,

psychotic disorders

,

psychotic affective disorders

,

,

mental disorders

,

feeding and eating disorders

,

personality disorders

,

fertilization in vitro

,

,

wet macular degeneration

,

microcirculation

,

,

immunologic tests

,

graft vs host disease

,

abdominal hernia

,

,

internal hernia

,

colles' fracture

,

,

myofascial pain syndromes

,

musculoskeletal diseases

,

cardiac surgical procedures

,

brain hypoxia-ischemia

,

enhanced recovery after surgery

,

,

venous insufficiency

,

,

orthostatic hypotension

,

vascular stiffness

,

renin-angiotensin system

,

,

sprains and strains

,

newborn infant diseases

,

hereditary congenital and neonatal diseases and abnormalities

,

periodontal pocket

,

dental pulp diseases

,

periodontal attachment loss

,

,

highly active antiretroviral therapy

,

,

persistent infection

,

,

arteriosclerosis

,

,

carotid stenosis

,

,

,

pelvic floor disorders

,

venous thromboembolism

,

,

pulmonary embolism

,

myotonic dystrophy

,

musculoskeletal pain

,

,

atrial fibrillation

,

dental pulp necrosis

,

root resorption

,

,

executive function

,

,

,

spinal injuries

,

edentulous jaw partially

,

,

,

,

,

,

,

major depressive disorder

,

gingival recession

,

thyroid diseases

,

parathyroid diseases

,

barrett esophagus

,

,

single-tooth dental implants

,

iga glomerulonephritis

,

atherosclerosis

,

,

,

metabolic bone diseases

,

dental implants

,

,

staphylococcus aureus

,

tension-type headache

,

soft tissue injuries

,

irritable bowel syndrome

,

inflammatory bowel diseases

,

intestinal diseases

,

ankle fractures

,

,

artificial respiration

,

arnold-chiari malformation

,

brain concussion

,

,

systemic mastocytosis

,

,

,

,

,

electroencephalography

,

drug resistant epilepsy

,

,

immunoglobulin light-chain amyloidosis

,

,

exercise therapy

,

pelvic organ prolapse

,

uterine prolapse

,

,

neuroprotection

,

,

peri-implantitis

,

,

pregnancy complications

,

fetal growth retardation

,

gestational diabetes

,

,

,

knee osteoarthritis

,

,

,

,

positron emission tomography computed tomography

,

,

,

relapsing-remitting multiple sclerosis

,

,

,

maxillary sinusitis

,

,

heart disease risk factors

,

suicidal ideation

,

,

mandibular fractures

,

brachial plexus block

,

aggressive periodontitis

,

,

dentofacial deformities

,

developmental disabilities

,

radiation effects

,

,

,

,

anatomic variation

Calcium dobesilate

,

,

immunoglobulin light-chain amyloidosis

,

smoldering multiple myeloma

,

,

large b-cell lymphoma diffuse

,

b-cell lymphoma

,

myelodysplastic syndromes

,

myelomonocytic leukemia chronic

,

,

,

multiple myeloma

,

plasma cell neoplasms

,

,

b-cell chronic lymphocytic leukemia

,

lymphoid leukemia

,

myelodysplastic syndromes

,

,

myeloproliferative disorders

,

myelodysplastic-myeloproliferative diseases

,

myeloid leukemia

,

myeloid leukemia acute

,

biphenotypic leukemia acute

,

,

eyelid neoplasms

,

myeloid sarcoma

,

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