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Company ReportsKaryopharm Therapeutics

Karyopharm Therapeutics(KPTI)

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Trade Name	Drug Name	Approved	Patent Expires	Indication
Xpovio	Selinexor	2019-07-03	2032-2035	Multiple myeloma

Clinical Trials

Therapeutic Areas:

All

Classification:

All

Approval:

All

Status:

All

Phases:

All

Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

neoplasm metastasis

,

precursor cell lymphoblastic leukemia-lymphoma

,

hematologic neoplasms

,

lymphoid leukemia

,

renal cell carcinoma

,

fallopian tube neoplasms

,

,

cutaneous malignant melanoma

,

rectal neoplasms

,

,

,

stomach neoplasms

,

esophageal neoplasms

,

,

b-cell chronic lymphocytic leukemia

,

prolymphocytic leukemia

,

biphenotypic leukemia acute

,

bcr-abl positive chronic myelogenous leukemia

,

,

,

endometrial stromal sarcoma

,

hodgkin disease

,

brain neoplasms

,

nervous system neoplasms

,

,

immunoglobulin light-chain amyloidosis

,

hepatocellular carcinoma

,

liver neoplasms

,

phenylketonurias

,

hematopoietic stem cell transplantation

,

,

,

non-hodgkin lymphoma

,

t-cell lymphoma

,

,

t-cell lymphoma peripheral

,

myelodysplastic syndromes

,

,

,

,

ovarian neoplasms

,

breast neoplasms

,

non-small-cell lung carcinoma

,

triple negative breast neoplasms

,

,

colorectal neoplasms

,

neurofibrosarcoma

,

nerve sheath neoplasms

,

,

,

small cell lung carcinoma

,

central nervous system neoplasms

,

squamous cell neoplasms

,

alveolar soft part sarcoma

,

pancreatic ductal carcinoma

,

prostatic neoplasms

,

mantle-cell lymphoma

,

,

coronavirus infections

,

,

glandular and epithelial neoplasms

,

thymus neoplasms

,

,

,

thrombocytopenia

,

,

drug-related side effects and adverse reactions

,

gastrointestinal stromal tumors

,

maximum tolerated dose

,

recreational drug use

,

pancreatic neoplasms

,

acinar cell carcinoma

,

essential thrombocythemia

,

polycythemia vera

,

,

,

squamous cell carcinoma

,

b-cell lymphoma marginal zone

,

follicular lymphoma

,

waldenstrom macroglobulinemia

,

urologic neoplasms

,

transitional cell carcinoma

,

,

communicable diseases

,

,

,

,

t-cell lymphoma cutaneous

,

neuroendocrine carcinoma

,

uterine cervical neoplasms

,

smoldering multiple myeloma

,

ovarian epithelial carcinoma

,

,

,

hemangiosarcoma

,

benign fibrous histiocytoma

,

,

extranodal nk-t-cell lymphoma

,

ductal carcinoma

,

myelomonocytic leukemia chronic

,

myelomonocytic leukemia juvenile

,

multiple myeloma

,

plasma cell neoplasms

,

myeloid leukemia acute

,

,

myeloid leukemia

,

,

,

primary myelofibrosis

,

endometrial neoplasms

,

,

,

,

,

large b-cell lymphoma diffuse

,

b-cell lymphoma

,

salivary gland neoplasms

multiple myeloma

,

plasma cell neoplasms

,

follicular lymphoma

,

large b-cell lymphoma diffuse

,

b-cell lymphoma

renal cell carcinoma

,

,

non-small-cell lung carcinoma

,

,

,

,

hodgkin disease

,

t-cell lymphoma

,

t-cell lymphoma peripheral

,

prostatic neoplasms

Aglatimagene besadenovec

prostatic neoplasms

healthy volunteers/patients

,

,

breast neoplasms

,

chemotherapy-induced febrile neutropenia

,

febrile neutropenia

,

hodgkin disease

,

transitional cell carcinoma

,

invasive hydatidiform mole

Calcium dobesilate

healthy volunteers/patients

,

,

,

cesarean section

,

castration-resistant prostatic neoplasms

,

endometrioid carcinoma

,

hairy cell leukemia

,

sickle cell anemia

,

,

sleep deprivation

,

pituitary neoplasms

,

,

pituitary diseases

,

,

oligodendroglioma

,

prediabetic state

,

malignant mesothelioma

,

,

beta-thalassemia

,

,

hemoglobinopathies

,

aortic coarctation

,

systemic mastocytosis

,

,

central serous chorioretinopathy

,

,

,

,

autonomic nervous system diseases

,

,

esophageal diseases

,

,

lacrimal apparatus diseases

,

,

neuroepithelial neoplasms

,

medulloblastoma

,

,

,

,

spinal cord neoplasms

,

large granular lymphocytic leukemia

,

choroid plexus neoplasms

,

craniopharyngioma

,

primitive neuroectodermal tumors

,

choriocarcinoma

,

,

,

endodermal sinus tumor

,

neuroectodermal tumors

,

,

phenylketonurias

,

chromophobe adenoma

,

basophil adenoma

,

acidophil adenoma

,

,

,

multiple pulmonary nodules

,

solitary pulmonary nodule

,

emergence delirium

,

,

alcohol drinking

,

retinal telangiectasis

,

retinal perforations

,

insulin resistance

,

non-alcoholic fatty liver disease

,

,

,

,

tooth extraction

,

bone transplantation

,

,

,

hematologic neoplasms

,

follicular lymphoma

,

t-cell leukemia

,

b-cell lymphoma marginal zone

,

,

,

bcr-abl positive chronic myelogenous leukemia

,

plasma cell leukemia

,

squamous cell carcinoma

,

b-cell chronic lymphocytic leukemia

,

large-cell lymphoma anaplastic

,

adult t-cell leukemia-lymphoma

,

,

,

squamous cell carcinoma of head and neck

,

germ cell and embryonal neoplasms

,

,

,

t-cell lymphoma cutaneous

,

intraocular lymphoma

,

plasmablastic lymphoma

,

large-cell lymphoma immunoblastic

,

lymphomatoid granulomatosis

,

nasopharyngeal carcinoma

,

,

radiation injuries

,

uveal neoplasms

,

,

pancreatic neoplasms

,

precursor b-cell lymphoblastic leukemia-lymphoma

,

hemophagocytic lymphohistiocytosis

,

oral lichen planus

,

,

squamous cell neoplasms

,

cholangiocarcinoma

,

,

esophageal neoplasms

,

,

sudden hearing loss

,

myeloid leukemia chronic-phase

,

vitreous hemorrhage

,

pathologic complete response

,

,

extranodal nk-t-cell lymphoma

,

sezary syndrome

,

immunoblastic lymphadenopathy

,

mycosis fungoides

,

,

nervous system neoplasms

,

laryngeal neoplasms

,

laryngeal diseases

,

b-cell leukemia

,

,

wet macular degeneration

,

,

endocrine gland neoplasms

,

,

pelvic organ prolapse

,

,

clonal hematopoiesis

,

,

colonic neoplasms

,

rectal neoplasms

,

,

cerebral toxoplasmosis

,

bone marrow transplantation

,

homologous transplantation

,

autologous transplantation

,

bullous pemphigoid

,

benign mucous membrane pemphigoid

,

bronchiolitis obliterans syndrome

,

biliary tract neoplasms

,

ductal carcinoma

,

blastic plasmacytoid dendritic cell neoplasm

,

,

,

nasopharyngeal neoplasms

,

epstein-barr virus infections

,

fuchs' endothelial dystrophy

,

hereditary corneal dystrophies

,

retinitis pigmentosa

,

,

,

hematologic diseases

,

myeloid leukemia accelerated phase

,

,

choroidal neovascularization

,

retinal neovascularization

,

pathologic neovascularization

,

,

gouty arthritis

,

testicular neoplasms

,

airway obstruction

,

,

,

,

congenital abnormalities

,

small cell carcinoma

,

,

,

,

esophageal squamous cell carcinoma

,

interstitial lung diseases

,

respiratory signs and symptoms

,

intratympanic injection

,

,

parkinsonian disorders

,

,

carbon monoxide poisoning

,

,

,

,

immunoglobulin light-chain amyloidosis

,

precursor t-cell lymphoblastic leukemia-lymphoma

,

mantle-cell lymphoma

,

waldenstrom macroglobulinemia

,

,

myeloid leukemia

,

smoldering multiple myeloma

,

philadelphia chromosome

,

hodgkin disease

,

hypersensitivity

,

brain neoplasms

,

myelodysplastic syndromes

,

,

myeloid leukemia acute

,

,

,

,

ovarian neoplasms

,

central nervous system neoplasms

,

biphenotypic leukemia acute

,

neoplasm metastasis

,

,

,

,

ataxia telangiectasia

,

,

,

,

ovarian epithelial carcinoma

,

,

oropharyngeal neoplasms

,

coronavirus infections

,

severe acute respiratory syndrome

,

myelomonocytic leukemia chronic

,

myelomonocytic leukemia acute

,

myelomonocytic leukemia juvenile

,

,

,

,

adrenocortical hyperfunction

,

,

inborn genetic diseases

,

bronchopulmonary dysplasia

,

,

,

laparoscopic cholecystectomy

,

fallopian tube neoplasms

,

,

rotator cuff injuries

,

human influenza

,

viral pneumonia

,

cerebellar ataxia

,

small cell lung carcinoma

,

,

,

nervous system diseases

,

,

congenital adrenal hyperplasia

,

adrenogenital syndrome

,

,

,

thrombocytopenic purpura

,

,

liver neoplasms

,

,

,

,

,

,

,

ovarian hyperstimulation syndrome

,

uterine hemorrhage

,

promyelocytic leukemia acute

,

respiratory tract infections

,

,

communicable diseases

,

kidney diseases

,

,

traumatic brain injuries

,

,

unknown primary neoplasms

,

,

substance-related disorders

,

,

urinary bladder neoplasms

,

transitional cell carcinoma

,

ureteral neoplasms

,

,

hyperbilirubinemia

,

,

conduction anesthesia

,

forearm injuries

,

,

replacement arthroplasty hip

,

male genital neoplasms

,

,

,

,

ocular motility disorders

,

,

opsoclonus-myoclonus syndrome

,

,

,

bone marrow diseases

,

viral conjunctivitis

,

acquired immunodeficiency syndrome

,

immune reconstitution inflammatory syndrome

,

atopic dermatitis

,

allergic rhinitis

,

allergic rhinitis perennial

,

,

,

megakaryoblastic leukemia acute

,

monocytic leukemia acute

,

refractory anemia with excess of blasts

,

erythroblastic leukemia acute

,

refractory anemia

,

digestive system surgical procedures

,

breast carcinoma in situ

,

,

,

,

hepatocellular carcinoma

,

spinal dysraphism

,

acanthamoeba keratitis

,

,

agranulocytosis

,

feeding behavior

,

multiple myeloma

,

plasma cell neoplasms

,

,

precursor cell lymphoblastic leukemia-lymphoma

,

,

lymphoid leukemia

,

,

,

,

,

postoperative pain

,

,

postoperative nausea and vomiting

,

non-hodgkin lymphoma

,

,

,

retinal vein occlusion

,

,

b-cell lymphoma

,

,

,

,

retinal diseases

,

breast neoplasms

,

large b-cell lymphoma diffuse

,

diabetic retinopathy

,

dry eye syndromes

,

,

replacement arthroplasty knee

,

,

prostatic neoplasms

,

thrombocytopenic purpura idiopathic

,

diabetes mellitus

,

t-cell lymphoma

,

thrombocytopenia

,

non-small-cell lung carcinoma

,

keratoconjunctivitis sicca

,

respiratory distress syndrome

,

,

t-cell lymphoma peripheral

,

epiretinal membrane

,

,

burkitt lymphoma

,

,

local anesthesia

,

,

,

newborn respiratory distress syndrome

,

renal insufficiency

,

capsule opacification

,

vision disorders

,

brachial plexus block

,

,

,

,

,

premature birth

,

,

macular degeneration

,

,

anesthesia and analgesia

,

migraine disorders

,

knee osteoarthritis

,

allergic conjunctivitis

,

cataract extraction

,

,

,

retinal detachment

,

sensorineural hearing loss

,

acute lung injury

,

posterior uveitis

,

,

,

,

anterior cruciate ligament injuries

,

shoulder injuries

,

,

,

,

,

anterior uveitis

,

,

postoperative complications

,

,

,

,

drug-related side effects and adverse reactions

,

,

residual neoplasm

,

,

,

pain management

,

,

spinal anesthesia

,

respiratory insufficiency

,

intravenous substance abuse

,

patient preference

,

intervertebral disc displacement

,

,

pathologic constriction

,

spinal stenosis

,

,

dissociative disorders

,

,

head and neck neoplasms

,

,

obstructive sleep apnea

,

peripheral arterial disease

,

peripheral vascular diseases

,

trigger finger disorder

,

intermediate uveitis

,

,

type 2 diabetes mellitus

,

carpal tunnel syndrome

,

,

wounds and injuries

,

gastrointestinal neoplasms

,

chronic kidney failure

,

,

colorectal neoplasms

,

,

hip osteoarthritis

,

anterior cruciate ligament reconstruction

,

shoulder impingement syndrome

,

graft vs host disease

,

,

penetrating keratoplasty

,

,

vitreoretinal surgery

,

,

,

,

refractive surgical procedures

,

,

femoral fractures

,

,

endophthalmitis

,

subdural hematoma

,

,

subdural hematoma chronic

,

postoperative cognitive complications

,

cognitive dysfunction

,

,

,

descemet stripping endothelial keratoplasty

,

femoral neck fractures

,

,

,

,

,

,

radius fractures

,

wrist fractures

,

,

,

,

spinal diseases

,

,

opioid-related disorders

,

urethral stricture

,

gastrointestinal diseases

,

inflammatory bowel diseases

,

digestive system diseases

,

intestinal diseases

,

ambulatory surgical procedures

,

nasal surgical procedures

,

general anesthesia

,

ankle fractures

,

,

pharmacokinetics

,

meibomian gland dysfunction

,

treatment outcome

,

,

,

corneal transplantation

,

intraocular pressure

,

vitamin d deficiency

,

,

hypoparathyroidism

,

viral bronchiolitis

,

temporomandibular joint disorders

,

temporomandibular joint dysfunction syndrome

,

systemic inflammatory response syndrome

,

,

orthopedic procedures

,

sleep apnea syndromes

,

corneal endothelial cell loss

,

,

,

,

,

status asthmaticus

,

meningeal tuberculosis

,

,

dental deposits

,

,

,

,

sjogren's syndrome

,

,

patient-controlled analgesia

,

,

chronic renal insufficiency

,

,

diabetic angiopathies

,

,

foot deformities

,

congenital foot deformities

,

walker-warburg syndrome

,

,

,

dupuytren contracture

,

,

fracture fixation

,

elbow tendinopathy

,

peripheral nervous system diseases

,

deglutition disorders

,

respiratory sounds

,

,

,

,

,

thyroid diseases

,

vascular diseases

,

,

digestive system neoplasms

,

,

mucinous cystadenocarcinoma

,

serous cystadenocarcinoma

,

peritoneal neoplasms

,

cystadenocarcinoma

,

myeloproliferative disorders

,

myelodysplastic-myeloproliferative diseases

,

trophoblastic neoplasms

,

ventilator-associated pneumonia

,

abnormal karyotype

,

post-dural puncture headache

,

ureterolithiasis

,

rheumatoid arthritis

,

nerve compression syndromes

,

hypertrophic cicatrix

,

,

,

,

,

,

patient reported outcome measures

,

patient satisfaction

,

,

intractable pain

,

pituitary acth hypersecretion

,

acth-secreting pituitary adenoma

,

ocular hypertension

,

optic nerve diseases

,

cognition disorders

,

,

postherpetic neuralgia

,

,

hyaline membrane disease

,

,

,

,

trigeminal neuralgia

,

dentin sensitivity

,

,

,

,

,

,

thoracic surgical procedures

,

,

,

,

,

,

transient tachypnea of the newborn

,

,

,

thyroid neoplasms

,

vocal cord paralysis

,

female genital diseases

,

glucose intolerance

,

postoperative hemorrhage

,

surgical blood loss

,

,

perioperative period

,

parathyroid diseases

,

,

male breast neoplasms

,

,

biological availability

,

pruritus vulvae

,

meniere disease

,

vestibular diseases

,

intranasal administration

,

meconium aspiration syndrome

,

,

dental pulp necrosis

,

therapeutic equivalency

,

knee prosthesis

,

,

,

oxidative stress

,

antibiotic prophylaxis

,

intravenous administration

,

urinary retention

,

human influenza

ventilator-associated pneumonia

,

,

myeloid leukemia

,

,

myelodysplastic syndromes

,

myeloid leukemia acute

,

,

prostatic neoplasms

,

castration-resistant prostatic neoplasms

,

colorectal neoplasms

,

multiple myeloma

,

plasma cell neoplasms

healthy volunteers/patients

,

,

hepatic insufficiency

,

multiple myeloma

,

plasma cell neoplasms

healthy volunteers/patients

,

,

myeloid leukemia acute

,

myeloid leukemia

1

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