ELTANEXOR
Eltanexor is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target exportin-1.
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2Y
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Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
No data
Clinical
Clinical Trials
3 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myelodysplastic syndromes | D009190 | — | D46 | 3 | 2 | — | — | — | 3 |
| Preleukemia | D011289 | — | — | 3 | 2 | — | — | — | 3 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 2 | 1 | — | — | — | 2 |
| Syndrome | D013577 | — | — | 2 | 1 | — | — | — | 2 |
| Prostatic neoplasms | D011471 | — | C61 | 1 | 1 | — | — | — | 1 |
| Castration-resistant prostatic neoplasms | D064129 | — | — | 1 | 1 | — | — | — | 1 |
| Colorectal neoplasms | D015179 | — | — | 1 | 1 | — | — | — | 1 |
| Multiple myeloma | D009101 | — | C90.0 | 1 | 1 | — | — | — | 1 |
| Plasma cell neoplasms | D054219 | — | — | 1 | 1 | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | ELTANEXOR |
| INN | eltanexor |
| Description | Eltanexor is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target exportin-1. |
| Classification | Small molecule |
| Drug class | exportin 1 inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NC(=O)/C(=C/n1cnc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1)c1cncnc1 |
Identifiers
| PDB | — |
| CAS-ID | 1642300-52-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297623 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB16153 |
| UNII ID | Q59IQJ9NTK (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
XPO1
XPO1
Organism
Homo sapiens
Gene name
XPO1
Gene synonyms
CRM1
NCBI Gene ID
Protein name
exportin-1
Protein synonyms
chromosome region maintenance 1 homolog, Chromosome region maintenance 1 protein homolog, exportin 1 (CRM1 homolog, yeast), exportin-1 (required for chromosome region maintenance)
Uniprot ID
Mouse ortholog
Xpo1 (103573)
exportin-1 (Q6P5F9)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 109 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
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