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Trade Name	Drug Name	Approved	Patent Expires	Indication
Bonjesta	Doxylamine, Pyridoxine	2016-11-07	2033	Headache , Sleep initiation and maintenance disorders , Allergic rhinitis perennial , Seizures , Vitamin b 6 deficiency
Diclegis	Doxylamine, Pyridoxine	2013-04-08	2033	Headache , Sleep initiation and maintenance disorders , Allergic rhinitis perennial , Seizures , Vitamin b 6 deficiency
Osphena	Ospemifene	2013-02-26	2024-2028	Dyspareunia , Atrophy , Postmenopause , Menopause

Clinical Trials

Therapeutic Areas:

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Classification:

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Approval:

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Status:

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Phases:

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Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

cognitive dysfunction

,

,

,

biological availability

,

,

triple negative breast neoplasms

,

,

myeloproliferative disorders

,

bcr-abl positive chronic myelogenous leukemia

,

myelodysplastic-myeloproliferative diseases

,

neoplasm metastasis

,

,

,

prostatic intraepithelial neoplasia

,

,

hyperlipidemias

,

,

sedentary behavior

,

,

,

,

type 1 diabetes mellitus

,

autistic disorder

,

autism spectrum disorder

,

,

,

,

,

,

chronic fatigue syndrome

,

,

traumatic brain injuries

,

chronic obstructive pulmonary disease

,

,

,

non-small-cell lung carcinoma

,

,

anxiety disorders

,

,

obstructive lung diseases

,

,

encephalomyelitis

,

,

gastrointestinal diseases

,

,

physical fitness

,

respiratory distress syndrome

,

newborn respiratory distress syndrome

,

metabolic syndrome

,

,

hemoglobinopathies

,

wounds and injuries

,

cystic fibrosis

,

carcinoma in situ

,

,

venous insufficiency

,

,

peripheral arterial disease

,

arteriosclerosis

,

,

alveolar soft part sarcoma

,

multiple myeloma

,

plasma cell neoplasms

,

,

large b-cell lymphoma diffuse

,

b-cell lymphoma

,

nodding syndrome

,

muscle weakness

,

human influenza

,

,

acute lung injury

,

pulmonary alveolar proteinosis

,

temporomandibular joint disorders

,

temporomandibular joint dysfunction syndrome

,

alcohol-induced disorders

,

alcoholic fatty liver

,

squamous intraepithelial lesions

,

myocardial revascularization

,

vascular stiffness

,

fragile x syndrome

,

,

,

hemorrhagic shock

,

hyperphosphatemia

,

myofascial pain syndromes

,

hematologic diseases

,

beta-thalassemia

,

,

,

peripheral vascular diseases

,

primary ovarian insufficiency

,

,

infectious arthritis

,

bipolar disorder

,

meningoencephalitis

,

central nervous system tuberculosis

,

digestive system diseases

,

,

healthy volunteers/patients

,

breast neoplasms

,

pulmonary tuberculosis

,

,

,

acquired immunodeficiency syndrome

,

,

colorectal neoplasms

,

myocardial ischemia

,

hand-foot syndrome

,

,

,

prostatic neoplasms

,

non-alcoholic fatty liver disease

,

oxidative stress

,

,

,

memory disorders

,

coronary artery disease

,

,

pregnancy complications

,

,

,

liver cirrhosis

,

,

,

attention deficit disorder with hyperactivity

,

immunologic deficiency syndromes

,

coronary disease

,

,

bariatric surgery

,

,

infantile spasms

,

irritable bowel syndrome

,

vitamin b 6 deficiency

,

perinatal death

,

infant mortality

,

psychotic disorders

,

tardive dyskinesia

,

,

squamous cell carcinoma

,

squamous cell carcinoma of head and neck

,

reperfusion injury

,

rectal neoplasms

,

alopecia areata

,

,

drug-related side effects and adverse reactions

,

meningeal tuberculosis

,

,

chronic limb-threatening ischemia

,

,

,

myelodysplastic syndromes

,

myeloid leukemia acute

,

myeloid leukemia

,

,

,

,

,

precursor cell lymphoblastic leukemia-lymphoma

,

lymphoid leukemia

,

perinatal mortality

,

kidney transplantation

,

mycobacterium tuberculosis

,

,

,

liver neoplasms

,

substance-related disorders

,

,

,

primary hyperoxaluria

,

coronary artery bypass

,

colonic neoplasms

,

post-acute covid-19 syndrome

,

polyneuropathies

,

amyotrophic lateral sclerosis

,

motor neuron disease

,

,

,

habitual abortion

,

cluster headache

,

refractory anemia with excess of blasts

,

refractory anemia

,

multidrug-resistant tuberculosis

,

ovarian neoplasms

,

endometrial neoplasms

,

fallopian tube neoplasms

,

premature ejaculation

,

movement disorders

,

neurotoxicity syndromes

,

,

adolescent development

,

,

aphthous stomatitis

,

,

disease progression

,

mental disorders

,

hiv seropositivity

,

pregnancy outcome

,

chronic renal insufficiency

,

renal insufficiency

,

cerebral infarction

,

hematologic neoplasms

,

premature rupture fetal membranes

,

,

hepatocellular carcinoma

,

,

,

,

,

drug resistant epilepsy

,

,

,

mental competency

,

,

retinitis pigmentosa

,

,

,

child nutrition disorders

,

severe acute malnutrition

,

,

,

,

,

,

,

iron deficiencies

,

diabetes mellitus

,

iron-deficiency anemia

,

,

,

,

vitamin d deficiency

,

,

,

cardiovascular diseases

,

,

,

,

,

type 2 diabetes mellitus

,

peripheral nervous system diseases

,

communicable diseases

,

,

,

premature birth

,

hyperhomocysteinemia

,

,

myocardial infarction

,

,

,

,

latent tuberculosis

,

kidney diseases

,

alzheimer disease

,

,

,

diabetic neuropathies

,

fetal growth retardation

,

atherosclerosis

,

macular degeneration

,

,

,

,

,

depressive disorder

,

,

chronic kidney failure

,

,

systemic lupus erythematosus

,

,

polycystic ovary syndrome

,

male infertility

,

,

,

insulin resistance

,

,

,

,

morning sickness

,

major depressive disorder

,

urinary bladder neoplasms

,

dietary supplements

,

spontaneous abortion

,

pediatric obesity

,

,

hyperemesis gravidarum

,

,

,

retinal diseases

,

male breast neoplasms

,

alcoholic hepatitis

,

,

,

postoperative pain

,

problem behavior

,

prediabetic state

,

,

hyperinsulinism

,

hyperparathyroidism

,

primary hyperparathyroidism

,

end stage liver disease

,

,

,

hepatic insufficiency

,

acute-on-chronic liver failure

,

cardio-renal syndrome

,

nutrition disorders

,

fetal nutrition disorders

,

neurodevelopmental disorders

,

,

,

infant nutrition disorders

,

pernicious anemia

,

megaloblastic anemia

,

,

congenital hypothyroidism

,

diabetic retinopathy

,

,

hirschsprung disease

,

,

invasive hydatidiform mole

,

,

,

,

,

psychological sexual dysfunctions

,

,

cutaneous tuberculosis

,

,

lupus nephritis

,

,

,

glucose intolerance

,

st elevation myocardial infarction

,

deficiency diseases

,

,

growth disorders

,

,

premenstrual syndrome

,

,

,

,

parkinson disease

,

,

hypercholesterolemia

,

,

,

,

female infertility

,

migraine disorders

,

heart disease risk factors

,

endocrine system diseases

,

impulsive behavior

,

,

child development

,

psychological stress

,

nutritional status

,

folic acid deficiency

,

mitochondrial diseases

,

,

health behavior

,

respiratory tract infections

,

,

transient ischemic attack

,

,

gastrointestinal microbiome

,

,

,

bronchopulmonary dysplasia

,

,

,

tourette syndrome

,

,

pelvic infection

,

pelvic inflammatory disease

,

,

,

,

acanthosis nigricans

,

,

,

local anesthesia

,

knee osteoarthritis

,

hip osteoarthritis

,

,

biomedical enhancement

,

sleep initiation and maintenance disorders

,

respiratory sounds

,

,

,

sleep deprivation

,

allergic rhinitis

,

,

,

gestational diabetes

,

stomatognathic diseases

,

autoimmune diseases

,

neurocognitive disorders

,

medication adherence

,

breast milk expression

,

chromosome disorders

,

chromosome deletion

,

sleep wake disorders

,

failure to thrive

,

infant nutritional physiological phenomena

,

head and neck neoplasms

,

metabolic diseases

,

vitamin b 12 deficiency

,

,

protein-energy malnutrition

,

congenital heart defects

,

hospitalization

,

,

,

cardiomyopathies

,

bacterial infections

,

neural tube defects

,

spinal dysraphism

,

venous thrombosis

,

pulmonary embolism

,

,

inferior wall myocardial infarction

,

critical illness

,

hereditary breast and ovarian cancer syndrome

,

,

body weight changes

,

,

phenylketonurias

,

deprescriptions

,

uterine hemorrhage

,

,

,

hashimoto disease

,

,

,

thrombocytopenia

,

,

,

,

pervasive child development disorders

,

,

,

wet macular degeneration

,

sleep-wake transition disorders

,

wasting syndrome

,

,

hiv wasting syndrome

,

diabetic nephropathies

,

language development disorders

,

,

developmental disabilities

,

respiratory tract diseases

,

newborn infant diseases

,

premature infant diseases

,

parenteral nutrition

,

pathologic processes

,

,

,

,

fetal alcohol spectrum disorders

,

genetic variation

,

intellectual disability

,

pituitary dwarfism

,

hypervitaminosis a

,

thyroid diseases

,

,

vitamin a deficiency

,

night blindness

,

,

,

body temperature

,

teratozoospermia

,

asthenozoospermia

,

,

,

,

post-traumatic stress disorders

,

,

,

,

,

risk reduction behavior

,

,

,

,

,

high-risk pregnancy

,

replacement arthroplasty knee

,

musculoskeletal diseases

,

respiratory insufficiency

,

,

pulmonary atelectasis

,

hyaline membrane disease

,

thyroid neoplasms

,

,

immune system diseases

,

lactation disorders

,

premenstrual dysphoric disorder

,

muscle spasticity

,

,

,

social adjustment

,

psychosocial functioning

,

exercise tolerance

,

adrenocortical hyperfunction

,

,

,

essential hypertension

,

nasopharyngitis

,

eye abnormalities

,

persistent infection

,

staphylococcal infections

,

staphylococcus aureus

,

professional burnout

,

psychological burnout

,

acute kidney injury

,

,

,

assisted reproductive techniques

,

hypophosphatasia

,

,

,

,

postpartum hemorrhage

,

,

asphyxia neonatorum

,

gastrointestinal neoplasms

,

,

cesarean section

,

,

inflammatory bowel diseases

,

intestinal diseases

,

postpartum depression

,

dry eye syndromes

,

,

ulcerative colitis

,

,

bacterial vaginosis

,

vaginal diseases

,

,

,

allergic conjunctivitis

,

,

allergic rhinitis

,

allergic rhinitis seasonal

,

allergic rhinitis perennial

,

vasomotor rhinitis

hypercholesterolemia

,

hyperlipidemias

,

vitamin d deficiency

,

familial combined hyperlipidemia

,

hyperlipoproteinemias

,

,

postmenopausal osteoporosis

precursor cell lymphoblastic leukemia-lymphoma

,

,

,

lymphoid leukemia

,

,

respiratory insufficiency

,

,

giant cell arteritis

,

polymyalgia rheumatica

,

lupus nephritis

,

,

multiple myeloma

,

plasma cell neoplasms

,

,

,

,

,

pulmonary sarcoidosis

,

b-cell chronic lymphocytic leukemia

,

,

healthy volunteers/patients

,

,

hematopoietic stem cell transplantation

,

bronchiolitis obliterans syndrome

,

obstructive lung diseases

,

,

graft rejection

,

thrombocytopenic purpura idiopathic

,

thrombocytopenia

,

,

interstitial lung diseases

,

thrombocytopenic purpura

,

,

nephrotic syndrome

,

,

,

,

follicular lymphoma

,

kidney transplantation

,

,

chronic obstructive pulmonary disease

,

liver transplantation

,

graft vs host disease

,

atopic dermatitis

,

,

,

chronic kidney failure

,

,

cytomegalovirus infections

,

communicable diseases

,

kidney diseases

,

,

renal insufficiency

,

heart transplantation

,

multiple sclerosis

,

,

chronic renal insufficiency

,

,

renal replacement therapy

,

drug-related side effects and adverse reactions

,

,

relapsing-remitting multiple sclerosis

,

vascular diseases

,

,

cystic fibrosis

,

allergic bronchopulmonary aspergillosis

,

pulmonary aspergillosis

,

transplantation

,

,

end stage liver disease

,

,

disease progression

,

,

,

pregnancy complications

,

hyperemesis gravidarum

,

,

,

,

,

hyperemesis gravidarum

,

morning sickness

,

type 2 diabetes mellitus

,

diabetes mellitus

,

metabolic syndrome

,

tardive dyskinesia

,

,

myocardial revascularization

,

,

myocardial ischemia

,

coronary artery bypass

,

reperfusion injury

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