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Day One Biopharmaceuticals
Day One Biopharmaceuticals
(DAWN)
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Clinical Trials
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Drug Name
Phase 1
Phase 2
Phase 3
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Indication
Tovorafenib
neoplasms
,
melanoma
,
leukemia
,
myelodysplastic syndromes
,
myeloid leukemia acute
,
precursor cell lymphoblastic leukemia-lymphoma
,
bcr-abl positive chronic myelogenous leukemia
,
myeloid leukemia
,
multiple myeloma
,
biphenotypic leukemia acute
,
preleukemia
,
syndrome
,
anemia
,
myeloid leukemia chronic-phase
,
refractory anemia
,
plasma cell neoplasms
,
lymphoid leukemia
,
hematologic neoplasms
,
myeloid leukemia accelerated phase
,
refractory anemia with excess of blasts
,
non-hodgkin lymphoma
,
primary myelofibrosis
,
lymphoma
,
b-cell chronic lymphocytic leukemia
,
b-cell lymphoma marginal zone
,
prolymphocytic leukemia
,
follicular lymphoma
,
mantle-cell lymphoma
,
waldenstrom macroglobulinemia
,
burkitt lymphoma
,
alcoholism
,
carcinoma
,
colorectal neoplasms
,
pancreatic neoplasms
,
non-small-cell lung carcinoma
,
urinary bladder neoplasms
,
adenocarcinoma
,
papillary thyroid cancer
,
astrocytoma
,
acinar cell carcinoma
,
mutation rate
,
craniopharyngioma
,
adamantinoma
,
histiocytosis
,
langerhans-cell histiocytosis
,
glioma
PIMASERTIB
hepatocellular carcinoma
,
liver neoplasms
,
neoplasms
,
melanoma
,
non-small-cell lung carcinoma
,
colorectal neoplasms
,
hematologic neoplasms
,
carcinoma
,
breast neoplasms
,
skin neoplasms
,
neoplasm metastasis
,
cutaneous malignant melanoma
,
pancreatic neoplasms
,
adenocarcinoma
,
triple negative breast neoplasms
,
lung neoplasms
,
ovarian neoplasms
,
ovarian epithelial carcinoma
,
leukemia
,
myeloid leukemia acute
,
myeloid leukemia
,
urinary bladder neoplasms
,
papillary thyroid cancer
,
astrocytoma
,
acinar cell carcinoma
,
mutation rate
MLN-2480
neoplasms
,
melanoma
,
glioma
,
histiocytosis
,
langerhans-cell histiocytosis
Arm1
glaucoma
,
pharmacokinetics
,
acute pain
,
asthma
,
ocular hypertension
,
open-angle glaucoma
,
multiple myeloma
,
plasma cell neoplasms
,
healthy volunteers/patients
,
erectile dysfunction
,
death
,
neoplasm metastasis
,
hiv-2
,
neoplasms
,
breast neoplasms
,
prostatic neoplasms
,
lymphoma
,
pancreatic neoplasms
,
castration-resistant prostatic neoplasms
,
triple negative breast neoplasms
,
hypogonadism
,
sarcoma
,
colorectal neoplasms
,
stomach neoplasms
,
glioblastoma
,
biliary tract neoplasms
,
hypertension
,
b-cell lymphoma
,
endometrial neoplasms
,
hepatocellular carcinoma
,
esophageal neoplasms
,
liver neoplasms
,
small cell lung carcinoma
,
disease progression
,
chronic hepatitis
,
liver diseases
,
gastrointestinal diseases
,
virus diseases
,
rna virus infections
,
digestive system diseases
,
viral hepatitis human
,
flaviviridae infections
,
general anesthesia
,
chronic obstructive pulmonary disease
,
lung diseases
,
obstructive lung diseases
,
obstructive sleep apnea
,
sleep apnea syndromes
,
apnea
,
syndrome
,
disorders of excessive somnolence
,
sleepiness
,
papillomavirus infections
,
uterine cervical neoplasms
,
vaginal neoplasms
,
vulvar neoplasms
,
condylomata acuminata
,
hodgkin disease
,
migraine disorders
,
atherosclerosis
,
pancreatic ductal carcinoma
,
uterine neoplasms
,
carcinosarcoma
,
mullerian mixed tumor
,
adenocarcinoma
,
esophageal squamous cell carcinoma
,
large b-cell lymphoma diffuse
,
neuroendocrine tumors
,
intestinal neoplasms
,
head and neck neoplasms
,
prostatic hyperplasia
,
sarcopenia
,
muscular atrophy
,
eunuchism
,
hypertrophy
,
urologic neoplasms
,
transitional cell carcinoma
,
urinary bladder neoplasms
,
microsatellite instability
,
non-small-cell lung carcinoma
,
chronic hepatitis c
,
lung neoplasms
,
type 2 diabetes mellitus
,
diabetes mellitus
,
carcinoma
,
obesity
,
squamous cell carcinoma of head and neck
,
squamous cell carcinoma
,
vomiting
,
nausea
,
melanoma
,
urinary tract infections
,
anesthesia
,
keratoconjunctivitis sicca
,
dry eye syndromes
,
eye diseases
,
overweight
,
polycystic kidney diseases
,
inflammation
,
spondylarthritis
,
spondylitis
,
axial spondyloarthritis
,
neuralgia
,
postherpetic neuralgia
,
hepatitis
,
hepatitis a
,
hepatitis c
,
hiv infections
,
infections
,
communicable diseases
,
ovarian neoplasms
,
hiv
,
acquired immunodeficiency syndrome
,
ovarian epithelial carcinoma
,
herpes zoster
,
mumps
,
measles
,
chickenpox
,
rubella
,
kidney diseases
,
rheumatoid arthritis
,
arthritis
,
hepatitis a virus
,
immunosuppression therapy
,
hemorrhage
,
chronic renal insufficiency
,
chronic disease
,
drug-related side effects and adverse reactions
,
non-hodgkin lymphoma
,
follicular lymphoma
Arm2
prostatic hyperplasia
,
hyperplasia
,
anxiety disorders
,
hypertension
,
pulmonary hypertension
,
pulmonary arterial hypertension
,
hiv infections
,
erectile dysfunction
,
wounds and injuries
,
spinal cord injuries
,
spinal injuries
,
type 2 diabetes mellitus
,
diabetes mellitus
MLN2480
neoplasms
,
melanoma
,
glioma
,
histiocytosis
,
langerhans-cell histiocytosis
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