Zotepine
Zotepine is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target 5-hydroxytryptamine receptor 7, 5-hydroxytryptamine receptor 2C, 5-hydroxytryptamine receptor 6, histamine H1 receptor, D(4) dopamine receptor, D(2) dopamine receptor, sodium-dependent serotonin transporter, 5-hydroxytryptamine receptor 1B, 5-hydroxytryptamine receptor 1D, D(3) dopamine receptor, alpha-2B adrenergic receptor, sodium-dependent noradrenaline transporter, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 1A, and 5-hydroxytryptamine receptor 1E.
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3 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Delirium | D003693 | — | R41.0 | — | — | — | 1 | — | 1 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | — | — | 1 | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Zotepine |
| INN | zotepine |
| Description | Zotepine is a dibenzothiepine and a tertiary amino compound. It has a role as an alpha-adrenergic drug, a serotonergic drug and a second generation antipsychotic. |
| Classification | Small molecule |
| Drug class | tricyclic compounds |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN(C)CCOC1=Cc2ccccc2Sc2ccc(Cl)cc21 |
Identifiers
| PDB | — |
| CAS-ID | 26615-21-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL285802 |
| ChEBI ID | 32316 |
| PubChem CID | 5736 |
| DrugBank | DB09225 |
| UNII ID | U29O83JAZW (ChemIDplus, GSRS) |
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304 adverse events reported
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