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Drug ReportsZotepine
Zotepine
Zotepine is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target 5-hydroxytryptamine receptor 7, 5-hydroxytryptamine receptor 2C, 5-hydroxytryptamine receptor 6, histamine H1 receptor, D(4) dopamine receptor, D(2) dopamine receptor, sodium-dependent serotonin transporter, 5-hydroxytryptamine receptor 1B, 5-hydroxytryptamine receptor 1D, D(3) dopamine receptor, alpha-2B adrenergic receptor, sodium-dependent noradrenaline transporter, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 1A, and 5-hydroxytryptamine receptor 1E.
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ATC Codes
N: Nervous system drugs
— N05: Psycholeptics
— N05A: Antipsychotics
— N05AX: Other antipsychotics in atc
— N05AX11: Zotepine
HCPCS
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Clinical
Clinical Trials
3 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
DeliriumD003693—R41.0———1—1
SchizophreniaD012559EFO_0000692F20———1—1
Indications Phases 3
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Ontology
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Bipolar disorderD001714EFO_0000289F30.9————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameZotepine
INNzotepine
Description
Zotepine is a dibenzothiepine and a tertiary amino compound. It has a role as an alpha-adrenergic drug, a serotonergic drug and a second generation antipsychotic.
Classification
Small molecule
Drug classtricyclic compounds
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CN(C)CCOC1=Cc2ccccc2Sc2ccc(Cl)cc21
Identifiers
PDB—
CAS-ID26615-21-4
RxCUI—
ChEMBL IDCHEMBL285802
ChEBI ID32316
PubChem CID5736
DrugBankDB09225
UNII IDU29O83JAZW (ChemIDplus, GSRS)
Target
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Trends
PubMed Central
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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304 adverse events reported
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