Zopiclone
Zopiclone is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Clinical Trials
103 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sleep initiation and maintenance disorders | D007319 | — | F51.01 | 7 | 3 | 17 | 20 | 13 | 58 |
| Obstructive sleep apnea | D020181 | EFO_0003918 | G47.33 | 2 | 7 | 1 | 3 | 2 | 14 |
| Sleep apnea syndromes | D012891 | EFO_0003877 | G47.3 | 1 | 6 | 1 | 4 | 2 | 14 |
| Healthy volunteers/patients | — | — | — | 8 | — | 1 | 1 | 1 | 11 |
| Depression | D003863 | — | F33.9 | 1 | — | 3 | 3 | — | 7 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | 1 | — | 2 | 4 | — | 7 |
| Apnea | D001049 | — | R06.81 | 1 | 3 | — | 2 | 1 | 7 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | — | 1 | 1 | 3 | — | 5 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | 1 | — | 2 | 2 | — | 5 |
| Sleep wake disorders | D012893 | — | G47 | — | 1 | — | 1 | 3 | 5 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | — | 1 | — | 3 | 4 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | 1 | — | 1 | — | — | 2 |
| Hyperkinesis | D006948 | — | — | — | — | 2 | — | — | 2 |
| Attention deficit disorder with hyperactivity | D001289 | EFO_0003888 | F90 | — | — | 2 | — | — | 2 |
| Dementia | D003704 | EFO_0003862 | F03 | — | — | 1 | — | — | 1 |
| Psychophysiologic disorders | D011602 | — | F45.9 | — | — | 1 | — | — | 1 |
| Somatoform disorders | D013001 | — | F45 | — | — | 1 | — | — | 1 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | — | 1 | — | — | 1 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | — | — | 1 | — | — | 1 |
Indications Phases 2
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Crush injuries | D000071576 | — | T14.8 | 1 | — | — | — | — | 1 |
| Mental disorders | D001523 | EFO_0000677 | F91.9 | 1 | — | — | — | — | 1 |
| Prediabetic state | D011236 | EFO_1001121 | R73.03 | 1 | — | — | — | — | 1 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | 1 | — | — | — | — | 1 |
| Glucose intolerance | D018149 | HP_0000833 | R73.03 | 1 | — | — | — | — | 1 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | 1 | — | — | — | — | 1 |
| Marijuana abuse | D002189 | EFO_0007191 | F12 | 1 | — | — | — | — | 1 |
| Alcohol drinking | D000428 | EFO_0004329 | — | 1 | — | — | — | — | 1 |
| Therapeutic equivalency | D013810 | — | — | 1 | — | — | — | — | 1 |
| Hot flashes | D019584 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic pain | D059350 | — | — | — | — | — | — | 2 | 2 |
| Hypersensitivity | D006967 | EFO_0003785 | T78.40 | — | — | — | — | 1 | 1 |
| Circadian rhythm sleep disorders | D020178 | — | G47.2 | — | — | — | — | 1 | 1 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | — | — | — | — | 1 | 1 |
| Lung diseases | D008171 | EFO_0003818 | J98.4 | — | — | — | — | 1 | 1 |
| Hypoxia | D000860 | — | R09.02 | — | — | — | — | 1 | 1 |
| Cardiac arrhythmias | D001145 | EFO_0004269 | I49.9 | — | — | — | — | 1 | 1 |
| Hypercapnia | D006935 | — | — | — | — | — | — | 1 | 1 |
| Psychotic disorders | D011618 | — | F20.81 | — | — | — | — | 1 | 1 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Zopiclone |
| INN | zopiclone |
| Description | Zopiclone is a pyrrolo[3,4-b]pyrazine compound having a 4-methylpiperazine-1-carboxyl group at the 5-position, a 5-chloropyridin-2-yl group at the 6-position and an oxo-substituent at the 7-position. It has a role as a central nervous system depressant and a sedative. It is a pyrrolopyrazine and a monochloropyridine. |
| Classification | Small molecule |
| Drug class | hypnotics/tranquilizers (zopiclone type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN1CCN(C(=O)OC2c3nccnc3C(=O)N2c2ccc(Cl)cn2)CC1 |
Identifiers
| PDB | — |
| CAS-ID | 43200-80-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL135400 |
| ChEBI ID | 32315 |
| PubChem CID | 5735 |
| DrugBank | DB01198 |
| UNII ID | 03A5ORL08Q (ChemIDplus, GSRS) |
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Trends
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Safety
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Adverse Events
Top Adverse Reactions
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20,024 adverse events reported
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