Eylea(aflibercept)
Eylea, Zaltrap (aflibercept) is a protein pharmaceutical. Aflibercept was first approved as Eylea on 2011-11-18. It is used to treat diabetic retinopathy and macular edema in the USA. It has been approved in Europe to treat colorectal neoplasms, degenerative myopia, diabetes complications, diabetic retinopathy, and macular edema amongst others. The pharmaceutical is active against vascular endothelial growth factor A, long form.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Eylea, Zaltrap
Drug Products
FDA
EMA
Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Aflibercept
Tradename | Proper name | Company | Number | Date | Products |
|---|---|---|---|---|---|
| Eylea | aflibercept | Regeneron Pharmaceuticals | N-125387 RX | 2011-11-18 | 2 products |
| Zaltrap | Ziv-Aflibercept | Sanofi | N-125418 RX | 2012-08-03 | 2 products |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| diabetic retinopathy | EFO_0003770 | D003930 | — |
| macular edema | — | D008269 | — |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
aflibercept, Eylea, Regeneron Pharmaceuticals, Inc. | |||
| 2030-02-08 | Orphan excl. | ||
Patent Expiration
No data
ATC Codes
L: Antineoplastic and immunomodulating agents
— L01: Antineoplastic agents
— L01X: Other antineoplastic agents in atc
— L01XX: Other antineoplastic agents in atc
— L01XX44: Aflibercept
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01L: Ocular vascular disorder agents
— S01LA: Antineovascularisation agents
— S01LA05: Aflibercept
Clinical
Clinical Trials
528 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | 20 | 32 | 31 | 29 | 44 | 149 |
| Macular edema | D008269 | — | — | 9 | 21 | 30 | 28 | 28 | 109 |
| Colorectal neoplasms | D015179 | — | — | 5 | 25 | 6 | 1 | 5 | 39 |
| Retinal vein occlusion | D012170 | EFO_1001157 | H34.81 | 4 | 5 | 10 | 8 | 12 | 36 |
| Diabetic retinopathy | D003930 | EFO_0003770 | — | 2 | 10 | 2 | 5 | 5 | 23 |
| Wet macular degeneration | D057135 | EFO_0004683 | — | — | 3 | 6 | 5 | 7 | 20 |
| Polypoidal choroidal vasculopathy | D000092342 | — | — | — | — | — | 4 | 6 | 10 |
| Retinal diseases | D012164 | HP_0000479 | H35.9 | — | 3 | 2 | 1 | 2 | 8 |
| Retinal neovascularization | D015861 | — | H35.05 | — | 4 | — | 2 | 1 | 7 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | — | 3 | 1 | 1 | — | 5 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 13 | 2 | 1 | — | 2 | 17 |
| Choroidal neovascularization | D020256 | — | — | 1 | 2 | 2 | — | 4 | 9 |
| Eye diseases | D005128 | EFO_0003966 | H44 | 1 | 2 | 3 | — | 1 | 7 |
| Retinopathy of prematurity | D012178 | EFO_1001158 | H35.1 | — | — | 3 | — | 3 | 6 |
| Retinal degeneration | D012162 | HP_0001105 | — | — | 3 | 2 | — | — | 5 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 1 | 1 | 3 | — | — | 5 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 2 | 3 | 1 | — | — | 5 |
| Neovascular glaucoma | D015355 | EFO_1001060 | — | — | — | 2 | — | 3 | 5 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | 2 | 1 | — | — | 4 |
| Uveal neoplasms | D014604 | EFO_1001230 | — | — | 2 | 1 | — | — | 3 |
Show 9 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Rectal neoplasms | D012004 | — | — | — | 6 | — | — | 1 | 7 |
| Colonic neoplasms | D003110 | — | C18 | — | 3 | — | — | 2 | 5 |
| Melanoma | D008545 | — | — | 2 | 3 | — | — | — | 4 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 1 | 1 | — | — | 1 | 3 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 2 | 2 | — | — | — | 3 |
| Corneal neovascularization | D016510 | EFO_1000880 | H16.4 | 2 | 1 | — | — | — | 2 |
| Retinal detachment | D012163 | EFO_0005773 | H33.2 | — | 1 | — | — | 1 | 2 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 1 | — | — | — | 2 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | 1 | 1 | — | — | — | 2 |
| Esophageal neoplasms | D004938 | — | C15 | 1 | 1 | — | — | — | 2 |
Show 37 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | 2 | — | — | — | 1 | 3 |
| Glioma | D005910 | EFO_0000520 | — | 1 | — | — | — | 1 | 2 |
| Sarcoma | D012509 | — | — | 1 | — | — | — | — | 1 |
| Retinal arterial macroaneurysm | D000080346 | — | — | 1 | — | — | — | — | 1 |
| Neuroendocrine tumors | D018358 | EFO_1001901 | D3A.8 | 1 | — | — | — | — | 1 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myopia | D009216 | EFO_0003927 | H52.1 | — | — | — | — | 2 | 2 |
| Chorioretinitis | D002825 | HP_0012424 | H30 | — | — | — | — | 1 | 1 |
| Choroid diseases | D015862 | HP_0000610 | H31.9 | — | — | — | — | 1 | 1 |
| Sleep apnea syndromes | D012891 | HP_0010535 | G47.3 | — | — | — | — | 1 | 1 |
| Intravitreal injections | D058449 | — | — | — | — | — | — | 1 | 1 |
| Intraocular pressure | D007429 | — | — | — | — | — | — | 1 | 1 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Aflibercept |
| INN | aflibercept |
| Description | Aflibercept (immunoadhesin) |
| Classification | Protein |
| Drug class | receptor molecules or membrane ligands, natural, modified or modified: vascular endothelial growth factor (VEGF) receptors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1742982 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB08885 |
| UNII ID | 15C2VL427D (ChemIDplus, GSRS) |
Target
Agency Approved
VEGFA
VEGFA
Organism
Homo sapiens
Gene name
VEGFA
Gene synonyms
VEGF
NCBI Gene ID
Protein name
vascular endothelial growth factor A, long form
Protein synonyms
vascular endothelial growth factor A121, vascular endothelial growth factor A165, Vascular permeability factor, VPF
Uniprot ID
Mouse ortholog
Vegfa (22339)
vascular endothelial growth factor A, long form (Q6WZL9)
Alternate
No data
Variants
No data
Financial
Revenue by drug
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Eylea – Regeneron Pharmaceuticals
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Zaltrap – Regeneron Pharmaceuticals
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Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
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No Black-box warning
Adverse Events
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23,073 adverse events reported
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