Aflibercept
Ahzantive, Enzeevu, Eylea, Opuviz, Pavblu, Yesafili, Zaltrap (aflibercept) is a protein pharmaceutical. Aflibercept was first approved as Eylea on 2011-11-18. It is used to treat diabetic retinopathy and macular edema in the USA. It has been approved in Europe to treat colorectal neoplasms, degenerative myopia, diabetes complications, diabetic retinopathy, and macular edema amongst others. The pharmaceutical is active against vascular endothelial growth factor A, long form.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
aflibercept, Eylea, Regeneron Pharmaceuticals, Inc. | |||
| 2030-02-08 | Orphan excl. | ||
Patent Expiration
No data
ATC Codes
L: Antineoplastic and immunomodulating agents
— L01: Antineoplastic agents
— L01X: Other antineoplastic agents in atc
— L01XX: Other antineoplastic agents in atc
— L01XX44: Aflibercept
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01L: Ocular vascular disorder agents
— S01LA: Antineovascularisation agents
— S01LA05: Aflibercept
Clinical
Clinical Trials
561 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | 1 | 3 | 8 | 11 | 25 | 48 |
| Macular edema | D008269 | — | — | — | 4 | 9 | 8 | 11 | 31 |
| Edema | D004487 | — | R60.9 | — | 2 | 8 | 6 | 4 | 20 |
| Wet macular degeneration | D057135 | EFO_0004683 | — | — | — | 3 | 6 | 11 | 20 |
| Retinal vein occlusion | D012170 | EFO_1001157 | H34.81 | — | — | 4 | 1 | 7 | 12 |
| Choroidal neovascularization | D020256 | — | — | — | 1 | 1 | 1 | 3 | 6 |
| Pathologic neovascularization | D009389 | — | — | — | — | 1 | 1 | 3 | 5 |
| Polypoidal choroidal vasculopathy | D000092342 | — | — | — | — | — | 4 | 1 | 5 |
| Vascular diseases | D014652 | EFO_0004264 | I77 | — | — | — | 3 | 1 | 4 |
| Diabetic retinopathy | D003930 | EFO_0003770 | — | — | — | — | 1 | 1 | 2 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Retinal diseases | D012164 | — | H35.9 | — | — | 3 | — | 3 | 6 |
| Premature birth | D047928 | EFO_0003917 | O60 | — | — | 2 | — | 2 | 4 |
| Retinopathy of prematurity | D012178 | EFO_1001158 | H35.1 | — | — | 2 | — | 2 | 4 |
| Glaucoma | D005901 | EFO_0000516 | H40 | — | — | 2 | — | 1 | 3 |
| Neovascular glaucoma | D015355 | EFO_1001060 | — | — | — | 2 | — | 1 | 3 |
| Myopia | D009216 | EFO_0003927 | H52.1 | — | — | 1 | — | 1 | 2 |
| Eye diseases | D005128 | EFO_0003966 | H44 | — | — | 1 | — | 1 | 2 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | 1 | 2 | — | — | 2 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | — | 2 | — | — | 2 |
| Retinal degeneration | D012162 | — | — | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Colorectal neoplasms | D015179 | — | — | — | 1 | — | — | — | 1 |
| Retinitis pigmentosa | D012174 | — | H35.52 | — | 1 | — | — | — | 1 |
| Retinitis | D012173 | — | H30.9 | — | 1 | — | — | — | 1 |
Indications Phases 1
No data
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Retinal neovascularization | D015861 | — | H35.05 | — | — | — | — | 1 | 1 |
| Caregiver burden | D000084802 | — | — | — | — | — | — | 1 | 1 |
| Newborn infant diseases | D007232 | — | — | — | — | — | — | 1 | 1 |
| Uveitis | D014605 | EFO_1001231 | H20.9 | — | — | — | — | 1 | 1 |
| Inflammation | D007249 | MP_0001845 | — | — | — | — | — | 1 | 1 |
| Endophthalmitis | D009877 | — | — | — | — | — | — | 1 | 1 |
| Vision disorders | D014786 | — | H53.11 | — | — | — | — | 1 | 1 |
| Low vision | D015354 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Aflibercept |
| INN | aflibercept |
| Description | Aflibercept (immunoadhesin) |
| Classification | Protein |
| Drug class | receptor molecules or membrane ligands, natural, modified or modified: vascular endothelial growth factor (VEGF) receptors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1742982 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB08885 |
| UNII ID | 15C2VL427D (ChemIDplus, GSRS) |
Target
Agency Approved
VEGFA
VEGFA
Organism
Homo sapiens
Gene name
VEGFA
Gene synonyms
VEGF
NCBI Gene ID
Protein name
vascular endothelial growth factor A, long form
Protein synonyms
vascular endothelial growth factor A121, vascular endothelial growth factor A165, Vascular permeability factor, VPF
Uniprot ID
Mouse ortholog
Vegfa (22339)
vascular endothelial growth factor A, long form (Q6WZL9)
Alternate
No data
Variants
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Financial
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Eylea – Regeneron Pharmaceuticals
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Zaltrap – Regeneron Pharmaceuticals
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Tabular view
Estimated US medical usage
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 12,131 documents
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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28,737 adverse events reported
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