Aflibercept
Ahzantive, Enzeevu, Eylea, Opuviz, Pavblu, Yesafili, Zaltrap (aflibercept) is a protein pharmaceutical. Aflibercept was first approved as Eylea on 2011-11-18. It is used to treat diabetic retinopathy and macular edema in the USA. It has been approved in Europe to treat colorectal neoplasms, degenerative myopia, diabetes complications, diabetic retinopathy, and macular edema amongst others. The pharmaceutical is active against vascular endothelial growth factor A, long form.
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Commercial
Therapeutic Areas
Trade Name
FDA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
aflibercept, Eylea, Regeneron Pharmaceuticals, Inc. | |||
| 2030-02-08 | Orphan excl. | ||
Patent Expiration
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ATC Codes
L: Antineoplastic and immunomodulating agents
— L01: Antineoplastic agents
— L01X: Other antineoplastic agents in atc
— L01XX: Other antineoplastic agents in atc
— L01XX44: Aflibercept
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01L: Ocular vascular disorder agents
— S01LA: Antineovascularisation agents
— S01LA05: Aflibercept
Clinical
Clinical Trials
540 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | 28 | 46 | 46 | 41 | 59 | 207 |
| Macular edema | D008269 | — | — | 14 | 29 | 41 | 42 | 39 | 155 |
| Edema | D004487 | HP_0000969 | R60.9 | 8 | 19 | 33 | 29 | 26 | 110 |
| Wet macular degeneration | D057135 | EFO_0004683 | — | 14 | 20 | 28 | 15 | 20 | 92 |
| Retinal vein occlusion | D012170 | EFO_1001157 | H34.81 | 4 | 5 | 11 | 11 | 15 | 43 |
| Retinal diseases | D012164 | HP_0000479 | H35.9 | 5 | 19 | 8 | 5 | 10 | 42 |
| Colorectal neoplasms | D015179 | — | — | 6 | 27 | 6 | 1 | 5 | 41 |
| Diabetic retinopathy | D003930 | EFO_0003770 | — | 4 | 19 | 5 | 6 | 8 | 37 |
| Choroidal neovascularization | D020256 | — | — | 3 | 10 | 3 | 4 | 10 | 28 |
| Pathologic neovascularization | D009389 | — | — | 3 | 6 | 3 | 3 | 8 | 22 |
Show 16 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 16 | 5 | 3 | — | 2 | 24 |
| Carcinoma | D002277 | — | C80.0 | 5 | 6 | 1 | — | — | 10 |
| Glaucoma | D005901 | EFO_0000516 | H40 | 1 | — | 4 | — | 3 | 8 |
| Eye diseases | D005128 | EFO_0003966 | H44 | 1 | 3 | 2 | — | 1 | 7 |
| Melanoma | D008545 | — | — | 2 | 5 | 1 | — | — | 7 |
| Premature birth | D047928 | EFO_0003917 | O60 | — | — | 3 | — | 4 | 7 |
| Retinopathy of prematurity | D012178 | EFO_1001158 | H35.1 | — | — | 3 | — | 4 | 7 |
| Neovascular glaucoma | D015355 | EFO_1001060 | — | — | — | 3 | — | 3 | 6 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 3 | 4 | 1 | — | — | 6 |
| Myopia | D009216 | EFO_0003927 | H52.1 | — | — | 1 | — | 4 | 5 |
Show 12 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Recurrence | D012008 | — | — | 2 | 10 | — | — | 2 | 13 |
| Rectal neoplasms | D012004 | — | — | — | 6 | — | — | 1 | 7 |
| Inflammation | D007249 | MP_0001845 | — | 1 | 2 | — | — | 4 | 6 |
| Colonic neoplasms | D003110 | — | C18 | — | 3 | — | — | 2 | 5 |
| Adenocarcinoma | D000230 | — | — | — | 5 | — | — | — | 5 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 2 | 2 | — | — | 1 | 4 |
| Ovarian epithelial carcinoma | D000077216 | — | — | 2 | 3 | — | — | — | 4 |
| Glioma | D005910 | EFO_0000520 | — | 1 | 1 | — | — | 1 | 3 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | 2 | 2 | — | — | — | 3 |
| Esophageal neoplasms | D004938 | — | C15 | 2 | 2 | — | — | — | 3 |
Show 72 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | 5 | — | — | — | 1 | 6 |
| Biliary tract neoplasms | D001661 | — | C24.9 | 1 | — | — | — | — | 1 |
| Optic nerve injuries | D020221 | — | S04.01 | 1 | — | — | — | — | 1 |
| Retinal arterial macroaneurysm | D000080346 | — | — | 1 | — | — | — | — | 1 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 1 | — | — | — | — | 1 |
| B-cell lymphoma | D016393 | — | — | 1 | — | — | — | — | 1 |
| Dyslipidemias | D050171 | HP_0003119 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chorioretinitis | D002825 | HP_0012424 | H30 | — | — | — | — | 1 | 1 |
| Choroid diseases | D015862 | HP_0000610 | H31.9 | — | — | — | — | 1 | 1 |
| Obstructive sleep apnea | D020181 | EFO_0003918 | G47.33 | — | — | — | — | 1 | 1 |
| Sleep apnea syndromes | D012891 | HP_0010535 | G47.3 | — | — | — | — | 1 | 1 |
| Apnea | D001049 | HP_0002104 | R06.81 | — | — | — | — | 1 | 1 |
| Caregiver burden | D000084802 | — | — | — | — | — | — | 1 | 1 |
| Central nervous system neoplasms | D016543 | — | — | — | — | — | — | 1 | 1 |
| Nervous system neoplasms | D009423 | — | — | — | — | — | — | 1 | 1 |
| Intravitreal injections | D058449 | — | — | — | — | — | — | 1 | 1 |
| Hemangioma | D006391 | — | D18.0 | — | — | — | — | 1 | 1 |
Show 9 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Aflibercept |
| INN | aflibercept |
| Description | Aflibercept (immunoadhesin) |
| Classification | Protein |
| Drug class | receptor molecules or membrane ligands, natural, modified or modified: vascular endothelial growth factor (VEGF) receptors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1742982 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB08885 |
| UNII ID | 15C2VL427D (ChemIDplus, GSRS) |
Target
Agency Approved
VEGFA
VEGFA
Organism
Homo sapiens
Gene name
VEGFA
Gene synonyms
VEGF
NCBI Gene ID
Protein name
vascular endothelial growth factor A, long form
Protein synonyms
vascular endothelial growth factor A121, vascular endothelial growth factor A165, Vascular permeability factor, VPF
Uniprot ID
Mouse ortholog
Vegfa (22339)
vascular endothelial growth factor A, long form (Q6WZL9)
Alternate
No data
Variants
No data
Financial
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Eylea – Regeneron Pharmaceuticals
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Zaltrap – Regeneron Pharmaceuticals
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Tabular view
Estimated US medical usage
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Trends
PubMed Central
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Additional graphs summarizing 11,334 documents
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Safety
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Adverse Events
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27,552 adverse events reported
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