Aflibercept
Ahzantive, Enzeevu, Eylea, Opuviz, Pavblu, Yesafili, Zaltrap (aflibercept) is a protein pharmaceutical. Aflibercept was first approved as Eylea on 2011-11-18. It is used to treat diabetic retinopathy and macular edema in the USA. It has been approved in Europe to treat colorectal neoplasms, degenerative myopia, diabetes complications, diabetic retinopathy, and macular edema amongst others. The pharmaceutical is active against vascular endothelial growth factor A, long form.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
aflibercept, Eylea, Regeneron Pharmaceuticals, Inc. | |||
| 2030-02-08 | Orphan excl. | ||
Patent Expiration
No data
ATC Codes
L: Antineoplastic and immunomodulating agents
— L01: Antineoplastic agents
— L01X: Other antineoplastic agents in atc
— L01XX: Other antineoplastic agents in atc
— L01XX44: Aflibercept
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01L: Ocular vascular disorder agents
— S01LA: Antineovascularisation agents
— S01LA05: Aflibercept
Clinical
Clinical Trials
547 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | 4 | 6 | 7 | 11 | 14 | 42 |
| Macular edema | D008269 | — | — | 5 | 5 | 13 | 10 | 6 | 37 |
| Edema | D004487 | HP_0000969 | R60.9 | 2 | 2 | 10 | 7 | 2 | 23 |
| Wet macular degeneration | D057135 | EFO_0004683 | — | 2 | 2 | 4 | 6 | 7 | 21 |
| Retinal diseases | D012164 | HP_0000479 | H35.9 | 3 | 7 | 7 | 2 | 1 | 16 |
| Retinal vein occlusion | D012170 | EFO_1001157 | H34.81 | 1 | 1 | 4 | 3 | 4 | 12 |
| Diabetic retinopathy | D003930 | EFO_0003770 | — | 2 | 6 | 4 | 2 | 1 | 11 |
| Choroidal neovascularization | D020256 | — | — | — | 1 | 1 | 1 | 1 | 4 |
| Retinal detachment | D012163 | EFO_0005773 | H33.2 | — | — | — | 3 | — | 3 |
| Vascular diseases | D014652 | EFO_0004264 | I77 | — | — | — | 3 | — | 3 |
Show 3 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 12 | 3 | 3 | — | — | 17 |
| Colorectal neoplasms | D015179 | — | — | 2 | 4 | 4 | — | — | 9 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 1 | — | 4 | — | — | 5 |
| Premature birth | D047928 | EFO_0003917 | O60 | — | — | 3 | — | 1 | 4 |
| Retinopathy of prematurity | D012178 | EFO_1001158 | H35.1 | — | — | 3 | — | 1 | 4 |
| Pathologic neovascularization | D009389 | — | — | 1 | — | 1 | — | 1 | 3 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 1 | 2 | 1 | — | — | 3 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | — | 3 | 1 | — | — | 3 |
| Carcinoma | D002277 | — | C80.0 | 1 | 1 | 1 | — | — | 2 |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | 1 | 1 | — | — | 2 |
Show 11 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Eye diseases | D005128 | EFO_0003966 | H44 | — | 1 | — | — | 1 | 2 |
| Radiation injuries | D011832 | — | — | 1 | 1 | — | — | — | 2 |
| Melanoma | D008545 | — | — | — | 2 | — | — | — | 2 |
| Uveal neoplasms | D014604 | EFO_1001230 | — | — | 2 | — | — | — | 2 |
| Graves ophthalmopathy | D049970 | EFO_1001466 | — | — | 1 | — | — | — | 1 |
| Thyroid diseases | D013959 | HP_0000820 | E00-E07 | — | 1 | — | — | — | 1 |
| Lung diseases | D008171 | HP_0002088 | J98.4 | — | 1 | — | — | — | 1 |
| Adenocarcinoma | D000230 | — | — | — | 1 | — | — | — | 1 |
| Adenocarcinoma of lung | D000077192 | — | — | — | 1 | — | — | — | 1 |
| Ovarian epithelial carcinoma | D000077216 | — | — | — | 1 | — | — | — | 1 |
Show 2 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | 5 | — | — | — | — | 5 |
| Corneal neovascularization | D016510 | EFO_1000880 | H16.4 | 1 | — | — | — | — | 1 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 1 | — | — | — | — | 1 |
| B-cell lymphoma | D016393 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Caregiver burden | D000084802 | — | — | — | — | — | — | 1 | 1 |
| Hemangioma | D006391 | — | D18.0 | — | — | — | — | 1 | 1 |
| Uveitis | D014605 | HP_0000554 | H20.9 | — | — | — | — | 1 | 1 |
| Inflammation | D007249 | MP_0001845 | — | — | — | — | — | 1 | 1 |
| Endophthalmitis | D009877 | — | — | — | — | — | — | 1 | 1 |
| Vision disorders | D014786 | HP_0000505 | H53.11 | — | — | — | — | 1 | 1 |
| Low vision | D015354 | — | — | — | — | — | — | 1 | 1 |
| Vasculitis | D014657 | HP_0002633 | — | — | — | — | — | 1 | 1 |
| Retinal vasculitis | D031300 | EFO_1001156 | H35.06 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Aflibercept |
| INN | aflibercept |
| Description | Aflibercept (immunoadhesin) |
| Classification | Protein |
| Drug class | receptor molecules or membrane ligands, natural, modified or modified: vascular endothelial growth factor (VEGF) receptors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1742982 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB08885 |
| UNII ID | 15C2VL427D (ChemIDplus, GSRS) |
Target
Agency Approved
VEGFA
VEGFA
Organism
Homo sapiens
Gene name
VEGFA
Gene synonyms
VEGF
NCBI Gene ID
Protein name
vascular endothelial growth factor A, long form
Protein synonyms
vascular endothelial growth factor A121, vascular endothelial growth factor A165, Vascular permeability factor, VPF
Uniprot ID
Mouse ortholog
Vegfa (22339)
vascular endothelial growth factor A, long form (Q6WZL9)
Alternate
No data
Variants
No data
Financial
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Zaltrap – Regeneron Pharmaceuticals
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Eylea – Regeneron Pharmaceuticals
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Estimated US medical usage
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Trends
PubMed Central
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Additional graphs summarizing 11,662 documents
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Safety
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Adverse Events
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28,339 adverse events reported
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