Ziritaxestat
Ziritaxestat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against autotaxin.
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Commercial
No data
Clinical
Clinical Trials
9 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Fibrosis | D005355 | — | — | — | 1 | 2 | — | — | 3 |
| Idiopathic pulmonary fibrosis | D054990 | — | J84.112 | — | 1 | 2 | — | — | 3 |
| Pulmonary fibrosis | D011658 | — | — | — | 1 | 2 | — | — | 3 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Systemic scleroderma | D012595 | EFO_0000717 | M34.0 | — | 2 | — | — | — | 2 |
| Diffuse scleroderma | D045743 | EFO_0000404 | — | — | 2 | — | — | — | 2 |
| Sclerosis | D012598 | — | — | — | 2 | — | — | — | 2 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 4 | — | — | — | — | 4 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Ziritaxestat |
| INN | ziritaxestat |
| Description | Ziritaxestat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against ectonucleotide pyrophosphatase/phosphodiesterase family member 2. |
| Classification | Small molecule |
| Drug class | enzyme inhibitors: autotaxin inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCc1nc2c(C)cc(N3CCN(CC(=O)N4CC(O)C4)CC3)cn2c1N(C)c1nc(-c2ccc(F)cc2)c(C#N)s1 |
Identifiers
| PDB | — |
| CAS-ID | 1628260-79-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3828074 |
| ChEBI ID | — |
| PubChem CID | 90420193 |
| DrugBank | DB15403 |
| UNII ID | I02418V13W (ChemIDplus, GSRS) |
Target
Agency Approved
ENPP2
ENPP2
Organism
Homo sapiens
Gene name
ENPP2
Gene synonyms
ATX, PDNP2
NCBI Gene ID
Protein name
autotaxin; ectonucleotide pyrophosphatase/phosphodiesterase family member 2
Protein synonyms
autotaxin-t, E-NPP 2, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, Extracellular lysophospholipase D, LysoPLD, phosphodiesterase I/nucleotide pyrophosphatase 2, plasma lysophospholipase D
Uniprot ID
Mouse ortholog
Enpp2 (18606)
autotaxin; ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Q9R1E6)
Alternate
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 223 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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