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Drug ReportsZiprasidone
Ziprasidone
Geodon, Ziprasidone (ziprasidone) is a small molecule pharmaceutical. Ziprasidone was first approved as Geodon on 2001-02-05. It is used to treat schizophrenia, schizophrenia spectrum and other psychotic disorders, and tourette syndrome in the USA. The pharmaceutical is active against 5-hydroxytryptamine receptor 2C, 5-hydroxytryptamine receptor 2A, and D(2) dopamine receptor. In addition, it is known to target sodium-dependent serotonin transporter, 5-hydroxytryptamine receptor 1B, 5-hydroxytryptamine receptor 1D, 5-hydroxytryptamine receptor 1A, histamine H1 receptor, 5-hydroxytryptamine receptor 1E, 5-hydroxytryptamine receptor 7, and sodium-dependent noradrenaline transporter.
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Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
hereditary congenital and neonatal diseases and abnormalitiesD009358
mental disordersD001523
Trade Name
FDA
EMA
Geodon, Ziprasidone (discontinued: Geodon, Ziprasidone)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ziprasidone hydrochloride
Tradename
Company
Number
Date
Products
GEODONViatrisN-020825 RX2001-02-05
4 products, RLD
Show 1 discontinued
Ziprasidone mesylate
Tradename
Company
Number
Date
Products
GEODONViatrisN-020919 RX2002-06-21
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
geodonNew Drug Application2025-01-13
ziprasidoneANDA2025-10-10
ziprasidone hydrochlorideANDA2025-08-26
ziprasidone mesylateANDA2025-09-16
ziprasidone ziprasidoneANDA2023-08-07
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
tourette syndromeEFO_0004895D005879F95.2
schizophreniaEFO_0000692D012559F20
schizophrenia spectrum and other psychotic disorders—D019967—
Agency Specific
FDA
EMA
Expiration
Code
ZIPRASIDONE HYDROCHLORIDE, GEODON, VIATRIS
2025-01-28M-232
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N05: Psycholeptics
— N05A: Antipsychotics
— N05AE: Indole derivatives, antipsychotic
— N05AE04: Ziprasidone
HCPCS
Code
Description
J3486
Injection, ziprasidone mesylate, 10 mg
Clinical
Clinical Trials
159 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———2————2
MalnutritionD044342EFO_0008572E40-E461————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameZiprasidone
INNziprasidone
Description
Ziprasidone is a piperazine compound having 1,2-benzothiazol-3-yl- and 2-(6-chloro-1,3-dihydro-2-oxindol-5-yl)ethyl substituents attached to the nitrogen atoms. It has a role as a psychotropic drug, a histamine antagonist, a muscarinic antagonist, a serotonergic antagonist, a dopaminergic antagonist and an antipsychotic agent. It is a member of piperazines, an organochlorine compound, a member of indolones and a 1,2-benzisothiazole.
Classification
Small molecule
Drug classantipsychotic with binding activity on sertonin (5-HT2A) and dopamine (D2) receptors
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
O=C1Cc2cc(CCN3CCN(c4nsc5ccccc45)CC3)c(Cl)cc2N1
Identifiers
PDB—
CAS-ID146939-27-7
RxCUI—
ChEMBL IDCHEMBL708
ChEBI ID10119
PubChem CID60854
DrugBankDB00246
UNII ID6UKA5VEJ6X (ChemIDplus, GSRS)
Target
Agency Approved
HTR2C
HTR2C
HTR2A
HTR2A
DRD2
DRD2
Organism
Homo sapiens
Gene name
HTR2C
Gene synonyms
HTR1C
NCBI Gene ID
3358
Protein name
5-hydroxytryptamine receptor 2C
Protein synonyms
5-HT-1C, 5-HT1C, 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled, 5-hydroxytryptamine receptor 1C, serotonin 5-HT-1C receptor, serotonin 5-HT-2C receptor, Serotonin receptor 2C
Uniprot ID
Q9NP28
Mouse ortholog
Htr2c (15560)
5-hydroxytryptamine receptor 2C (Q5WRU6)
Alternate
SLC6A4
SLC6A4
HTR1B
HTR1B
HTR1D
HTR1D
HTR1A
HTR1A
HRH1
HRH1
HTR1E
HTR1E
HTR7
HTR7
SLC6A2
SLC6A2
Organism
Homo sapiens
Gene name
SLC6A4
Gene synonyms
HTT, SERT
NCBI Gene ID
6532
Protein name
sodium-dependent serotonin transporter
Protein synonyms
5-hydroxytryptamine (serotonin) transporter, 5HT transporter, 5HTT, Na+/Cl- dependent serotonin transporter, serotonin transporter 1, solute carrier family 6 (neurotransmitter transporter), member 4, solute carrier family 6 (neurotransmitter transporter, serotonin), member 4, Solute carrier family 6 member 4
Uniprot ID
Q5EE02
Mouse ortholog
Slc6a4 (15567)
sodium-dependent serotonin transporter (Q60857)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Geodon – Pfizer
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Estimated US medical usage
Ziprasidone
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 6,551 documents
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Safety
Black-box Warning
Black-box warning for: Geodon, Ziprasidone, Ziprasidone hydrochloride, Ziprasidone mesylate, Ziprasidone ziprasidone
Adverse Events
Top Adverse Reactions
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15,466 adverse events reported
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