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Drug ReportsZidovudine
Retrovir, Combivir(zidovudine)
/ Lamivudine / Zidovudine, Combivir, Lamivudine / Zidovudine, Retrovir, Trizivir, Zidovudine (zidovudine) is a small molecule pharmaceutical. Zidovudine was first approved as Retrovir on 1987-03-19. It is used to treat acquired immunodeficiency syndrome and HIV infections in the USA. It has been approved in Europe to treat HIV infections.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
urogenital diseasesD000091642
immune system diseasesD007154
Trade Name
FDA
EMA
Retrovir, Zidovudine (discontinued: Retrovir, Zidovudine)
Combinations
Abacavir sulfate, lamivudine zidovudine, Lamivudine zidovudine (discontinued: Combivir, Lamivudine zidovudine, Lamivudine, nevirapine zidovudine, Trizivir)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Zidovudine
Tradename
Company
Number
Date
Products
RETROVIRViiV HealthcareN-019655 RX1987-03-19
1 products, RLD, RS
RETROVIRViiV HealthcareN-019910 RX1989-09-28
1 products, RLD, RS
RETROVIRViiV HealthcareN-019951 RX1990-02-02
1 products, RLD, RS
Show 3 discontinued
Lamivudine
+
Nevirapine
+
Zidovudine
Tradename
Company
Number
Date
Products
LAMIVUDINE, NEVIRAPINE AND ZIDOVUDINEMicro LaboratoriesN-205626 DISCN2018-08-13
1 products, RLD
Hide discontinued
Lamivudine
+
Zidovudine
Tradename
Company
Number
Date
Products
LAMIVUDINE AND ZIDOVUDINEPharmaCareN-022018 DISCN2017-03-17
1 products
COMBIVIRViiV HealthcareN-020857 DISCN1997-09-26
1 products, RLD
Hide discontinued
Abacavir sulfate
+
Lamivudine
+
Zidovudine
Tradename
Company
Number
Date
Products
TRIZIVIRViiV HealthcareN-021205 DISCN2000-11-14
1 products, RLD
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
abacavir sulfate, lamivudine and zidovudineANDA2013-12-17
abacavir, lamivudine and zidovudineANDA2023-10-31
azactamNew Drug Application2025-01-09
aztreonamANDA2024-06-03
caystonNew Drug Application2025-03-17
combivirNew Drug Application2023-08-22
compound wC2002632025-08-08
compound w for kids one step stripsC2002632024-10-25
compound w one step padsC2002632024-10-25
compound w one step plantar foot padsC2002632024-10-25
Show 15 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
hiv infectionsEFO_0000764D015658B20
acquired immunodeficiency syndromeEFO_0000765D000163B20
hepatitis b—D006509—
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
J: Antiinfectives for systemic use
— J05: Antivirals for systemic use
— J05A: Direct acting antivirals
— J05AF: Nucleoside and nucleotide reverse transcriptase inhibitors
— J05AF01: Zidovudine
— J05AR: Antivirals for treatment of hiv infections, combinations
— J05AR01: Zidovudine and lamivudine
— J05AR04: Zidovudine, lamivudine and abacavir
— J05AR05: Zidovudine, lamivudine and nevirapine
HCPCS
Code
Description
J3485
Injection, zidovudine, 10 mg
S0104
Zidovudine, oral, 100 mg
Clinical
Clinical Trials
596 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hiv infectionsD015658EFO_0000764B20771179745124448
Acquired immunodeficiency syndromeD000163EFO_0000765B204242401362198
InfectionsD007239EFO_0000544—9101361755
HivD006678—O98.7712717542
Communicable diseasesD003141——6331821
LymphomaD008223—C85.911021316
LipodystrophyD008060—E88.1—3—7—10
TuberculosisD014376EFO_0000774A15-A19311239
Hepatitis cD006526—B19.232—137
Immunologic deficiency syndromesD007153—D84.9111227
Show 52 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Aids-related complexD000386EFO_0007137B20262513—3296
PregnancyD011247EFO_0002950Z33.1728—218
Aids-related opportunistic infectionsD017088——126—413
AnemiaD000740EFO_0004272D64.9—61—713
Kaposi sarcomaD012514—C46622——9
Non-hodgkin lymphomaD008228—C85.9—42—38
Aids dementia complexD015526EFO_0002608—223—18
Acne vulgarisD000152EFO_0003894L70—33—17
Infectious pregnancy complicationsD011251——4—3——7
Pneumocystis pneumoniaD011020EFO_0007448B59——4—37
Show 28 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Cytomegalovirus infectionsD003586EFO_0001062B2511——24
Lymphoproliferative disordersD008232Orphanet_2442D47.9—3———3
Progressive multifocal leukoencephalopathyD007968EFO_0007455A81.2—1——23
LymphadenopathyD000072281—R59.1—2———2
Non-small-cell lung carcinomaD002289——11———2
Lung neoplasmsD008175—C34.9011———2
Human herpesvirus 8D019288———2———2
InflammationD007249MP_0001845—21———2
T-cell lymphoma peripheralD016411———1——12
Epstein-barr virus infectionsD020031EFO_0000769——2———2
Show 37 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PancytopeniaD010198—D61.812———1012
CytopeniaD000095542——2———1012
Healthy volunteers/patients———5———27
NeutropeniaD009503—D702———13
PsoriasisD011565EFO_0000676L401———12
Breast neoplasmsD001943EFO_0003869C501———12
Polycystic ovary syndromeD011085EFO_0000660E28.21————1
Hiv seronegativityD018023——1————1
Newborn infant diseasesD007232——1————1
Mycobacterium avium-intracellulare infectionD015270EFO_0007386—1————1
Show 11 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Cytomegalovirus retinitisD017726EFO_1001302—————44
RetinitisD012173—H30.9————44
Chronic hepatitis cD019698EFO_0004220B18.2————11
Chronic hepatitis bD019694EFO_0004239B18.1————11
Chemical and drug induced liver injuryD056486EFO_0004228—————11
Meningeal tuberculosisD014390—A17.0————11
T-cell lymphomaD016399——————11
Brain neoplasmsD001932EFO_0003833C71————11
Myasthenia gravisD009157EFO_0004991G70.0————11
Bone fracturesD050723EFO_0003931T14.8————11
Show 27 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameZidovudine
INNzidovudine
Description
Zidovudine is a pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase. It has a role as an antiviral drug, an antimetabolite and a HIV-1 reverse transcriptase inhibitor. It is a pyrimidine 2',3'-dideoxyribonucleoside and an azide.
Classification
Small molecule
Drug classantineoplastics; antivirals (zidovudine group) (exception: edoxudine)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)[nH]c1=O
Identifiers
PDB—
CAS-ID30516-87-1
RxCUI—
ChEMBL IDCHEMBL129
ChEBI ID10110
PubChem CID35370
DrugBankDB00495
UNII ID4B9XT59T7S (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Azactam – Elan Corporation
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Estimated US medical usage
Zidovudine
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Lamivudine
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Abacavir
Total medical expenditures per year (USD, in millions)
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Zidovudine
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Lamivudine
Total medical expenditures per year (USD, in millions)
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Zidovudine
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,408,264 documents
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Safety
Black-box Warning
Black-box warning for: Abacavir sulfate, lamivudine and zidovudine, Abacavir, lamivudine and zidovudine, Combivir, Direct rx, Lamivudine and zidovudine, Lamivudine zidovudine, Retrovir, Trizivir, Zidovudine
Adverse Events
Top Adverse Reactions
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30,930 adverse events reported
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