Xylometazoline
Xylometazoline is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target alpha-1D adrenergic receptor.
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FDA approval date
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Patent expiration date
Study first post date
Last update post date
Start date
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Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| respiratory tract diseases | D012140 |
| otorhinolaryngologic diseases | D010038 |
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| metarivin soln. 0.1% | unapproved drug other | 2022-09-30 |
| sinosil | OTC monograph final | 2011-02-09 |
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
R: Respiratory system drugs
— R01: Nasal preparations
— R01A: Decongestants and other nasal preparations for topical use
— R01AA: Sympathomimetics, plain
— R01AA07: Xylometazoline
— R01AB: Sympathomimetics, combinations excl. corticosteroids
— R01AB06: Xylometazoline
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01G: Decongestants and antiallergics
— S01GA: Sympathomimetics used as decongestants
— S01GA03: Xylometazoline
— S01GA53: Xylometazoline, combinations
HCPCS
No data
Clinical
Clinical Trials
41 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
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Indications Phases 1
No data
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sinusitis | D012852 | EFO_0007486 | J32 | — | — | — | — | 1 | 1 |
| Rhinosinusitis | D000096825 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Xylometazoline |
| INN | xylometazoline |
| Description | Xylometazoline is an alkylbenzene. |
| Classification | Small molecule |
| Drug class | antihistamines/local vasoconstrictors (antazoline type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1cc(C(C)(C)C)cc(C)c1CC1=NCCN1 |
Identifiers
| PDB | — |
| CAS-ID | 526-36-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL312448 |
| ChEBI ID | 10082 |
| PubChem CID | 5709 |
| DrugBank | DB06694 |
| UNII ID | WPY40FTH8K (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
ADRA1D
ADRA1D
Organism
Homo sapiens
Gene name
ADRA1D
Gene synonyms
ADRA1A
NCBI Gene ID
Protein name
alpha-1D adrenergic receptor
Protein synonyms
adrenergic, alpha -1D-, receptor, adrenergic, alpha-1A-, receptor, Alpha-1A adrenergic receptor, Alpha-1D adrenoceptor, Alpha-1D adrenoreceptor, Alpha-adrenergic receptor 1a
Uniprot ID
Mouse ortholog
Adra1d (11550)
alpha-1D adrenergic receptor (Q61619)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 942 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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703 adverse events reported
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