Voxzogo(vosoritide)
Voxzogo (vosoritide) is a protein pharmaceutical. Vosoritide was first approved as Voxzogo on 2021-08-26. It is used to treat achondroplasia and dwarfism in the USA. It has been approved in Europe to treat achondroplasia. It is known to target atrial natriuretic peptide receptor 2.
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FDA approval date
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Voxzogo
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Vosoritide
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| VOXZOGO | BioMarin Pharmaceutical | N-214938 RX | 2021-11-19 | 3 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| voxzogo 0.4mg voxzogo 0.56mg voxzogo 1.2mg | New Drug Application | 2024-04-11 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| dwarfism | HP_0003510 | D004392 | E34.31 |
| achondroplasia | — | D000130 | Q77.4 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
VOSORITIDE, VOXZOGO, BIOMARIN PHARM | |||
| 2030-10-20 | ODE-449 | ||
| 2028-11-19 | ODE-387 | ||
| 2026-11-19 | NCE | ||
| 2026-10-20 | NPP | ||
HCPCS
No data
Clinical
Clinical Trials
15 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Achondroplasia | D000130 | — | Q77.4 | 2 | 5 | 3 | — | — | 10 |
| Dwarfism | D004392 | HP_0003510 | E34.31 | — | 4 | 1 | — | — | 5 |
| Lordosis | D008141 | HP_0003307 | M40.5 | — | — | 1 | — | — | 1 |
| Congenital limb deformities | D017880 | — | Q74.9 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Syndrome | D013577 | — | — | — | 2 | — | — | — | 2 |
| Turner syndrome | D014424 | Orphanet_881 | Q96 | — | 2 | — | — | — | 2 |
| Gonadal dysgenesis | D006059 | — | — | — | 2 | — | — | — | 2 |
| Mucopolysaccharidosis iv | D009085 | — | E76.210 | 1 | 1 | — | — | — | 1 |
| Noonan syndrome | D009634 | Orphanet_648 | Q87.19 | — | 1 | — | — | — | 1 |
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Vosoritide |
| INN | vosoritide |
| Description | Vosoritide, sold under the brand name Voxzogo, is a medication used for the treatment of achondroplasia.
|
| Classification | Protein |
| Drug class | peptides: atrial natriuretic type substances |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 1480724-61-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3707276 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB11928 |
| UNII ID | 7SE5582Q2P (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
NPR2
NPR2
Organism
Homo sapiens
Gene name
NPR2
Gene synonyms
ANPRB
NCBI Gene ID
Protein name
atrial natriuretic peptide receptor 2
Protein synonyms
ANP-B, ANPR-B, atrial natriuretic peptide B-type receptor, Atrial natriuretic peptide receptor type B, GC-B, guanylate cyclase 2B, Guanylate cyclase B, guanylyl cyclase B, natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B), NPR-B
Uniprot ID
Mouse ortholog
Npr2 (230103)
atrial natriuretic peptide receptor 2 (Q8CGA9)
Variants
No data
Financial
Revenue by drug
$
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£
â‚£
Voxzogo – BioMarin Pharmaceutical
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Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 169 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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361 adverse events reported
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