Trintellix, Brintellix(vortioxetine)
Brintellix, Trintellix (vortioxetine) is a small molecule pharmaceutical. Vortioxetine was first approved as Trintellix on 2013-09-30. It is used to treat major depressive disorder in the USA. It has been approved in Europe to treat major depressive disorder. The pharmaceutical is active against 5-hydroxytryptamine receptor 1B, sodium-dependent serotonin transporter, 5-hydroxytryptamine receptor 7, and 5-hydroxytryptamine receptor 1A. In addition, it is known to target 5-hydroxytryptamine receptor 5A, 5-hydroxytryptamine receptor 6, 5-hydroxytryptamine receptor 2A, and 5-hydroxytryptamine receptor 1D.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| mental disorders | D001523 |
Trade Name
FDA
EMA
Trintellix (discontinued: Trintellix, Vortioxetine)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| trintellix | New Drug Application | 2025-10-01 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| major depressive disorder | EFO_0003761 | D003865 | F22 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
VORTIOXETINE HYDROBROMIDE, TRINTELLIX, TAKEDA PHARMS USA | |||
| 2024-01-22 | M-187 | ||
| 2023-11-13 | M-267 | ||
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Vortioxetine Hydrobromide, Trintellix, Takeda Pharms Usa | |||
| 9278096 | 2032-03-21 | U-2436 | |
| 8722684 | 2031-06-30 | DS, DP | |
| 8969355 | 2027-06-15 | U-1668 | |
| 9125908 | 2027-06-15 | U-2309 | |
| 9125909 | 2027-06-15 | U-2309 | |
| 9125910 | 2027-06-15 | U-2309 | |
| 9227946 | 2027-06-15 | U-1668 | |
| 9861630 | 2027-06-15 | U-1668 | |
| 11458134 | 2027-06-15 | DP | U-3463 |
| 7144884 | 2026-06-17 | DS, DP | U-1439 |
HCPCS
No data
Clinical
Clinical Trials
112 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Major depressive disorder | D003865 | EFO_0003761 | F22 | 4 | 9 | 33 | 15 | 9 | 68 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | 6 | 10 | 30 | 17 | 5 | 65 |
| Depression | D003863 | — | F33.9 | 3 | 11 | 33 | 19 | 2 | 64 |
| Cognitive dysfunction | D060825 | — | G31.84 | 1 | 2 | 3 | 3 | — | 9 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | — | 2 | 6 | 2 | — | 9 |
| Healthy volunteers/patients | — | — | — | 4 | — | — | 1 | — | 5 |
| Recurrence | D012008 | — | — | — | — | 2 | 1 | — | 3 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | 1 | — | 1 | 1 | 3 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | 2 | — | 2 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | — | — | 2 | — | 2 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Generalized anxiety disorder | D000098647 | — | — | — | — | 5 | — | — | 5 |
| Mental disorders | D001523 | EFO_0000677 | F91.9 | — | 2 | 2 | — | — | 2 |
| Mood disorders | D019964 | EFO_0004247 | F30-F39 | — | — | 1 | — | — | 1 |
| Treatment outcome | D016896 | — | — | — | — | 1 | — | — | 1 |
| Head and neck neoplasms | D006258 | — | — | — | — | 1 | — | — | 1 |
| Radiation injuries | D011832 | — | T66 | — | — | 1 | — | — | 1 |
| Hoarding disorder | D000067836 | — | F42.3 | — | — | 1 | — | — | 1 |
| Marijuana abuse | D002189 | EFO_0007191 | F12 | — | 1 | 1 | — | — | 1 |
| Drug therapy | D004358 | — | — | — | 1 | 1 | — | — | 1 |
| Anxiety | D001007 | EFO_0005230 | F41.1 | — | 1 | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bulimia | D002032 | — | F50.2 | — | 1 | — | — | — | 1 |
| Feeding and eating disorders | D001068 | — | F50 | — | 1 | — | — | — | 1 |
| Binge-eating disorder | D056912 | — | F50.2 | — | 1 | — | — | — | 1 |
| Alcoholism | D000437 | EFO_0003829 | F10.1 | — | 1 | — | — | — | 1 |
| Hyperkinesis | D006948 | — | — | — | 1 | — | — | — | 1 |
| Attention deficit disorder with hyperactivity | D001289 | EFO_0003888 | F90 | — | 1 | — | — | — | 1 |
| Covid-19 | D000086382 | — | U07.1 | — | 1 | — | — | — | 1 |
| Disease | D004194 | EFO_0000408 | R69 | — | 1 | — | — | — | 1 |
| Syndrome | D013577 | — | — | — | 1 | — | — | — | 1 |
| Post-acute covid-19 syndrome | D000094024 | — | — | — | 1 | — | — | — | 1 |
Show 8 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cognition disorders | D003072 | — | — | 1 | — | — | — | — | 1 |
| Coronary disease | D003327 | — | — | 1 | — | — | — | — | 1 |
| Coronary artery disease | D003324 | — | I25.1 | 1 | — | — | — | — | 1 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | 1 | — | — | — | — | 1 |
| Pharmacokinetics | D010599 | — | — | 1 | — | — | — | — | 1 |
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | 1 | — | — | — | — | 1 |
| Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | — | — | 1 | 1 |
| Drug interactions | D004347 | — | — | — | — | — | — | 1 | 1 |
| Neoplasms | D009369 | — | C80 | — | — | — | — | 1 | 1 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | — | — | 1 | 1 |
| Magnetic resonance imaging | D008279 | — | — | — | — | — | — | 1 | 1 |
| Electroconvulsive therapy | D004565 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Vortioxetine |
| INN | vortioxetine |
| Description | Vortioxetine is an N-arylpiperazine in which the aryl group is specified as 2-[(2,4-dimethylphenyl)sulfanyl]phenyl. Used (as its hydrobromide salt) for treatment of major depressive disorder. It has a role as an antidepressant, an anxiolytic drug, a serotonergic agonist and a serotonergic antagonist. It is a N-arylpiperazine and an aryl sulfide. It is a conjugate base of a vortioxetine(1+). |
| Classification | Small molecule |
| Drug class | antidepressants (fluoxetine type): thioether derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1ccc(Sc2ccccc2N2CCNCC2)c(C)c1 |
Identifiers
| PDB | — |
| CAS-ID | 508233-74-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2104993 |
| ChEBI ID | 76016 |
| PubChem CID | 9966051 |
| DrugBank | DB09068 |
| UNII ID | 3O2K1S3WQV (ChemIDplus, GSRS) |
Target
Agency Approved
HTR1B
HTR1B
SLC6A4
SLC6A4
HTR7
HTR7
HTR1A
HTR1A
Organism
Homo sapiens
Gene name
HTR1B
Gene synonyms
HTR1DB
NCBI Gene ID
Protein name
5-hydroxytryptamine receptor 1B
Protein synonyms
5-HT-1D-beta, 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled, S12, Serotonin 1D beta receptor, Serotonin receptor 1B
Uniprot ID
Mouse ortholog
Htr1b (15551)
5-hydroxytryptamine receptor 1B (P28334)
Alternate
HTR5A
HTR5A
HTR6
HTR6
HTR2A
HTR2A
HTR1D
HTR1D
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Trintellix – Takeda
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Estimated US medical usage
Vortioxetine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 3,184 documents
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Safety
Black-box Warning
Black-box warning for: Trintellix
Adverse Events
Top Adverse Reactions
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16,712 adverse events reported
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