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Drug ReportsVortioxetine
Trintellix, Brintellix(vortioxetine)
Brintellix, Trintellix (vortioxetine) is a small molecule pharmaceutical. Vortioxetine was first approved as Trintellix on 2013-09-30. It is used to treat major depressive disorder in the USA. It has been approved in Europe to treat major depressive disorder. The pharmaceutical is active against 5-hydroxytryptamine receptor 1B, sodium-dependent serotonin transporter, 5-hydroxytryptamine receptor 7, and 5-hydroxytryptamine receptor 1A. In addition, it is known to target 5-hydroxytryptamine receptor 5A, 5-hydroxytryptamine receptor 6, 5-hydroxytryptamine receptor 2A, and 5-hydroxytryptamine receptor 1D.
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Drug
Target
Variants
Financial
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Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
mental disordersD001523
Trade Name
FDA
EMA
Trintellix (discontinued: Trintellix, Vortioxetine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Vortioxetine hydrobromide
Tradename
Company
Number
Date
Products
TRINTELLIXTakedaN-204447 RX2013-09-30
3 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
trintellixNew Drug Application2025-02-12
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
major depressive disorderEFO_0003761D003865F22
Agency Specific
FDA
EMA
Expiration
Code
VORTIOXETINE HYDROBROMIDE, TRINTELLIX, TAKEDA PHARMS USA
2024-01-22M-187
2023-11-13M-267
Patent Expiration
Patent
Expires
Flag
FDA Information
Vortioxetine Hydrobromide, Trintellix, Takeda Pharms Usa
92780962032-03-21U-2436
87226842031-06-30DS, DP
89693552027-06-15U-1668
91259082027-06-15U-2309
91259092027-06-15U-2309
91259102027-06-15U-2309
92279462027-06-15U-1668
98616302027-06-15U-1668
114581342027-06-15DPU-3463
71448842026-06-17DS, DPU-1439
ATC Codes
N: Nervous system drugs
— N06: Psychoanaleptics
— N06A: Antidepressants
— N06AX: Other antidepressants in atc
— N06AX26: Vortioxetine
HCPCS
No data
Clinical
Clinical Trials
110 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Depressive disorderD003866EFO_1002014F32.A16215134
DepressionD003863—F33.915215133
Major depressive disorderD003865EFO_0003761F22—4206131
Anxiety disordersD001008EFO_0006788F41.1—151—7
DementiaD003704EFO_0003862F03———1—1
Neurobehavioral manifestationsD019954EFO_0004364————1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Cognitive dysfunctionD060825—G31.84——3——3
RecurrenceD012008————2——2
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Bipolar disorderD001714EFO_0000289F30.9—1———1
HyperkinesisD006948———1———1
Attention deficit disorder with hyperactivityD001289EFO_0003888F90—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———2————2
PharmacokineticsD010599——1————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameVortioxetine
INNvortioxetine
Description
Vortioxetine is an N-arylpiperazine in which the aryl group is specified as 2-[(2,4-dimethylphenyl)sulfanyl]phenyl. Used (as its hydrobromide salt) for treatment of major depressive disorder. It has a role as an antidepressant, an anxiolytic drug, a serotonergic agonist and a serotonergic antagonist. It is a N-arylpiperazine and an aryl sulfide. It is a conjugate base of a vortioxetine(1+).
Classification
Small molecule
Drug classantidepressants (fluoxetine type): thioether derivatives
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
Cc1ccc(Sc2ccccc2N2CCNCC2)c(C)c1
Identifiers
PDB—
CAS-ID508233-74-7
RxCUI—
ChEMBL IDCHEMBL2104993
ChEBI ID76016
PubChem CID9966051
DrugBankDB09068
UNII ID3O2K1S3WQV (ChemIDplus, GSRS)
Target
Agency Approved
HTR1B
HTR1B
SLC6A4
SLC6A4
HTR7
HTR7
HTR1A
HTR1A
Organism
Homo sapiens
Gene name
HTR1B
Gene synonyms
HTR1DB
NCBI Gene ID
3351
Protein name
5-hydroxytryptamine receptor 1B
Protein synonyms
5-HT-1D-beta, 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled, S12, Serotonin 1D beta receptor, Serotonin receptor 1B
Uniprot ID
Q4VAY7
Mouse ortholog
Htr1b (15551)
5-hydroxytryptamine receptor 1B (P28334)
Alternate
HTR5A
HTR5A
HTR6
HTR6
HTR2A
HTR2A
HTR1D
HTR1D
Organism
Homo sapiens
Gene name
HTR5A
Gene synonyms
NCBI Gene ID
3361
Protein name
5-hydroxytryptamine receptor 5A
Protein synonyms
5-HT-5, 5-HT-5A, 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled, Serotonin receptor 5A
Uniprot ID
Q2M2D2
Mouse ortholog
Htr5a (15563)
5-hydroxytryptamine receptor 5A (Q3URB0)
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Trintellix – Takeda
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Estimated US medical usage
Vortioxetine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 2,718 documents
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Safety
Black-box Warning
Black-box warning for: Trintellix
Adverse Events
Top Adverse Reactions
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15,650 adverse events reported
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