Vorinostat
Zolinza (vorinostat) is a small molecule pharmaceutical. Vorinostat was first approved as Zolinza on 2006-10-06. It is used to treat t-cell lymphoma cutaneous in the USA. The pharmaceutical is active against histone deacetylase 1. In addition, it is known to target histone deacetylase 8, histone deacetylase 11, histone deacetylase 6, polyamine deacetylase HDAC10, histone deacetylase 9, histone deacetylase 3, histone deacetylase 5, and histone deacetylase 2.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| neoplasms | D009369 |
| hemic and lymphatic diseases | D006425 |
| immune system diseases | D007154 |
Trade Name
FDA
EMA
Zolinza
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Vorinostat
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ZOLINZA | Merck & Co | N-021991 RX | 2006-10-06 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| zolinza | New Drug Application | 2024-11-12 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| t-cell lymphoma cutaneous | — | D016410 | C84.A |
Agency Specific
FDA
EMA
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HCPCS
No data
Clinical
Clinical Trials
282 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | 31 | 30 | 3 | — | 1 | 51 |
| Leukemia | D007938 | — | C95 | 20 | 17 | 1 | — | — | 31 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 18 | 12 | 1 | — | — | 28 |
| Multiple myeloma | D009101 | — | C90.0 | 15 | 10 | 2 | — | — | 23 |
| Non-small-cell lung carcinoma | D002289 | — | — | 17 | 11 | 1 | — | — | 23 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 17 | 9 | 1 | — | — | 22 |
| T-cell lymphoma | D016399 | — | — | 11 | 10 | 1 | — | 1 | 19 |
| Lung neoplasms | D008175 | — | C34.90 | 14 | 9 | 1 | — | 1 | 19 |
| Plasma cell neoplasms | D054219 | — | — | 10 | 8 | 2 | — | — | 17 |
| T-cell lymphoma cutaneous | D016410 | — | C84.A | 7 | 6 | 1 | — | 1 | 13 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 32 | 4 | — | — | — | 34 |
| Recurrence | D012008 | — | — | 19 | 16 | — | — | — | 32 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 15 | 14 | — | — | — | 24 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 11 | 13 | — | — | 3 | 22 |
| Myelodysplastic syndromes | D009190 | — | D46 | 12 | 11 | — | — | — | 20 |
| Myeloid leukemia | D007951 | — | C92 | 13 | 11 | — | — | — | 20 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 13 | 10 | — | — | — | 18 |
| Mantle-cell lymphoma | D020522 | — | C83.1 | 7 | 11 | — | — | — | 16 |
| Carcinoma | D002277 | — | C80.0 | 8 | 9 | — | — | — | 15 |
| Follicular lymphoma | D008224 | — | C82 | 8 | 9 | — | — | — | 14 |
Show 129 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Germ cell and embryonal neoplasms | D009373 | — | — | 5 | — | — | — | — | 5 |
| Medulloblastoma | D008527 | — | — | 4 | — | — | — | — | 4 |
| Oligodendroglioma | D009837 | EFO_0000631 | — | 4 | — | — | — | — | 4 |
| Primitive neuroectodermal tumors | D018242 | — | — | 3 | — | — | — | — | 3 |
| Pinealoma | D010871 | — | — | 3 | — | — | — | — | 3 |
| Plasmacytoma | D010954 | — | C90.3 | 3 | — | — | — | — | 3 |
| Esophageal neoplasms | D004938 | — | C15 | 2 | — | — | — | 1 | 3 |
| Adult t-cell leukemia-lymphoma | D015459 | — | C91.5 | 3 | — | — | — | — | 3 |
| T-cell leukemia | D015458 | — | — | 3 | — | — | — | — | 3 |
| Primary myelofibrosis | D055728 | — | D47.4 | 2 | — | — | — | — | 2 |
Show 52 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Depression | D003863 | — | F33.9 | — | — | — | — | 1 | 1 |
| Pruritus | D011537 | — | L29 | — | — | — | — | 1 | 1 |
| Triple negative breast neoplasms | D064726 | — | — | — | — | — | — | 1 | 1 |
| Autistic disorder | D001321 | EFO_0003758 | F84.0 | — | — | — | — | 1 | 1 |
| Conduct disorder | D019955 | EFO_0004216 | F91 | — | — | — | — | 1 | 1 |
| Autism spectrum disorder | D000067877 | — | F84.0 | — | — | — | — | 1 | 1 |
| Pervasive child development disorders | D002659 | EFO_0003756 | F84 | — | — | — | — | 1 | 1 |
| Pheochromocytoma | D010673 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Vorinostat |
| INN | vorinostat |
| Description | Vorinostat is a dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL). It has a role as an EC 3.5.1.98 (histone deacetylase) inhibitor, an apoptosis inducer and an antineoplastic agent. It is a hydroxamic acid and a dicarboxylic acid diamide. It is functionally related to a suberic acid, a hydroxylamine and an aniline. |
| Classification | Small molecule |
| Drug class | enzyme inhibitors: histone deacetylase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C(CCCCCCC(=O)Nc1ccccc1)NO |
Identifiers
| PDB | — |
| CAS-ID | 149647-78-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL98 |
| ChEBI ID | 45716 |
| PubChem CID | 5311 |
| DrugBank | DB02546 |
| UNII ID | 58IFB293JI (ChemIDplus, GSRS) |
Target
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Safety
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Adverse Events
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3,088 adverse events reported
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