Vorinostat
Zolinza (vorinostat) is a small molecule pharmaceutical. Vorinostat was first approved as Zolinza on 2006-10-06. It is used to treat t-cell lymphoma cutaneous in the USA. The pharmaceutical is active against histone deacetylase 1. In addition, it is known to target histone deacetylase 8, histone deacetylase 11, histone deacetylase 6, polyamine deacetylase HDAC10, histone deacetylase 9, histone deacetylase 3, histone deacetylase 5, and histone deacetylase 2.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| neoplasms | D009369 |
| hemic and lymphatic diseases | D006425 |
| immune system diseases | D007154 |
Trade Name
FDA
EMA
Zolinza
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Vorinostat
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ZOLINZA | Merck Sharp & Dohme | N-021991 RX | 2006-10-06 | 1 products, RLD, RS |
Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| t-cell lymphoma cutaneous | — | D016410 | C84.A |
Agency Specific
FDA
EMA
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HCPCS
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Clinical
Clinical Trials
276 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myeloid leukemia acute | D015470 | — | C92.0 | 17 | 11 | 1 | — | — | 26 |
| Lymphoma | D008223 | — | C85.9 | 17 | 10 | 1 | — | — | 22 |
| Non-small-cell lung carcinoma | D002289 | — | — | 17 | 11 | 1 | — | — | 22 |
| Multiple myeloma | D009101 | — | C90.0 | 13 | 9 | 2 | — | — | 20 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 15 | 7 | 1 | — | — | 19 |
| Astrocytoma | D001254 | EFO_0000271 | — | 5 | 2 | 1 | — | — | 6 |
| T-cell lymphoma cutaneous | D016410 | — | C84.A | 1 | 4 | 1 | — | 1 | 6 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 2 | 1 | 1 | — | 1 | 4 |
| Spinal cord neoplasms | D013120 | EFO_0003828 | C72.0 | 1 | 1 | 1 | — | — | 2 |
| Mesothelioma | D008654 | — | C45 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 28 | 4 | — | — | — | 30 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 11 | 13 | — | — | 3 | 22 |
| Myelodysplastic syndromes | D009190 | — | D46 | 12 | 10 | — | — | — | 19 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 12 | 8 | — | — | — | 18 |
| Mantle-cell lymphoma | D020522 | — | C83.1 | 7 | 8 | — | — | — | 13 |
| Glioblastoma | D005909 | EFO_0000515 | — | 9 | 8 | — | — | 1 | 13 |
| Follicular lymphoma | D008224 | — | C82 | 8 | 7 | — | — | — | 12 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 9 | 6 | — | — | — | 12 |
| Hodgkin disease | D006689 | — | C81 | 9 | 4 | — | — | — | 11 |
| Neuroblastoma | D009447 | EFO_0000621 | — | 6 | 3 | — | — | 1 | 10 |
Show 89 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Medulloblastoma | D008527 | — | — | 4 | — | — | — | — | 4 |
| Oligodendroglioma | D009837 | EFO_0000631 | — | 4 | — | — | — | — | 4 |
| Germ cell and embryonal neoplasms | D009373 | — | — | 3 | — | — | — | — | 3 |
| Plasma cell neoplasms | D054219 | — | — | 3 | — | — | — | — | 3 |
| Esophageal neoplasms | D004938 | — | C15 | 2 | — | — | — | 1 | 3 |
| Adult t-cell leukemia-lymphoma | D015459 | — | C91.5 | 3 | — | — | — | — | 3 |
| Primary myelofibrosis | D055728 | — | D47.4 | 2 | — | — | — | — | 2 |
| Leukemia myeloid chronic atypical bcr-abl negative | D054438 | — | C92.2 | 2 | — | — | — | — | 2 |
| Myelomonocytic leukemia juvenile | D054429 | — | C93.3 | 2 | — | — | — | — | 2 |
| Teratoma | D013724 | — | D28 | 2 | — | — | — | — | 2 |
Show 31 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Depression | D003863 | — | F33.9 | — | — | — | — | 1 | 1 |
| Pruritus | D011537 | HP_0000989 | L29 | — | — | — | — | 1 | 1 |
| Triple negative breast neoplasms | D064726 | — | — | — | — | — | — | 1 | 1 |
| Head and neck neoplasms | D006258 | — | — | — | — | — | — | 1 | 1 |
| Pheochromocytoma | D010673 | — | — | — | — | — | — | 1 | 1 |
| Paraganglioma | D010235 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Vorinostat |
| INN | vorinostat |
| Description | Vorinostat is a dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL). It has a role as an EC 3.5.1.98 (histone deacetylase) inhibitor, an apoptosis inducer and an antineoplastic agent. It is a hydroxamic acid and a dicarboxylic acid diamide. It is functionally related to a suberic acid, a hydroxylamine and an aniline. |
| Classification | Small molecule |
| Drug class | enzyme inhibitors: histone deacetylase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C(CCCCCCC(=O)Nc1ccccc1)NO |
Identifiers
| PDB | — |
| CAS-ID | 149647-78-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL98 |
| ChEBI ID | 45716 |
| PubChem CID | 5311 |
| DrugBank | DB02546 |
| UNII ID | 58IFB293JI (ChemIDplus, GSRS) |
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Safety
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Adverse Events
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2,843 adverse events reported
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