Vorasidenib
Voranigo (vorasidenib) is a small molecule pharmaceutical. Vorasidenib was first approved as Voranigo on 2024-08-06. It is used to treat oligodendroglioma in the USA. It is known to target isocitrate dehydrogenase [NADP], mitochondrial and isocitrate dehydrogenase [NADP] cytoplasmic.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
Voranigo
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| voranigo | New Drug Application | 2024-08-19 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| oligodendroglioma | EFO_0000631 | D009837 | — |
Agency Specific
FDA
EMA
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Patent Expiration
No data
ATC Codes
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HCPCS
No data
Clinical
Clinical Trials
15 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Glioma | D005910 | EFO_0000520 | — | 4 | 1 | 1 | — | 1 | 6 |
| Recurrence | D012008 | — | — | — | — | 1 | — | 1 | 2 |
Indications Phases 2
No data
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 5 | — | — | — | — | 5 |
| Neoplasms | D009369 | — | C80 | 2 | — | — | — | 1 | 3 |
| Myelodysplastic syndromes | D009190 | — | D46 | 2 | — | — | — | — | 2 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 2 | — | — | — | — | 2 |
| Hematologic neoplasms | D019337 | — | — | 2 | — | — | — | — | 2 |
| Myeloid leukemia | D007951 | — | C92 | 2 | — | — | — | — | 2 |
| Preleukemia | D011289 | — | — | 2 | — | — | — | — | 2 |
| Leukemia | D007938 | — | C95 | 1 | — | — | — | — | 1 |
| Myeloproliferative disorders | D009196 | — | D47.1 | 1 | — | — | — | — | 1 |
| Myelomonocytic leukemia chronic | D015477 | — | C93.1 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Germ cell and embryonal neoplasms | D009373 | — | — | — | — | — | — | 1 | 1 |
| Neoplasms by histologic type | D009370 | — | — | — | — | — | — | 1 | 1 |
| Glandular and epithelial neoplasms | D009375 | — | — | — | — | — | — | 1 | 1 |
| Nerve tissue neoplasms | D009380 | — | — | — | — | — | — | 1 | 1 |
| Primitive neuroectodermal tumors | D018242 | — | — | — | — | — | — | 1 | 1 |
| Neuroepithelial neoplasms | D018302 | — | — | — | — | — | — | 1 | 1 |
| Neuroectodermal tumors | D017599 | — | — | — | — | — | — | 1 | 1 |
| Disease attributes | D020969 | — | — | — | — | — | — | 1 | 1 |
| Pathologic processes | D010335 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Vorasidenib |
| INN | vorasidenib |
| Description | Vorasidenib is an experimental anti-cancer medication for the treatment of low-grade glioma. It is a small molecule inhibitor of isocitrate dehydrogenase-1 (IDH1) and isocitrate dehydrogenase-2 (IDH2), which are mutated in several forms of cancer. In a phase-III-trial, it was shown to prolong progression-free survival in patients with IDH1- or IDH2-mutant low-grade glioma.
|
| Classification | Small molecule |
| Drug class | mutated isocitrate dehydrogenase (IDH) inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@@H](Nc1nc(N[C@H](C)C(F)(F)F)nc(-c2cccc(Cl)n2)n1)C(F)(F)F |
Identifiers
| PDB | — |
| CAS-ID | 1644545-52-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4279047 |
| ChEBI ID | — |
| PubChem CID | 117817422 |
| DrugBank | DB17097 |
| UNII ID | 789Q85GA8P (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
IDH2
IDH2
IDH1
IDH1
Organism
Homo sapiens
Gene name
IDH2
Gene synonyms
NCBI Gene ID
Protein name
isocitrate dehydrogenase [NADP], mitochondrial
Protein synonyms
ICD-M, IDP, isocitrate dehydrogenase (NADP(+)) 2, mitochondrial, isocitrate dehydrogenase 2 (NADP+), mitochondrial, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase
Uniprot ID
Mouse ortholog
Idh2 (269951)
isocitrate dehydrogenase [NADP], mitochondrial (Q9EQK1)
Variants
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Financial
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Trends
PubMed Central
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Additional graphs summarizing 356 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
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