Vinpocetine
Vinpocetine is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A and dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C.
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Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
8 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Memory disorders | D008569 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ischemic stroke | D000083242 | — | — | — | 1 | 1 | — | — | 1 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | 1 | 1 | — | — | 1 |
| Inflammation | D007249 | MP_0001845 | — | — | 1 | 1 | — | — | 1 |
| Diabetic nephropathies | D003928 | EFO_0000401 | — | — | 1 | 1 | — | — | 1 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Epilepsy | D004827 | EFO_0000474 | G40.9 | 1 | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Fetal alcohol spectrum disorders | D063647 | — | Q86.0 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cerebral infarction | D002544 | — | I63 | — | — | — | — | 1 | 1 |
| Infarction | D007238 | EFO_0009463 | — | — | — | — | — | 1 | 1 |
| Biomedical enhancement | D024803 | — | — | — | — | — | — | 1 | 1 |
| Traumatic brain injuries | D000070642 | — | S06 | — | — | — | — | 1 | 1 |
| Brain injuries | D001930 | — | S06.9 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Vinpocetine |
| INN | vinpocetine |
| Description | Vinpocetine is an alkaloid. It has a role as a geroprotector. |
| Classification | Small molecule |
| Drug class | vinca alkaloids |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c(n1c1ccccc41)[C@@H]32 |
Identifiers
| PDB | — |
| CAS-ID | 42971-09-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL71752 |
| ChEBI ID | — |
| PubChem CID | 443955 |
| DrugBank | — |
| UNII ID | 543512OBTC (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
PDE1A
PDE1A
PDE1C
PDE1C
Organism
Homo sapiens
Gene name
PDE1A
Gene synonyms
NCBI Gene ID
Protein name
dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Protein synonyms
61 kDa Cam-PDE, calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A, calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase, hCam-1, phosphodiesterase 1A, calmodulin-dependent
Uniprot ID
Mouse ortholog
Pde1a (18573)
dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Q9JLL9)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,744 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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66 adverse events reported
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