Vinorelbine
Vinorelbine (vinorelbine) is a small molecule pharmaceutical. Vinorelbine was first approved as Navelbine on 1994-12-23. It is used to treat breast neoplasms, hodgkin disease, non-small-cell lung carcinoma, and ovarian neoplasms in the USA.
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Commercial
Trade Name
FDA
EMA
Vinorelbine (discontinued: Navelbine, Vinorelbine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Vinorelbine tartrate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| NAVELBINE | Laboratoires Pierre Fabre | N-020388 DISCN | 1994-12-23 | 1 products, RLD |
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FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| vinorelbine | ANDA | 2024-08-16 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| breast neoplasms | EFO_0003869 | D001943 | C50 |
| ovarian neoplasms | EFO_0003893 | D010051 | C56 |
| non-small-cell lung carcinoma | — | D002289 | — |
| hodgkin disease | — | D006689 | C81 |
Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
Code | Description |
|---|---|
| J9390 | Injection, vinorelbine tartrate, 10 mg |
Clinical
Clinical Trials
560 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 31 | 138 | 57 | 5 | 20 | 234 |
| Non-small-cell lung carcinoma | D002289 | — | — | 21 | 80 | 53 | 4 | 16 | 168 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 22 | 69 | 47 | 2 | 12 | 145 |
| Triple negative breast neoplasms | D064726 | — | — | 1 | 18 | 11 | 1 | 1 | 32 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 1 | 8 | 3 | 1 | — | 13 |
| Brain stem neoplasms | D020295 | EFO_1001767 | — | — | — | — | 1 | — | 1 |
| Meningeal carcinomatosis | D055756 | EFO_1001012 | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | 8 | 31 | 9 | — | 2 | 46 |
| Neoplasms | D009369 | — | C80 | 23 | 17 | 5 | — | 3 | 39 |
| Hodgkin disease | D006689 | — | C81 | 3 | 17 | 7 | — | 1 | 27 |
| Carcinoma | D002277 | — | C80.0 | 3 | 9 | 6 | — | 2 | 20 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 4 | 8 | 2 | — | — | 13 |
| Uterine cervical neoplasms | D002583 | HP_0030159 | — | 3 | 3 | 7 | — | — | 12 |
| Malignant mesothelioma | D000086002 | — | — | 1 | 7 | 3 | — | 1 | 12 |
| Mesothelioma | D008654 | — | C45 | 1 | 7 | 3 | — | 1 | 12 |
| Sarcoma | D012509 | — | — | 5 | 6 | 1 | — | 1 | 11 |
| Rhabdomyosarcoma | D012208 | — | — | 3 | 5 | 3 | — | — | 9 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prostatic neoplasms | D011471 | — | C61 | 4 | 9 | — | — | — | 11 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 6 | 3 | — | — | — | 8 |
| Ovarian epithelial carcinoma | D000077216 | — | — | 4 | 3 | — | — | — | 7 |
| B-cell lymphoma | D016393 | — | — | 1 | 5 | — | — | — | 5 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | — | 4 | — | — | — | 4 |
| Multiple myeloma | D009101 | — | C90.0 | 1 | 3 | — | — | — | 4 |
| Male breast neoplasms | D018567 | — | — | 2 | 1 | — | — | — | 3 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 3 | 1 | — | — | — | 3 |
| Leukemia | D007938 | — | C95 | 3 | 1 | — | — | — | 3 |
| Plasma cell neoplasms | D054219 | — | — | — | 3 | — | — | — | 3 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Endometrial neoplasms | D016889 | EFO_0004230 | — | 2 | — | — | — | — | 2 |
| Adrenocortical carcinoma | D018268 | — | — | 1 | — | — | — | — | 1 |
| Wilms tumor | D009396 | EFO_0000212 | — | 1 | — | — | — | — | 1 |
| Hematologic neoplasms | D019337 | — | — | 1 | — | — | — | — | 1 |
| Peritoneal neoplasms | D010534 | — | — | 1 | — | — | — | — | 1 |
| Urinary bladder neoplasms | D001749 | — | C67 | 1 | — | — | — | — | 1 |
| Vaginal neoplasms | D014625 | — | C52 | 1 | — | — | — | — | 1 |
| Gastrointestinal neoplasms | D005770 | — | C26.9 | 1 | — | — | — | — | 1 |
| Pheochromocytoma | D010673 | — | — | 1 | — | — | — | — | 1 |
| Skin neoplasms | D012878 | EFO_0004198 | C44 | 1 | — | — | — | — | 1 |
Show 11 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Methylation | D008745 | — | — | — | — | — | — | 1 | 1 |
| Multiple primary neoplasms | D009378 | — | — | — | — | — | — | 1 | 1 |
| Progression-free survival | D000077982 | — | — | — | — | — | — | 1 | 1 |
| Constipation | D003248 | HP_0002019 | K59.0 | — | — | — | — | 1 | 1 |
| Aggressive fibromatosis | D018222 | — | D48.11 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Vinorelbine |
| INN | vinorelbine |
| Description | Vinorelbine is a vinca alkaloid with a norvinblastine skeleton. It has a role as an antineoplastic agent and a photosensitizing agent. It is a vinca alkaloid, an organic heteropentacyclic compound, an organic heterotetracyclic compound, a methyl ester, an acetate ester and a ring assembly. |
| Classification | Small molecule |
| Drug class | vinca alkaloids |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C(=O)OC)(c1cc3c(cc1OC)N(C)[C@H]1[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]4(CC)C=CCN5CC[C@]31[C@@H]54)C2 |
Identifiers
| PDB | — |
| CAS-ID | 71486-22-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL553025 |
| ChEBI ID | 480999 |
| PubChem CID | 5311497 |
| DrugBank | DB00361 |
| UNII ID | Q6C979R91Y (ChemIDplus, GSRS) |
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Trends
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Additional graphs summarizing 16,307 documents
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Safety
Black-box Warning
Black-box warning for: Vinorelbine
Adverse Events
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10,007 adverse events reported
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