Vinflunine
Javlor (vinflunine) is a small molecule pharmaceutical. Vinflunine was first approved as Javlor on 2009-09-21. It has been approved in Europe to treat transitional cell carcinoma and urologic neoplasms.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| neoplasms | D009369 |
| urogenital diseases | D000091642 |
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Clinical
Clinical Trials
34 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Urinary bladder neoplasms | D001749 | — | C67 | 3 | 6 | 5 | — | — | 11 |
| Transitional cell carcinoma | D002295 | — | — | 1 | 7 | 4 | — | 1 | 10 |
| Carcinoma | D002277 | — | C80.0 | 1 | 4 | 4 | — | 1 | 8 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 2 | 4 | — | — | 6 |
| Ureteral neoplasms | D014516 | EFO_0003844 | C66 | 1 | 2 | 1 | — | — | 4 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | 3 | 2 | — | — | 4 |
| Head and neck neoplasms | D006258 | — | — | — | — | 1 | — | — | 1 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | — | — | 1 | — | — | 1 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 4 | 2 | — | — | — | 6 |
| Lung neoplasms | D008175 | — | C34.90 | — | 3 | — | — | — | 3 |
| Urologic neoplasms | D014571 | — | C64-C68 | 1 | 2 | — | — | — | 3 |
| Non-small-cell lung carcinoma | D002289 | — | — | — | 2 | — | — | — | 2 |
| Renal insufficiency | D051437 | — | N19 | 1 | 2 | — | — | — | 2 |
| Urethral neoplasms | D014523 | EFO_0003846 | — | 1 | 1 | — | — | — | 2 |
| Pelvic neoplasms | D010386 | — | — | 1 | 1 | — | — | — | 2 |
| Male breast neoplasms | D018567 | — | — | — | 1 | — | — | — | 1 |
| Penile neoplasms | D010412 | — | C60 | — | 1 | — | — | — | 1 |
| Urogenital neoplasms | D014565 | EFO_0003863 | D07 | — | 1 | — | — | — | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Vinflunine |
| INN | vinflunine |
| Description | Vinflunine is an organic heteropentacyclic compound and an organic heterotetracyclic compound that is vinorelbine in which the tetrahydropyridine moiety of the heterotetracyclic part of the molecule has been redced to the corresponding piperidine, and in which the ethyl group attached to this ring has been replaced by a 1,1-difluoroethyl group. It has a role as an antineoplastic agent. It is an organic heteropentacyclic compound, an organic heterotetracyclic compound, a semisynthetic derivative, a methyl ester, an acetate ester and a vinca alkaloid. It is functionally related to a vinorelbine. |
| Classification | Small molecule |
| Drug class | vinca alkaloids |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC[C@]12C=CCN3CC[C@@]4(c5cc([C@@]6(C(=O)OC)C[C@@H]7C[C@@H](C(C)(F)F)CN(Cc8c6[nH]c6ccccc86)C7)c(OC)cc5N(C)[C@H]4[C@@](O)(C(=O)OC)[C@@H]1OC(C)=O)[C@@H]32 |
Identifiers
| PDB | — |
| CAS-ID | 162652-95-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2110725 |
| ChEBI ID | 90241 |
| PubChem CID | 10629256 |
| DrugBank | DB11641 |
| UNII ID | 5BF646324K (ChemIDplus, GSRS) |
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Safety
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259 adverse events reported
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