Vinflunine
Javlor (vinflunine) is a small molecule pharmaceutical. Vinflunine was first approved as Javlor on 2009-09-21. It has been approved in Europe to treat transitional cell carcinoma and urologic neoplasms.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| neoplasms | D009369 |
| urogenital diseases | D000091642 |
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
34 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carcinoma | D002277 | — | C80.0 | 1 | 6 | 5 | — | 1 | 10 |
| Transitional cell carcinoma | D002295 | — | — | 1 | 7 | 4 | — | 1 | 10 |
| Urinary bladder neoplasms | D001749 | — | C67 | 3 | 5 | 4 | — | — | 9 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 2 | 4 | — | — | 6 |
| Neoplasms | D009369 | — | C80 | 4 | 1 | 1 | — | — | 6 |
| Ureteral neoplasms | D014516 | EFO_0003844 | C66 | 1 | 2 | 1 | — | — | 4 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | 1 | 2 | — | — | 2 |
| Head and neck neoplasms | D006258 | — | — | — | — | 1 | — | — | 1 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | — | — | 1 | — | — | 1 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | — | 3 | — | — | — | 3 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 1 | 2 | — | — | — | 2 |
| Urologic neoplasms | D014571 | — | C64-C68 | 1 | 1 | — | — | — | 2 |
| Urethral neoplasms | D014523 | EFO_0003846 | — | 1 | 1 | — | — | — | 2 |
| Pelvic neoplasms | D010386 | — | — | 1 | 1 | — | — | — | 2 |
| Penile neoplasms | D010412 | — | C60 | — | 1 | — | — | — | 1 |
| Prostatic neoplasms | D011471 | — | C61 | — | 1 | — | — | — | 1 |
| Small cell carcinoma | D018288 | — | — | — | 1 | — | — | — | 1 |
| Small cell lung carcinoma | D055752 | — | — | — | 1 | — | — | — | 1 |
| Non-small-cell lung carcinoma | D002289 | — | — | — | 1 | — | — | — | 1 |
Show 1 more
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Vinflunine |
| INN | vinflunine |
| Description | Vinflunine is an organic heteropentacyclic compound and an organic heterotetracyclic compound that is vinorelbine in which the tetrahydropyridine moiety of the heterotetracyclic part of the molecule has been redced to the corresponding piperidine, and in which the ethyl group attached to this ring has been replaced by a 1,1-difluoroethyl group. It has a role as an antineoplastic agent. It is an organic heteropentacyclic compound, an organic heterotetracyclic compound, a semisynthetic derivative, a methyl ester, an acetate ester and a vinca alkaloid. It is functionally related to a vinorelbine. |
| Classification | Small molecule |
| Drug class | vinca alkaloids |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC[C@]12C=CCN3CC[C@@]4(c5cc([C@@]6(C(=O)OC)C[C@@H]7C[C@@H](C(C)(F)F)CN(Cc8c6[nH]c6ccccc86)C7)c(OC)cc5N(C)[C@H]4[C@@](O)(C(=O)OC)[C@@H]1OC(C)=O)[C@@H]32 |
Identifiers
| PDB | — |
| CAS-ID | 162652-95-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2110725 |
| ChEBI ID | 90241 |
| PubChem CID | 10629256 |
| DrugBank | DB11641 |
| UNII ID | 5BF646324K (ChemIDplus, GSRS) |
Target
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 1,272 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
259 adverse events reported
View more details
© 2020-2024 Collaborative Drug Discovery Inc. (CDD) | Terms of Use