Vindesine
Vindesine is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Clinical Trials
83 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | 4 | 18 | 14 | 4 | 5 | 40 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | — | 6 | 10 | 5 | 1 | 21 |
| Leukemia | D007938 | — | C95 | — | 6 | 8 | 3 | 1 | 17 |
| Lymphoid leukemia | D007945 | — | C91 | — | 4 | 5 | 2 | — | 10 |
| B-cell lymphoma | D016393 | — | — | — | 2 | 5 | 1 | 1 | 9 |
| T-cell lymphoma | D016399 | — | — | 3 | 5 | — | 1 | 1 | 7 |
| T-cell lymphoma peripheral | D016411 | — | — | 3 | 5 | — | 1 | 1 | 7 |
| Burkitt lymphoma | D002051 | — | C83.7 | — | 2 | — | 1 | — | 3 |
| Aggression | D000374 | EFO_0003015 | — | — | — | 1 | 1 | — | 2 |
| Large-cell lymphoma anaplastic | D017728 | — | C84.6 | — | — | — | 1 | 1 | 2 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | — | 7 | 8 | — | 3 | 17 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 1 | 4 | 6 | — | 1 | 11 |
| Neuroblastoma | D009447 | EFO_0000621 | — | — | 1 | 4 | — | 1 | 6 |
| Lung neoplasms | D008175 | — | C34.90 | 1 | 2 | 3 | — | — | 6 |
| Hodgkin disease | D006689 | — | C81 | 1 | 3 | 2 | — | — | 5 |
| Follicular lymphoma | D008224 | — | C82 | — | 1 | 1 | — | 1 | 3 |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | — | 2 | — | — | 3 |
| Mantle-cell lymphoma | D020522 | — | C83.1 | — | — | 2 | — | — | 2 |
| Uterine cervical neoplasms | D002583 | — | — | — | — | 1 | — | — | 1 |
| Glioma | D005910 | EFO_0000520 | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Philadelphia chromosome | D010677 | — | — | — | 2 | — | — | — | 2 |
| Adult t-cell leukemia-lymphoma | D015459 | — | C91.5 | — | 2 | — | — | — | 2 |
| T-cell leukemia | D015458 | — | — | — | 1 | — | — | — | 1 |
| Central nervous system neoplasms | D016543 | — | — | — | 1 | — | — | — | 1 |
| Small cell lung carcinoma | D055752 | — | — | — | 1 | — | — | — | 1 |
| Pancoast syndrome | D010178 | — | — | — | 1 | — | — | — | 1 |
| Thyroid neoplasms | D013964 | EFO_0003841 | — | — | 1 | — | — | — | 1 |
| Thyroid diseases | D013959 | — | E00-E07 | — | 1 | — | — | — | 1 |
| Immunotherapy | D007167 | — | — | — | 1 | — | — | — | 1 |
| Precursor t-cell lymphoblastic leukemia-lymphoma | D054218 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Vindesine |
| INN | vindesine |
| Description | Vindesine is a vinca alkaloid, a methyl ester, an organic heterotetracyclic compound, an organic heteropentacyclic compound, a tertiary alcohol, a tertiary amino compound and a primary carboxamide. It has a role as an antineoplastic agent. It is functionally related to a vincaleukoblastine. |
| Classification | Small molecule |
| Drug class | vinca alkaloids |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC[C@]1(O)C[C@@H]2CN(CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C)[C@H]3[C@@](O)(C(N)=O)[C@H](O)[C@]5(CC)C=CCN6CC[C@]43[C@@H]65)C2)C1 |
Identifiers
| PDB | — |
| CAS-ID | 53643-48-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL238071 |
| ChEBI ID | — |
| PubChem CID | 40839 |
| DrugBank | DB00309 |
| UNII ID | RSA8KO39WH (ChemIDplus, GSRS) |
Target
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Safety
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2,310 adverse events reported
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