Vincristine
Vincristine (vincristine) is a small molecule pharmaceutical. Vincristine was first approved as Oncovin on 1982-01-01. It is used to treat hodgkin disease, leukemia, neuroblastoma, non-hodgkin lymphoma, and rhabdomyosarcoma amongst others in the USA. The pharmaceutical is active against tubulin beta chain.
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Vincristine (discontinued: Marqibo, Oncovin, Vincasar, Vincrex, Vincristine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Vincristine sulfate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| MARQIBO KIT | Acrotech Biopharma | N-202497 DISCN | 2012-08-09 | 1 products, RLD |
| ONCOVIN | Eli Lilly | N-014103 DISCN | 1982-01-01 | 3 products, RLD |
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FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| vincristine sulfate | ANDA | 2024-04-24 |
Indications
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Agency Specific
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Clinical
Clinical Trials
1364 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | 141 | 394 | 181 | 21 | 36 | 697 |
| Leukemia | D007938 | — | C95 | 69 | 161 | 75 | 17 | 22 | 303 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 58 | 141 | 73 | 23 | 23 | 287 |
| Lymphoid leukemia | D007945 | — | C91 | 53 | 132 | 61 | 18 | 15 | 248 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 56 | 145 | 52 | 5 | 9 | 233 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 58 | 115 | 56 | 7 | 10 | 217 |
| B-cell lymphoma | D016393 | — | — | 65 | 130 | 49 | 6 | 8 | 217 |
| Sarcoma | D012509 | — | — | 12 | 42 | 19 | 1 | 10 | 80 |
| Follicular lymphoma | D008224 | — | C82 | 19 | 32 | 30 | 2 | 3 | 75 |
| T-cell lymphoma | D016399 | — | — | 20 | 41 | 13 | 3 | 4 | 71 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neuroblastoma | D009447 | EFO_0000621 | — | 18 | 24 | 16 | — | 4 | 60 |
| Central nervous system neoplasms | D016543 | — | — | 9 | 22 | 15 | — | 5 | 49 |
| Nervous system neoplasms | D009423 | — | — | 7 | 21 | 13 | — | 5 | 44 |
| Ewing sarcoma | D012512 | EFO_0000173 | — | 7 | 23 | 7 | — | 4 | 36 |
| Recurrence | D012008 | — | — | 18 | 20 | 1 | — | 2 | 34 |
| Rhabdomyosarcoma | D012208 | — | — | 8 | 19 | 12 | — | 2 | 34 |
| Multiple myeloma | D009101 | — | C90.0 | 5 | 14 | 13 | — | 1 | 31 |
| Plasma cell neoplasms | D054219 | — | — | 3 | 10 | 12 | — | 1 | 26 |
| Precursor t-cell lymphoblastic leukemia-lymphoma | D054218 | — | — | 9 | 17 | 5 | — | — | 25 |
| Neuroectodermal tumors | D017599 | — | — | 1 | 10 | 7 | — | 3 | 21 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Plasmablastic lymphoma | D000069293 | — | C83.3 | 8 | 7 | — | — | — | 12 |
| Large-cell lymphoma immunoblastic | D016400 | — | — | 8 | 7 | — | — | — | 12 |
| Aids-related lymphoma | D016483 | EFO_1001365 | — | 4 | 8 | — | — | — | 12 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 3 | 7 | — | — | — | 9 |
| Hematologic neoplasms | D019337 | — | — | 5 | 2 | — | — | 2 | 8 |
| Blast crisis | D001752 | — | — | 1 | 6 | — | — | — | 7 |
| Reactive arthritis | D016918 | EFO_0007460 | M02.3 | — | 6 | — | — | — | 6 |
| Lymphoproliferative disorders | D008232 | Orphanet_2442 | D47.9 | 1 | 5 | — | — | — | 6 |
| Adult t-cell leukemia-lymphoma | D015459 | — | C91.5 | 3 | 3 | — | — | — | 5 |
| Vomiting | D014839 | — | R11.1 | — | 1 | — | — | 3 | 4 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pinealoma | D010871 | — | — | 2 | — | — | — | 1 | 3 |
| Myelodysplastic-myeloproliferative diseases | D054437 | — | — | 2 | — | — | — | — | 2 |
| Hypersensitivity | D006967 | EFO_0003785 | T78.40 | 1 | — | — | — | — | 1 |
| Deltaretrovirus infections | D006800 | EFO_1001303 | — | 1 | — | — | — | — | 1 |
| Htlv-i infections | D015490 | EFO_0007316 | — | 1 | — | — | — | — | 1 |
| Composite lymphoma | D058617 | — | — | 1 | — | — | — | — | 1 |
| Hematologic diseases | D006402 | EFO_0005803 | D75.9 | 1 | — | — | — | — | 1 |
| Mycoses | D009181 | — | B35-B49 | 1 | — | — | — | — | 1 |
| Sezary syndrome | D012751 | — | C84.1 | 1 | — | — | — | — | 1 |
| Mycosis fungoides | D009182 | — | C84.0 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | — | — | — | 6 | 6 |
| Nausea | D009325 | — | R11.0 | — | — | — | — | 3 | 3 |
| Constipation | D003248 | — | K59.0 | — | — | — | — | 2 | 2 |
| Cognitive dysfunction | D060825 | — | G31.84 | — | — | — | — | 1 | 1 |
| Non-small-cell lung carcinoma | D002289 | — | — | — | — | — | — | 1 | 1 |
| Ataxia | D001259 | — | R27.0 | — | — | — | — | 1 | 1 |
| Ataxia telangiectasia | D001260 | Orphanet_100 | G11.3 | — | — | — | — | 1 | 1 |
| Telangiectasis | D013684 | — | — | — | — | — | — | 1 | 1 |
| Cerebellar ataxia | D002524 | — | — | — | — | — | — | 1 | 1 |
| Ototoxicity | D000081015 | — | — | — | — | — | — | 1 | 1 |
Show 28 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Vincristine |
| INN | vincristine |
| Description | Vincristine is a vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer. It has a role as a tubulin modulator, a microtubule-destabilising agent, a plant metabolite, an antineoplastic agent and a drug. It is a methyl ester, an acetate ester, a tertiary alcohol, a member of formamides, an organic heteropentacyclic compound, an organic heterotetracyclic compound, a tertiary amino compound and a vinca alkaloid. It is a conjugate base of a vincristine(2+). It derives from a hydride of a vincaleukoblastine. |
| Classification | Small molecule |
| Drug class | vinca alkaloids |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC[C@]1(O)C[C@H]2CN(CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C=O)[C@H]3[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]5(CC)C=CCN6CC[C@]43[C@@H]65)C2)C1 |
Identifiers
| PDB | — |
| CAS-ID | 57-22-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL90555 |
| ChEBI ID | 28445 |
| PubChem CID | 5978 |
| DrugBank | DB00541 |
| UNII ID | 5J49Q6B70F (ChemIDplus, GSRS) |
Target
Agency Approved
TUBB
TUBB
Organism
Homo sapiens
Gene name
TUBB
Gene synonyms
TUBB5
NCBI Gene ID
Protein name
tubulin beta chain
Protein synonyms
beta Ib tubulin, epididymis secretory sperm binding protein, tubulin beta-1 chain, Tubulin beta-5 chain, tubulin, beta polypeptide
Uniprot ID
Mouse ortholog
Tubb5 (22154)
tubulin beta-5 chain (Q3UF52)
Alternate
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Variants
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Marqibo – Spectrum Pharmaceuticals
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Estimated US medical usage
Vincristine
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Trends
PubMed Central
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Additional graphs summarizing 66,395 documents
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Safety
Black-box Warning
Black-box warning for: Vincristine sulfate
Adverse Events
Top Adverse Reactions
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88,611 adverse events reported
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