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AboutPricing
Drug ReportsVincristine
Vincristine
Vincristine (vincristine) is a small molecule pharmaceutical. Vincristine was first approved as Oncovin on 1982-01-01. It is used to treat hodgkin disease, leukemia, neuroblastoma, non-hodgkin lymphoma, and rhabdomyosarcoma amongst others in the USA. The pharmaceutical is active against tubulin beta chain.
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EMA approval date
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Study first post date
Last update post date
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Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
urogenital diseasesD000091642
hemic and lymphatic diseasesD006425
hereditary congenital and neonatal diseases and abnormalitiesD009358
immune system diseasesD007154
Trade Name
FDA
EMA
Vincristine (discontinued: Marqibo, Oncovin, Vincasar, Vincrex, Vincristine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Vincristine sulfate
Tradename
Company
Number
Date
Products
MARQIBO KITAcrotech BiopharmaN-202497 DISCN2012-08-09
1 products, RLD
ONCOVINEli LillyN-014103 DISCN1982-01-01
3 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
vincristine sulfateANDA2024-04-24
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
leukemia—D007938C95
non-hodgkin lymphoma—D008228C85.9
neuroblastomaEFO_0000621D009447—
hodgkin disease—D006689C81
rhabdomyosarcoma—D012208—
wilms tumorEFO_0000212D009396—
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
L: Antineoplastic and immunomodulating agents
— L01: Antineoplastic agents
— L01C: Plant alkaloids and other natural products, antineoplastic drugs
— L01CA: Vinca alkaloids and analogues, antineoplastic
— L01CA02: Vincristine
HCPCS
Code
Description
J9370
Vincristine sulfate, 1 mg
J9371
Injection, vincristine sulfate liposome, 1 mg
Clinical
Clinical Trials
1382 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Non-hodgkin lymphomaD008228—C85.9——1——1
LymphomaD008223—C85.9——1——1
Mantle-cell lymphomaD020522—C83.1——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369—C80—1———1
Hodgkin diseaseD006689—C81—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameVincristine
INNvincristine
Description
Vincristine is a vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer. It has a role as a tubulin modulator, a microtubule-destabilising agent, a plant metabolite, an antineoplastic agent and a drug. It is a methyl ester, an acetate ester, a tertiary alcohol, a member of formamides, an organic heteropentacyclic compound, an organic heterotetracyclic compound, a tertiary amino compound and a vinca alkaloid. It is a conjugate base of a vincristine(2+). It derives from a hydride of a vincaleukoblastine.
Classification
Small molecule
Drug classvinca alkaloids
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CC[C@]1(O)C[C@H]2CN(CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C=O)[C@H]3[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]5(CC)C=CCN6CC[C@]43[C@@H]65)C2)C1
Identifiers
PDB—
CAS-ID57-22-7
RxCUI—
ChEMBL IDCHEMBL90555
ChEBI ID28445
PubChem CID5978
DrugBankDB00541
UNII ID5J49Q6B70F (ChemIDplus, GSRS)
Target
Agency Approved
TUBB
TUBB
Organism
Homo sapiens
Gene name
TUBB
Gene synonyms
TUBB5
NCBI Gene ID
203068
Protein name
tubulin beta chain
Protein synonyms
beta Ib tubulin, epididymis secretory sperm binding protein, tubulin beta-1 chain, Tubulin beta-5 chain, tubulin, beta polypeptide
Uniprot ID
Q9CY33
Mouse ortholog
Tubb5 (22154)
tubulin beta-5 chain (Q3UF52)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Marqibo – Spectrum Pharmaceuticals
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Estimated US medical usage
Vincristine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 69,643 documents
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Safety
Black-box Warning
Black-box warning for: Vincristine sulfate
Adverse Events
Top Adverse Reactions
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91,873 adverse events reported
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