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Drug ReportsVildagliptin
Vildagliptin
Eucreas, Galvus, Icandra, Jalra, Vildagliptin / Metformin, Xiliarx, Zomarist (vildagliptin) is a small molecule pharmaceutical. Vildagliptin was first approved as Galvus on 2007-09-25. It has been approved in Europe to treat type 2 diabetes mellitus. The pharmaceutical is active against dipeptidyl peptidase 4.
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Events Timeline
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nutritional and metabolic diseasesD009750
endocrine system diseasesD004700
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
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Brand Name
Status
Last Update
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A10: Drugs used in diabetes
— A10B: Blood glucose lowering drugs, excl. insulins
— A10BD: Combinations of oral blood glucose lowering drugs
— A10BD08: Metformin and vildagliptin
— A10BH: Dipeptidyl peptidase 4 (dpp-4) inhibitors for blood glucose lowering
— A10BH02: Vildagliptin
HCPCS
No data
Clinical
Clinical Trials
210 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Type 2 diabetes mellitusD003924EFO_0001360E11356624—95
Diabetes mellitusD003920EFO_0000400E08-E13255514—74
Insulin resistanceD007333EFO_0002614E88.819——21—3
HypoglycemiaD007003—E16.2———2—2
HypertensionD006973EFO_0000537I10———1—1
Patient preferenceD057240—————1—1
Heart failureD006333EFO_0003144I50———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Renal insufficiencyD051437—N19114——5
Healthy volunteers/patients———2—1——3
Prediabetic stateD011236EFO_1001121R73.03——2——2
Glucose intoleranceD018149HP_0000833R73.03——2——2
HyperglycemiaD006943—R73.9——2——2
Type 1 diabetes mellitusD003922EFO_0001359E10——1——1
HypersensitivityD006967EFO_0003785T78.40——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Breast neoplasmsD001943EFO_0003869C50—1———1
Indications Phases 1
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Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Pancreatic neoplasmsD010190EFO_0003860C25————11
NeoplasmsD009369—C80————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameVildagliptin
INNvildagliptin
Description
Vildagliptin is an amino acid amide.
Classification
Small molecule
Drug classdipeptidyl aminopeptidase-IV inhibitors
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Structure (InChI/SMILES or Protein Sequence)
N#C[C@@H]1CCCN1C(=O)CNC12CC3CC(CC(O)(C3)C1)C2
Identifiers
PDB—
CAS-ID274901-16-5
RxCUI—
ChEMBL IDCHEMBL142703
ChEBI ID—
PubChem CID6918537
DrugBankDB04876
UNII IDI6B4B2U96P (ChemIDplus, GSRS)
Target
Agency Approved
DPP4
DPP4
Organism
Homo sapiens
Gene name
DPP4
Gene synonyms
ADCP2, CD26
NCBI Gene ID
1803
Protein name
dipeptidyl peptidase 4
Protein synonyms
ADABP, ADCP-2, Adenosine deaminase complexing protein 2, CD26, Dipeptidyl peptidase IV, dipeptidylpeptidase 4, dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2), DPP IV, Gly-Pro naphthylamidase, Post-proline dipeptidyl aminopeptidase IV, T-cell activation antigen CD26, TP103, Xaa-Pro-dipeptidylaminopeptidase
Uniprot ID
Q53TN1
Mouse ortholog
Dpp4 (13482)
dipeptidyl peptidase 4 (Q3U514)
Alternate
No data
Variants
No data
Financial
Revenue by drug
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Galvus – Novartis
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Estimated US medical usage
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 6,885 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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12,845 adverse events reported
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