Vildagliptin
Eucreas, Galvus, Icandra, Jalra, Vildagliptin / Metformin, Xiliarx, Zomarist (vildagliptin) is a small molecule pharmaceutical. Vildagliptin was first approved as Galvus on 2007-09-25. It has been approved in Europe to treat type 2 diabetes mellitus. The pharmaceutical is active against dipeptidyl peptidase 4.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| nutritional and metabolic diseases | D009750 |
| endocrine system diseases | D004700 |
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| anorectal | OTC monograph final | 2017-12-29 |
| avobenzone, homosalate, octisalate, octocrylene, oxybenzone | OTC monograph not final | 2019-06-26 |
| chocolate laxative | C200263 | 2024-12-23 |
| daytime nighttime childrens multi-symptom cold | C200263 | 2024-11-26 |
| discount drug mart eye drops advanced relief | OTC monograph final | 2023-03-20 |
| each relief | OTC monograph not final | 2017-01-20 |
| ear wax removal drops | C200263 | 2023-12-04 |
| earwax removal drops | OTC monograph final | 2017-12-29 |
| eqaute-sunscreen sport spf 100 | OTC monograph not final | 2019-02-13 |
| equagesic | 2008-01-15 |
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Indications
FDA
EMA
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Agency Specific
FDA
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Patent Expiration
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ATC Codes
A: Alimentary tract and metabolism drugs
— A10: Drugs used in diabetes
— A10B: Blood glucose lowering drugs, excl. insulins
— A10BD: Combinations of oral blood glucose lowering drugs
— A10BD08: Metformin and vildagliptin
— A10BH: Dipeptidyl peptidase 4 (dpp-4) inhibitors for blood glucose lowering
— A10BH02: Vildagliptin
HCPCS
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Clinical
Clinical Trials
208 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 6 | 8 | 76 | 55 | 22 | 162 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | 4 | 12 | 69 | 40 | 11 | 131 |
| Renal insufficiency | D051437 | — | N19 | 1 | 1 | 4 | 1 | — | 6 |
| Heart failure | D006333 | EFO_0003144 | I50 | — | — | — | 2 | 3 | 5 |
| Coronary artery disease | D003324 | — | I25.1 | — | — | — | 3 | 1 | 4 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | — | — | 3 | 1 | 4 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | 1 | 1 | 2 | — | 4 |
| Hypoglycemia | D007003 | — | E16.2 | — | — | — | 3 | — | 3 |
| Insulin resistance | D007333 | EFO_0002614 | E88.819 | — | — | 2 | 1 | — | 3 |
| Coronary disease | D003327 | — | — | — | — | — | 2 | 1 | 3 |
Show 21 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 5 | — | 1 | — | 1 | 7 |
| Prediabetic state | D011236 | EFO_1001121 | R73.03 | — | 1 | 2 | — | — | 3 |
| Glucose intolerance | D018149 | HP_0000833 | R73.03 | — | 1 | 2 | — | — | 3 |
| Hyperglycemia | D006943 | — | R73.9 | — | — | 2 | — | — | 2 |
| Retinal neovascularization | D015861 | — | H35.05 | — | 1 | 1 | — | — | 1 |
| Pathologic neovascularization | D009389 | — | — | — | 1 | 1 | — | — | 1 |
| Peripheral nervous system diseases | D010523 | — | G64 | — | — | 1 | — | — | 1 |
| Diabetic neuropathies | D003929 | EFO_1000783 | — | — | — | 1 | — | — | 1 |
| Polycystic ovary syndrome | D011085 | EFO_0000660 | E28.2 | — | 1 | 1 | — | — | 1 |
| Ovarian cysts | D010048 | — | N83.1 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | — | — | — | 1 |
| Depression | D003863 | — | F33.9 | 1 | 1 | — | — | — | 1 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | 1 | 1 | — | — | — | 1 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | 1 | 1 | — | — | — | 1 |
| Dyslipidemias | D050171 | — | — | — | 1 | — | — | — | 1 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | 1 | — | — | — | 1 |
| Kidney transplantation | D016030 | — | — | — | 1 | — | — | — | 1 |
| Gestational diabetes | D016640 | — | O24.4 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | 1 | — | — | — | 2 | 3 |
| Disease | D004194 | EFO_0000408 | R69 | 1 | — | — | — | 2 | 3 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | — | — | — | 2 | 2 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | — | — | — | 2 | 2 |
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | — | — | — | — | 2 | 2 |
| Fatty liver | D005234 | EFO_0003934 | — | — | — | — | — | 2 | 2 |
| Therapeutic equivalency | D013810 | — | — | — | — | — | — | 2 | 2 |
| Sepsis | D018805 | EFO_0001420 | A41.9 | — | — | — | — | 1 | 1 |
| Ketosis | D007662 | — | R82.4 | — | — | — | — | 1 | 1 |
| Diabetic ketoacidosis | D016883 | EFO_1000897 | — | — | — | — | — | 1 | 1 |
| Ischemic stroke | D000083242 | — | — | — | — | — | — | 1 | 1 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Vildagliptin |
| INN | vildagliptin |
| Description | Vildagliptin is an amino acid amide. |
| Classification | Small molecule |
| Drug class | dipeptidyl aminopeptidase-IV inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | N#C[C@@H]1CCCN1C(=O)CNC12CC3CC(CC(O)(C3)C1)C2 |
Identifiers
| PDB | — |
| CAS-ID | 274901-16-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL142703 |
| ChEBI ID | — |
| PubChem CID | 6918537 |
| DrugBank | DB04876 |
| UNII ID | I6B4B2U96P (ChemIDplus, GSRS) |
Target
Agency Approved
DPP4
DPP4
Organism
Homo sapiens
Gene name
DPP4
Gene synonyms
ADCP2, CD26
NCBI Gene ID
Protein name
dipeptidyl peptidase 4
Protein synonyms
ADABP, ADCP-2, Adenosine deaminase complexing protein 2, CD26, Dipeptidyl peptidase IV, dipeptidylpeptidase 4, dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2), DPP IV, Gly-Pro naphthylamidase, Post-proline dipeptidyl aminopeptidase IV, T-cell activation antigen CD26, TP103, Xaa-Pro-dipeptidylaminopeptidase
Uniprot ID
Mouse ortholog
Dpp4 (13482)
dipeptidyl peptidase 4 (Q3U514)
Alternate
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Variants
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Financial
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Galvus – Novartis
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Trends
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Safety
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Adverse Events
Top Adverse Reactions
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5,807 adverse events reported
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