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Drug ReportsVigabatrin
Sabril, Kigabeq(vigabatrin)
Kigabeq, Sabril, Vigabatrin, Vigadrone, Vigafyde, Vigpoder (vigabatrin) is a small molecule pharmaceutical. Vigabatrin was first approved as Sabril on 2009-08-21. It is used to treat complex partial epilepsy, epilepsy, and infantile spasms in the USA. It has been approved in Europe to treat infantile spasms and partial epilepsies. The pharmaceutical is active against 4-aminobutyrate aminotransferase, mitochondrial. In addition, it is known to target vesicular inhibitory amino acid transporter.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
Trade Name
FDA
EMA
Sabril, Vigabatrin, Vigadrone, Vigafyde, Vigpoder (discontinued: Vigabatrin)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Vigabatrin
Tradename
Company
Number
Date
Products
SABRILLundbeckN-020427 RX2009-08-21
1 products, RLD, RS
SABRILLundbeckN-022006 RX2009-08-21
1 products, RLD, RS
VIGAFYDEPyros PharmaceuticalsN-217684 RX2024-06-17
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
sabrilNew Drug Application2024-01-09
vigabatrinANDA2024-09-30
vigabatrin for oral solutionANDA2024-04-22
vigadroneANDA2024-11-18
vigafydeNew Drug Application2025-02-27
vigpoderANDA2024-12-13
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N03: Antiepileptics
— N03A: Antiepileptics
— N03AG: Fatty acid derivatives, antiepileptics
— N03AG04: Vigabatrin
HCPCS
No data
Clinical
Clinical Trials
33 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SeizuresD012640—G40.4———213
SpasmD013035—M62.83———112
Infantile spasmsD013036EFO_1000643G40.82———112
Tuberous sclerosisD014402—Q85.1———1—1
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameVigabatrin
INNvigabatrin
Description
Vigabatrin is a gamma-amino acid having a gamma-vinyl GABA structure. It is an irreversible inhibitor of gamma-aminobutyric 664 acid transaminase It has a role as an anticonvulsant and an EC 2.6.1.19 (4-aminobutyrate--2-oxoglutarate transaminase) inhibitor.
Classification
Small molecule
Drug classgabamimetics
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
C=CC(N)CCC(=O)O
Identifiers
PDB—
CAS-ID60643-86-9
RxCUI—
ChEMBL IDCHEMBL89598
ChEBI ID63638
PubChem CID5665
DrugBankDB01080
UNII IDGR120KRT6K (ChemIDplus, GSRS)
Target
Agency Approved
ABAT
ABAT
Organism
Homo sapiens
Gene name
ABAT
Gene synonyms
GABAT
NCBI Gene ID
Protein name
4-aminobutyrate aminotransferase, mitochondrial
Protein synonyms
(S)-3-amino-2-methylpropionate transaminase, 4-aminobutyrate transaminase, GABA aminotransferase, GABA transaminase, GABA transferase, GABA-AT, GABA-T, Gamma-amino-N-butyrate transaminase, gamma-aminobutyrate aminotransferase, L-AIBAT
Uniprot ID
Mouse ortholog
Abat (268860)
4-aminobutyrate aminotransferase, mitochondrial (Q8BZA3)
Alternate
SLC32A1
SLC32A1
Organism
Homo sapiens
Gene name
SLC32A1
Gene synonyms
VGAT, VIAAT
NCBI Gene ID
Protein name
vesicular inhibitory amino acid transporter
Protein synonyms
GABA and glycine transporter, hVIAAT, solute carrier family 32 (GABA vesicular transporter), member 1, Solute carrier family 32 member 1, Vesicular GABA transporter
Uniprot ID
Mouse ortholog
Slc32a1 (22348)
vesicular inhibitory amino acid transporter (O35633)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 5,075 documents
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Safety
Black-box Warning
Black-box warning for: Sabril, Vigabatrin, Vigabatrin for oral solution, Vigadrone, Vigafyde, Vigpoder
Adverse Events
Top Adverse Reactions
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14,141 adverse events reported
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