Sabril, Kigabeq(vigabatrin)
Kigabeq, Sabril, Vigabatrin, Vigadrone, Vigafyde, Vigpoder (vigabatrin) is a small molecule pharmaceutical. Vigabatrin was first approved as Sabril on 2009-08-21. It is used to treat complex partial epilepsy, epilepsy, and infantile spasms in the USA. It has been approved in Europe to treat infantile spasms and partial epilepsies. The pharmaceutical is active against 4-aminobutyrate aminotransferase, mitochondrial. In addition, it is known to target vesicular inhibitory amino acid transporter.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| nervous system diseases | D009422 |
Trade Name
FDA
EMA
Sabril, Vigabatrin, Vigadrone, Vigafyde, Vigpoder (discontinued: Vigabatrin)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| sabril | New Drug Application | 2025-09-30 |
| vigabatrin | ANDA | 2025-11-07 |
| vigabatrin for oral solution | ANDA | 2024-04-22 |
| vigadrone | ANDA | 2025-07-24 |
| vigafyde | New Drug Application | 2025-09-23 |
| vigpoder | ANDA | 2024-12-13 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| epilepsy | EFO_0000474 | D004827 | G40.9 |
| infantile spasms | EFO_1000643 | D013036 | G40.82 |
| complex partial epilepsy | EFO_1000877 | D017029 | — |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
33 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Epilepsy | D004827 | EFO_0000474 | G40.9 | — | 1 | 1 | 3 | 5 | 9 |
| Infantile spasms | D013036 | EFO_1000643 | G40.82 | — | — | 4 | 1 | 3 | 8 |
| Seizures | D012640 | — | G40.4 | — | — | 1 | 2 | 1 | 4 |
| Tuberous sclerosis | D014402 | — | Q85.1 | — | 2 | 1 | 1 | — | 3 |
| Drug resistant epilepsy | D000069279 | — | — | — | — | — | 1 | 1 | 2 |
| Central nervous system diseases | D002493 | — | G96.9 | — | — | 1 | 1 | — | 2 |
| Intellectual disability | D008607 | EFO_0003847 | F73 | — | — | — | 1 | — | 1 |
| Neurologic manifestations | D009461 | — | — | — | — | — | 1 | — | 1 |
| Brain diseases | D001927 | — | G93.40 | — | — | — | 1 | — | 1 |
| Nervous system diseases | D009422 | — | G00-G99 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cocaine-related disorders | D019970 | — | F14 | 1 | 5 | 1 | — | — | 6 |
| Spasm | D013035 | — | M62.83 | — | — | 1 | — | 1 | 2 |
| Neoplasms | D009369 | — | C80 | — | 1 | 1 | — | — | 1 |
| Epileptic syndromes | D000073376 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Addictive behavior | D016739 | EFO_0004347 | — | 2 | 3 | — | — | — | 5 |
| Status epilepticus | D013226 | EFO_0008526 | G41 | — | 1 | — | — | 1 | 2 |
| Insulin resistance | D007333 | EFO_0002614 | E88.819 | — | 2 | — | — | — | 2 |
| Coma | D003128 | — | R40.2 | — | 1 | — | — | — | 1 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | 1 | — | — | — | 1 |
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | — | 1 | — | — | — | 1 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | 1 | — | — | — | 1 |
| Glucose intolerance | D018149 | HP_0000833 | R73.03 | — | 1 | — | — | — | 1 |
| Hyperinsulinism | D006946 | — | E16.1 | — | 1 | — | — | — | 1 |
| Tourette syndrome | D005879 | EFO_0004895 | F95.2 | 1 | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Therapeutic equivalency | D013810 | — | — | 1 | — | — | — | — | 1 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | 1 | — | — | — | — | 1 |
| Mental disorders | D001523 | EFO_0000677 | F91.9 | 1 | — | — | — | — | 1 |
| Amphetamine-related disorders | D019969 | EFO_0004701 | F15 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Complex partial epilepsy | D017029 | EFO_1000877 | — | — | — | — | — | 2 | 2 |
| Financial stress | D000086522 | — | — | — | — | — | — | 1 | 1 |
| Autoimmune diseases of the nervous system | D020274 | — | — | — | — | — | — | 1 | 1 |
| Muscle cramp | D009120 | — | — | — | — | — | — | 1 | 1 |
| Partial epilepsies | D004828 | EFO_0004263 | — | — | — | — | — | 1 | 1 |
| Heart arrest | D006323 | EFO_0009492 | I46 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Vigabatrin |
| INN | vigabatrin |
| Description | Vigabatrin is a gamma-amino acid having a gamma-vinyl GABA structure. It is an irreversible inhibitor of gamma-aminobutyric 664 acid transaminase It has a role as an anticonvulsant and an EC 2.6.1.19 (4-aminobutyrate--2-oxoglutarate transaminase) inhibitor. |
| Classification | Small molecule |
| Drug class | gabamimetics |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C=CC(N)CCC(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 60643-86-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL89598 |
| ChEBI ID | 63638 |
| PubChem CID | 5665 |
| DrugBank | DB01080 |
| UNII ID | GR120KRT6K (ChemIDplus, GSRS) |
Target
Agency Approved
ABAT
ABAT
Organism
Homo sapiens
Gene name
ABAT
Gene synonyms
GABAT
NCBI Gene ID
Protein name
4-aminobutyrate aminotransferase, mitochondrial
Protein synonyms
(S)-3-amino-2-methylpropionate transaminase, 4-aminobutyrate transaminase, GABA aminotransferase, GABA transaminase, GABA transferase, GABA-AT, GABA-T, Gamma-amino-N-butyrate transaminase, gamma-aminobutyrate aminotransferase, L-AIBAT
Uniprot ID
Mouse ortholog
Abat (268860)
4-aminobutyrate aminotransferase, mitochondrial (Q8BZA3)
Alternate
SLC32A1
SLC32A1
Organism
Homo sapiens
Gene name
SLC32A1
Gene synonyms
VGAT, VIAAT
NCBI Gene ID
Protein name
vesicular inhibitory amino acid transporter
Protein synonyms
GABA and glycine transporter, hVIAAT, solute carrier family 32 (GABA vesicular transporter), member 1, Solute carrier family 32 member 1, Vesicular GABA transporter
Uniprot ID
Mouse ortholog
Slc32a1 (22348)
vesicular inhibitory amino acid transporter (O35633)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
Black-box warning for: Sabril, Vigabatrin, Vigabatrin for oral solution, Vigadrone, Vigafyde, Vigpoder
Adverse Events
Top Adverse Reactions
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14,820 adverse events reported
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