Vidarabine
Vira-a (vidarabine) is a small molecule pharmaceutical. Vidarabine was first approved as Vira-a on 1982-01-01. It is used to treat chickenpox, herpes simplex, herpes zoster, herpetic keratitis, and infectious keratoconjunctivitis in the USA. The pharmaceutical is active against adenosine deaminase.
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Vidarabine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| VIRA-A | Parkedale Pharmaceuticals | N-050486 DISCN | 1982-01-01 | 1 products |
| VIRA-A | Parkedale Pharmaceuticals | N-050523 DISCN | 1982-01-01 | 1 products |
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ATC Codes
J: Antiinfectives for systemic use
— J05: Antivirals for systemic use
— J05A: Direct acting antivirals
— J05AB: Nucleosides and nucleotides excl. reverse transcriptase inhibitors
— J05AB03: Vidarabine
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01A: Antiinfective ophthalmologics
— S01AD: Antivirals, ophthalmologic
— S01AD06: Vidarabine
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Clinical
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5645 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatitis | D006505 | HP_0012115 | K75.9 | 149 | 298 | 178 | 113 | 208 | 891 |
| Hepatitis a | D006506 | EFO_0007305 | B15 | 116 | 263 | 155 | 99 | 165 | 750 |
| Hepatitis c | D006526 | — | B19.2 | 97 | 201 | 134 | 65 | 138 | 597 |
| Infections | D007239 | EFO_0000544 | — | 129 | 174 | 116 | 30 | 184 | 591 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 157 | 145 | 102 | 51 | 155 | 586 |
| Human influenza | D007251 | EFO_0007328 | J11.1 | 139 | 179 | 120 | 72 | 96 | 565 |
| Leukemia | D007938 | — | C95 | 190 | 270 | 84 | 4 | 24 | 491 |
| Covid-19 | D000086382 | — | — | 54 | 103 | 73 | 30 | 185 | 411 |
| Virus diseases | D014777 | — | B34 | 118 | 128 | 66 | 18 | 107 | 410 |
| Communicable diseases | D003141 | — | — | 75 | 106 | 75 | 19 | 121 | 370 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | — | 66 | 94 | 31 | — | 11 | 179 |
| Myelodysplastic syndromes | D009190 | — | D46 | 66 | 106 | 14 | — | 10 | 165 |
| Lymphoid leukemia | D007945 | — | C91 | 54 | 77 | 30 | — | 9 | 149 |
| Preleukemia | D011289 | — | — | 52 | 82 | 8 | — | 7 | 124 |
| Dengue | D003715 | — | A90 | 44 | 27 | 9 | — | 11 | 89 |
| Hodgkin disease | D006689 | — | C81 | 26 | 42 | 6 | — | 10 | 71 |
| Respiratory syncytial viruses | D012136 | — | — | 23 | 23 | 12 | — | 17 | 70 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 18 | 45 | 6 | — | 6 | 69 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 23 | 41 | 9 | — | 6 | 68 |
| Melanoma | D008545 | — | — | 37 | 30 | 3 | — | 2 | 61 |
Show 186 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 31 | 9 | — | — | 4 | 39 |
| T-cell lymphoma | D016399 | — | — | 12 | 24 | — | — | 5 | 35 |
| Zika virus infection | D000071243 | — | A92.5 | 15 | 2 | — | — | 11 | 28 |
| Adenoviridae infections | D000257 | EFO_1001259 | B34.0 | 19 | 10 | — | — | 5 | 27 |
| B-cell lymphoma marginal zone | D018442 | — | C88.4 | 10 | 16 | — | — | 4 | 26 |
| T-cell lymphoma peripheral | D016411 | — | — | 9 | 16 | — | — | 3 | 25 |
| Prostatic neoplasms | D011471 | — | C61 | 11 | 15 | — | — | 1 | 24 |
| Oropharyngeal neoplasms | D009959 | — | — | 7 | 12 | — | — | 7 | 23 |
| Glioma | D005910 | EFO_0000520 | — | 16 | 8 | — | — | 2 | 22 |
| Glioblastoma | D005909 | EFO_0000515 | — | 19 | 8 | — | — | — | 22 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Dermatitis | D003872 | HP_0011123 | L30.9 | 1 | — | — | — | 7 | 8 |
| Hypersensitivity | D006967 | HP_0012393 | T78.40 | 5 | — | — | — | 2 | 7 |
| Varicella zoster virus infection | D000073618 | — | — | 2 | — | — | — | 5 | 7 |
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | 1 | — | — | — | 6 | 7 |
| Oligodendroglioma | D009837 | EFO_0000631 | — | 5 | — | — | — | 1 | 6 |
| Adenoviridae | D000256 | — | — | 2 | — | — | — | 3 | 5 |
| Emergencies | D004630 | — | — | 2 | — | — | — | 3 | 5 |
| Medulloblastoma | D008527 | — | — | 4 | — | — | — | — | 4 |
| Hiv seronegativity | D018023 | — | — | 4 | — | — | — | — | 4 |
| Eczema | D004485 | HP_0000964 | L30.9 | 1 | — | — | — | 3 | 4 |
Show 112 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sepsis | D018805 | HP_0100806 | A41.9 | — | — | — | — | 8 | 8 |
| Mental disorders | D001523 | EFO_0000677 | F91.9 | — | — | — | — | 8 | 8 |
| Anxiety | D001007 | EFO_0005230 | F41.1 | — | — | — | — | 7 | 7 |
| Toxemia | D014115 | — | — | — | — | — | — | 5 | 5 |
| Coronary artery disease | D003324 | — | I25.1 | — | — | — | — | 5 | 5 |
| Recreational drug use | D000084783 | — | — | — | — | — | — | 5 | 5 |
| Rhinovirus | D012229 | — | — | — | — | — | — | 5 | 5 |
| Critical illness | D016638 | — | — | — | — | — | — | 5 | 5 |
| Drug misuse | D000076064 | — | — | — | — | — | — | 4 | 4 |
| Sleep initiation and maintenance disorders | D007319 | — | F51.01 | — | — | — | — | 4 | 4 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Vidarabine |
| INN | vidarabine |
| Description | Adenine arabinoside is a purine nucleoside in which adenine is attached to arabinofuranose via a beta-N(9)-glycosidic bond. It has a role as an antineoplastic agent, a bacterial metabolite and a nucleoside antibiotic. It is a purine nucleoside and a beta-D-arabinoside. It is functionally related to an adenine. |
| Classification | Small molecule |
| Drug class | antineoplastics (arabinofuranosyl derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O |
Identifiers
| PDB | — |
| CAS-ID | 5536-17-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1090 |
| ChEBI ID | 45327 |
| PubChem CID | 21704 |
| DrugBank | DB00194 |
| UNII ID | 3XQD2MEW34 (ChemIDplus, GSRS) |
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Vidarabine
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Safety
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1,008 adverse events reported
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