Vicriviroc
Vicriviroc is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target C-C chemokine receptor type 5.
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Commercial
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Clinical
Clinical Trials
131 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Glioblastoma | D005909 | EFO_0000515 | — | 23 | 23 | 7 | 1 | — | 43 |
| Glioma | D005910 | EFO_0000520 | — | 9 | 10 | 1 | 1 | — | 17 |
| Astrocytoma | D001254 | EFO_0000271 | — | 5 | 7 | 2 | 1 | — | 12 |
| Oligodendroglioma | D009837 | EFO_0000631 | — | 2 | 3 | 1 | 1 | — | 6 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Gliosarcoma | D018316 | — | — | 16 | 15 | 4 | — | — | 26 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 4 | 6 | 3 | — | 1 | 13 |
| Lung neoplasms | D008175 | — | C34.90 | 5 | 9 | 2 | — | 1 | 13 |
| Neoplasms | D009369 | — | C80 | 6 | 6 | 1 | — | — | 10 |
| Melanoma | D008545 | — | — | 4 | 7 | 1 | — | — | 10 |
| Non-small-cell lung carcinoma | D002289 | — | — | 4 | 5 | 2 | — | 1 | 9 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 3 | 3 | 1 | — | — | 5 |
| Neuroendocrine tumors | D018358 | EFO_1001901 | D3A.8 | — | 3 | 1 | — | — | 4 |
| Neuroblastoma | D009447 | EFO_0000621 | — | — | 3 | 1 | — | — | 4 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | — | 1 | 3 | — | — | 4 |
Show 15 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Small cell lung carcinoma | D055752 | — | — | 1 | 5 | — | — | — | 5 |
| Recurrence | D012008 | — | — | 2 | 5 | — | — | — | 5 |
| Central nervous system neoplasms | D016543 | — | — | 3 | 3 | — | — | — | 5 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 3 | 1 | — | — | — | 4 |
| Carcinoma | D002277 | — | C80.0 | 2 | 3 | — | — | — | 4 |
| Myelodysplastic syndromes | D009190 | — | D46 | 2 | 1 | — | — | — | 3 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 2 | 1 | — | — | — | 3 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 3 | 1 | — | — | — | 3 |
| Hodgkin disease | D006689 | — | C81 | 2 | 1 | — | — | — | 3 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 3 | 1 | — | — | — | 3 |
Show 39 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 2 | — | — | — | — | 2 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 2 | — | — | — | — | 2 |
| Myelomonocytic leukemia chronic | D015477 | — | C93.1 | 2 | — | — | — | — | 2 |
| Hematologic neoplasms | D019337 | — | — | 1 | — | — | — | — | 1 |
| Castration-resistant prostatic neoplasms | D064129 | — | — | 1 | — | — | — | — | 1 |
| Myeloproliferative disorders | D009196 | — | D47.1 | 1 | — | — | — | — | 1 |
| Primary myelofibrosis | D055728 | — | D47.4 | 1 | — | — | — | — | 1 |
| Multiple myeloma | D009101 | — | C90.0 | 1 | — | — | — | — | 1 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 1 | — | — | — | — | 1 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 1 | — | — | — | — | 1 |
Show 31 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pelvic organ prolapse | D056887 | EFO_0004710 | — | — | — | — | — | 1 | 1 |
| Prolapse | D011391 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Vicriviroc |
| INN | vicriviroc |
| Description | (4,6-dimethyl-5-pyrimidinyl)-[4-[(3S)-4-[(1R)-2-methoxy-1-[4-(trifluoromethyl)phenyl]ethyl]-3-methyl-1-piperazinyl]-4-methyl-1-piperidinyl]methanone is a member of (trifluoromethyl)benzenes. |
| Classification | Small molecule |
| Drug class | antivirals; antivirals, chemokine receptor (CCR) antagonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COC[C@@H](c1ccc(C(F)(F)F)cc1)N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C |
Identifiers
| PDB | — |
| CAS-ID | 306296-47-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL82301 |
| ChEBI ID | — |
| PubChem CID | 3009355 |
| DrugBank | — |
| UNII ID | TL515DW4QS (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
CCR5
CCR5
Organism
Homo sapiens
Gene name
CCR5
Gene synonyms
CMKBR5
NCBI Gene ID
Protein name
C-C chemokine receptor type 5
Protein synonyms
C-C motif chemokine receptor 5 A159A, CD195, chemokine (C-C motif) receptor 5, chemokine receptor CCR5, chemokine recptor CCR5 Delta32, CHEMR13, HIV-1 fusion coreceptor, mutant C-C motif chemokine receptor
Uniprot ID
Mouse ortholog
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—
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 763 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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13 adverse events reported
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