Visudyne(verteporfin)
Visudyne (verteporfin) is a small molecule pharmaceutical. Verteporfin was first approved as Visudyne on 2000-04-12. It is used to treat choroidal neovascularization in the USA. It has been approved in Europe to treat degenerative myopia and macular degeneration.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| eye diseases | D005128 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Visudyne
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Verteporfin
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| VISUDYNE | Bausch Health Companies | N-021119 RX | 2000-04-12 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| visudyne | New Drug Application | 2023-02-24 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| choroidal neovascularization | — | D020256 | — |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J3396 | Injection, verteporfin, 0.1 mg |
Clinical
Clinical Trials
104 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | 5 | 22 | 14 | 10 | 5 | 51 |
| Choroidal neovascularization | D020256 | — | — | 3 | 8 | 8 | 3 | 4 | 22 |
| Pathologic neovascularization | D009389 | — | — | 3 | 8 | 8 | 2 | 5 | 22 |
| Central serous chorioretinopathy | D056833 | — | H35.71 | 1 | 2 | — | 3 | 10 | 15 |
| Vascular diseases | D014652 | EFO_0004264 | I77 | 1 | 1 | — | 7 | 6 | 14 |
| Polypoidal choroidal vasculopathy | D000092342 | — | — | 1 | 1 | — | 7 | 4 | 12 |
| Wet macular degeneration | D057135 | EFO_0004683 | — | 1 | 1 | 1 | 2 | 2 | 7 |
| Retinal detachment | D012163 | EFO_0005773 | H33.2 | — | — | — | 1 | 1 | 2 |
| Dissociative disorders | D004213 | — | F44.1 | — | — | — | 1 | 1 | 2 |
| Disease progression | D018450 | — | — | — | — | — | 1 | 1 | 2 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myopia | D009216 | EFO_0003927 | H52.1 | 2 | — | 3 | — | 1 | 6 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 1 | — | 1 | — | — | 2 |
| Vision disorders | D014786 | HP_0000505 | H53.11 | — | — | 2 | — | — | 2 |
| Retinal neovascularization | D015861 | — | — | — | 1 | 2 | — | — | 2 |
| Low vision | D015354 | — | — | — | — | 2 | — | — | 2 |
| Degenerative myopia | D047728 | — | H44.2 | 1 | — | 1 | — | — | 2 |
| Carcinoma | D002277 | — | C80.0 | — | 1 | 1 | — | — | 2 |
| Basal cell carcinoma | D002280 | — | — | — | — | 1 | — | — | 1 |
| Syndrome | D013577 | — | — | — | — | 1 | — | — | 1 |
| Basal cell nevus syndrome | D001478 | EFO_0004136 | — | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Histoplasmosis | D006660 | EFO_0007310 | B39 | — | 1 | — | — | 2 | 3 |
| Macular edema | D008269 | — | — | — | 1 | — | — | 1 | 2 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | 2 | — | — | — | 2 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | — | — | 1 | 2 |
| Recurrence | D012008 | — | — | 1 | 1 | — | — | — | 1 |
| Glioblastoma | D005909 | EFO_0000515 | — | 1 | 1 | — | — | — | 1 |
| Prostatic neoplasms | D011471 | — | C61 | 1 | 1 | — | — | — | 1 |
| Melanoma | D008545 | — | — | 1 | 1 | — | — | — | 1 |
| Airway obstruction | D000402 | — | — | 1 | 1 | — | — | — | 1 |
| Adenocarcinoma | D000230 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 2 | — | — | — | — | 2 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 1 | — | — | — | — | 1 |
| Central nervous system neoplasms | D016543 | — | — | 1 | — | — | — | — | 1 |
| Nervous system neoplasms | D009423 | — | — | 1 | — | — | — | — | 1 |
| Pleural effusion | D010996 | HP_0002202 | J90 | 1 | — | — | — | — | 1 |
| Malignant pleural effusion | D016066 | — | J91.0 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Choroid diseases | D015862 | HP_0000610 | H31.9 | — | — | — | — | 1 | 1 |
| Eye diseases | D005128 | EFO_0003966 | H44 | — | — | — | — | 1 | 1 |
| Angioid streaks | D000793 | EFO_1000805 | — | — | — | — | — | 1 | 1 |
| White dot syndromes | D000080363 | — | H30.14 | — | — | — | — | 1 | 1 |
| Multifocal choroiditis | D000080364 | — | — | — | — | — | — | 1 | 1 |
| Hereditary eye diseases | D015785 | — | — | — | — | — | — | 1 | 1 |
| Choroiditis | D002833 | — | H30.9 | — | — | — | — | 1 | 1 |
| Retinoblastoma | D012175 | — | — | — | — | — | — | 1 | 1 |
| Cerebrovascular disorders | D002561 | EFO_0003763 | I60-I69 | — | — | — | — | 1 | 1 |
| Optical coherence tomography | D041623 | — | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Verteporfin |
| INN | verteporfin |
| Description | (2R,2(1)S)-8-ethenyl-2(1),2(2)-bis(methoxycarbonyl)-17-(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-13-propanoic acid is the 2(1),2(2),17-trimethyl ester of (2R,2(1)S)-2(1),2(2)-dicarboxy-8-ethenyl-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-13,17-dipropanoic acid. It is a beta-substituted porphyrin, a carboxylic acid and a methyl ester. It is functionally related to a (2R,2(1)S)-2(1),2(2)-dicarboxy-8-ethenyl-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-13,17-dipropanoic acid. It is an enantiomer of a (2S,2(1)R)-8-ethenyl-2(1),2(2)-bis(methoxycarbonyl)-17-(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-13-propanoic acid. |
| Classification | Small molecule |
| Drug class | benzoporphyrin derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C=Cc1c(C)c2cc3nc(cc4[nH]c(cc5nc(cc1[nH]2)C(C)=C5CCC(=O)O)c(CCC(=O)OC)c4C)C1(C)C3=CC=C(C(=O)OC)C1C(=O)OC.C=Cc1c(C)c2cc3nc(cc4[nH]c(cc5nc(cc1[nH]2)C(C)=C5CCC(=O)OC)c(CCC(=O)O)c4C)C1(C)C3=CC=C(C(=O)OC)C1C(=O)OC |
Identifiers
| PDB | — |
| CAS-ID | 129497-78-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2218885 |
| ChEBI ID | — |
| PubChem CID | 5362420 |
| DrugBank | DB00460 |
| UNII ID | 0X9PA28K43 (ChemIDplus, GSRS) |
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Safety
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Adverse Events
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2,059 adverse events reported
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