Visudyne(verteporfin)
Visudyne (verteporfin) is a small molecule pharmaceutical. Verteporfin was first approved as Visudyne on 2000-04-12. It is used to treat choroidal neovascularization in the USA. It has been approved in Europe to treat degenerative myopia and macular degeneration.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| eye diseases | D005128 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Visudyne
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Verteporfin
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| VISUDYNE | Bausch Health Companies | N-021119 RX | 2000-04-12 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| visudyne | New Drug Application | 2023-02-24 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| choroidal neovascularization | — | D020256 | — |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J3396 | Injection, verteporfin, 0.1 mg |
Clinical
No data
Drug
General
| Drug common name | Verteporfin |
| INN | verteporfin |
| Description | (2R,2(1)S)-8-ethenyl-2(1),2(2)-bis(methoxycarbonyl)-17-(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-13-propanoic acid is the 2(1),2(2),17-trimethyl ester of (2R,2(1)S)-2(1),2(2)-dicarboxy-8-ethenyl-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-13,17-dipropanoic acid. It is a beta-substituted porphyrin, a carboxylic acid and a methyl ester. It is functionally related to a (2R,2(1)S)-2(1),2(2)-dicarboxy-8-ethenyl-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-13,17-dipropanoic acid. It is an enantiomer of a (2S,2(1)R)-8-ethenyl-2(1),2(2)-bis(methoxycarbonyl)-17-(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-13-propanoic acid. |
| Classification | Small molecule |
| Drug class | benzoporphyrin derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C=Cc1c(C)c2cc3nc(cc4[nH]c(cc5nc(cc1[nH]2)C(C)=C5CCC(=O)O)c(CCC(=O)OC)c4C)C1(C)C3=CC=C(C(=O)OC)C1C(=O)OC.C=Cc1c(C)c2cc3nc(cc4[nH]c(cc5nc(cc1[nH]2)C(C)=C5CCC(=O)OC)c(CCC(=O)O)c4C)C1(C)C3=CC=C(C(=O)OC)C1C(=O)OC |
Identifiers
| PDB | — |
| CAS-ID | 129497-78-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2218885 |
| ChEBI ID | — |
| PubChem CID | 5362420 |
| DrugBank | DB00460 |
| UNII ID | 0X9PA28K43 (ChemIDplus, GSRS) |
Target
No data
Variants
No data
Financial
No data
Trends
No data
Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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