Verquvo(vericiguat)
Verquvo (vericiguat) is a small molecule pharmaceutical. Vericiguat was first approved as Verquvo on 2021-01-19. It has been approved in Europe to treat heart failure.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| cardiovascular diseases | D002318 |
Trade Name
FDA
EMA
Verquvo
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Vericiguat
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| VERQUVO | Merck & Co | N-214377 RX | 2021-01-19 | 3 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| verquvo | New Drug Application | 2026-01-21 |
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
VERICIGUAT, VERQUVO, MERCK SHARP DOHME | |||
| 2026-01-19 | NCE | ||
HCPCS
No data
Clinical
Clinical Trials
44 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart failure | D006333 | EFO_0003144 | I50 | 4 | 6 | 3 | 6 | 13 | 31 |
| Inflammation | D007249 | MP_0001845 | — | — | — | — | 2 | — | 2 |
| Insulin resistance | D007333 | EFO_0002614 | E88.819 | — | 1 | — | 1 | — | 2 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | — | — | 1 | 1 | 2 |
| Infarction | D007238 | EFO_0009463 | — | — | — | — | 1 | 1 | 2 |
| Acute kidney injury | D058186 | — | N17 | — | — | — | 1 | — | 1 |
| Wounds and injuries | D014947 | — | T14.8 | — | — | — | 1 | — | 1 |
| Vascular diseases | D014652 | EFO_0004264 | I77 | — | — | — | 1 | — | 1 |
| Brain diseases | D001927 | — | G93.40 | — | — | — | 1 | — | 1 |
| Pulmonary arterial hypertension | D000081029 | — | — | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Left ventricular dysfunction | D018487 | — | — | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Metabolic syndrome | D024821 | EFO_0000195 | E88.810 | — | 2 | — | — | — | 2 |
| Chronic fatigue syndrome | D015673 | EFO_0004540 | G93.31 | — | 1 | — | — | — | 1 |
| Post-acute covid-19 syndrome | D000094024 | — | — | — | 1 | — | — | — | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | — | — | — | 1 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | 1 | — | — | — | 1 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | 1 | — | — | — | 1 |
| Metabolic diseases | D008659 | EFO_0000589 | E88.9 | — | 1 | — | — | — | 1 |
| Metabolism | D008660 | GO_0008152 | — | — | 1 | — | — | — | 1 |
| Energy metabolism | D004734 | — | — | — | 1 | — | — | — | 1 |
| Angina pectoris | D000787 | EFO_0003913 | I20 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Coronary artery disease | D003324 | — | I25.1 | 3 | — | — | — | — | 3 |
| Coronary disease | D003327 | — | — | 2 | — | — | — | — | 2 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | 2 | — | — | — | — | 2 |
| Pharmacokinetics | D010599 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chest pain | D002637 | — | R07.9 | — | — | — | — | 1 | 1 |
| Acute coronary syndrome | D054058 | EFO_0005672 | — | — | — | — | — | 1 | 1 |
| Chronic renal insufficiency | D051436 | — | N18 | — | — | — | — | 1 | 1 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | — | — | — | 1 | 1 |
| Aortic valve stenosis | D001024 | EFO_0000266 | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Vericiguat |
| INN | vericiguat |
| Description | Vericiguat is a pyrazolopyridine that is 5-fluoro-1H-pyrazolo[3,4-b]pyridine in which the amino hydrogen at position 1 has been substituted by a 2-fluorobenzyl group and the hydrogen at position 3 has been substituted by a 4,6-diamino-5-[(methoxycarbonyl)amino]pyrimidin-2-yl group. It is a soluble guanylate cyclase stimulator which is used for treatment of chronic heart failure. It has a role as a soluble guanylate cyclase activator, a vasodilator agent and an antihypertensive agent. It is an aminopyrimidine, a pyrazolopyridine, a carbamate ester and an organofluorine compound. |
| Classification | Small molecule |
| Drug class | guanaline cyclase activators |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COC(=O)Nc1c(N)nc(-c2nn(Cc3ccccc3F)c3ncc(F)cc23)nc1N |
Identifiers
| PDB | — |
| CAS-ID | 1350653-20-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4066936 |
| ChEBI ID | — |
| PubChem CID | 54674461 |
| DrugBank | DB15456 |
| UNII ID | LV66ADM269 (ChemIDplus, GSRS) |
Target
No data
Variants
No data
Financial
Revenue by drug
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Verquvo – Merck & Co
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Trends
PubMed Central
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Additional graphs summarizing 1,332 documents
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Safety
Black-box Warning
Black-box warning for: Verquvo
Adverse Events
Top Adverse Reactions
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989 adverse events reported
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