Veltuzumab
Empliciti (veltuzumab) is an antibody pharmaceutical. Veltuzumab was first approved as Empliciti on 2016-05-11. It has been approved in Europe to treat multiple myeloma. The pharmaceutical is active against B-lymphocyte antigen CD20.
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Commercial
Therapeutic Areas
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| empliciti | Biologic Licensing Application | 2022-03-22 |
Indications
FDA
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Agency Specific
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Clinical
Clinical Trials
18 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Aging | D000375 | GO_0007568 | R41.81 | — | — | 1 | — | — | 1 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | 1 | 1 | — | — | 1 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | 6 | 6 | — | — | — | 6 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 4 | 4 | — | — | — | 4 |
| Follicular lymphoma | D008224 | — | C82 | 3 | 3 | — | — | — | 3 |
| Waldenstrom macroglobulinemia | D008258 | — | C88.0 | 2 | 2 | — | — | — | 2 |
| Leukemia | D007938 | — | C95 | 2 | 2 | — | — | — | 2 |
| Lymphoid leukemia | D007945 | — | C91 | 2 | 2 | — | — | — | 2 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | 1 | — | — | — | 1 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | — | 1 | — | — | — | 1 |
| B-cell lymphoma marginal zone | D018442 | — | C88.4 | 1 | 1 | — | — | — | 1 |
| Mantle-cell lymphoma | D020522 | — | C83.1 | 1 | 1 | — | — | — | 1 |
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Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Esthetics | D004954 | — | — | — | — | — | — | 1 | 1 |
| Septic shock | D012772 | — | A48.3 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Veltuzumab |
| INN | veltuzumab |
| Description | Veltuzumab (humanized mab) |
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1743088 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | BPD4DGQ314 (ChemIDplus, GSRS) |
Target
Agency Approved
MS4A1
MS4A1
Organism
Homo sapiens
Gene name
MS4A1
Gene synonyms
CD20
NCBI Gene ID
Protein name
B-lymphocyte antigen CD20
Protein synonyms
B-lymphocyte cell-surface antigen B1, B-lymphocyte surface antigen B1, Bp35, CD20, CD20 antigen, CD20 receptor, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1, membrane-spanning 4-domains, subfamily A, member 1
Uniprot ID
Mouse ortholog
Ms4a1 (12482)
B-lymphocyte antigen CD20 (P19437)
Alternate
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Variants
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Financial
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Empliciti – Bristol Myers Squibb
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PubMed Central
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Safety
Black-box Warning
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Adverse Events
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