Vasopressin
Pitressin, Vasopressin, Vasostrict (vasopressin) is a protein pharmaceutical. Vasopressin was first approved as Pitressin tannate on 1982-01-01.
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Commercial
Therapeutic Areas
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Trade Name
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Vasopressin, Vasostrict (discontinued: Pitressin, Vasopressin, Vasostrict)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Vasopressin
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| VASOPRESSIN | American Regent | N-212593 RX | 2020-08-03 | 2 products, RLD, RS |
| VASOPRESSIN IN SODIUM CHLORIDE 0.9% | Baxter | N-217569 RX | 2023-09-29 | 2 products, RLD, RS |
| VASOSTRICT | Endo | N-204485 RX | 2014-04-17 | 4 products, RLD, RS |
| VASOPRESSIN IN SODIUM CHLORIDE 0.9% | Long Grove Pharmaceuticals | N-217766 RX | 2024-07-11 | 2 products, RLD, RS |
Show 2 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| vasopressin | ANDA | 2025-08-26 |
| vasopressin in 0.9% sodium chloride | New Drug Application | 2025-06-17 |
| vasostrict | New Drug Application | 2023-11-16 |
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Vasopressin, Vasostrict, Par Sterile Products | |||
| 9375478 | 2035-01-30 | U-1857 | |
| 9687526 | 2035-01-30 | U-1857 | |
| 9744209 | 2035-01-30 | U-1857 | |
| 9744239 | 2035-01-30 | U-1857 | |
| 9750785 | 2035-01-30 | DP | |
| 9919026 | 2035-01-30 | DP | |
| 9925233 | 2035-01-30 | U-1857 | |
| 9925234 | 2035-01-30 | U-1857 | |
| 9937223 | 2035-01-30 | U-1857 | |
| 9962422 | 2035-01-30 | U-1857 | |
| 9968649 | 2035-01-30 | U-1857 | |
| 9974827 | 2035-01-30 | U-1857 | |
| 9981006 | 2035-01-30 | U-1857 | |
| 10010575 | 2035-01-30 | U-1857 | |
ATC Codes
C: Cardiovascular system drugs
— C03: Diuretics
— C03X: Other diuretics in atc
— C03XA: Vasopressin antagonists, diuretics
H: Systemic hormonal preparations, excl. sex hormones and insulins
— H01: Pituitary and hypothalamic hormones and analogues
— H01B: Posterior pituitary lobe hormones
— H01BA: Vasopressin and analogues
— H01BA01: Vasopressin (argipressin)
HCPCS
No data
Clinical
Clinical Trials
406 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Diabetes insipidus | D003919 | — | E23.2 | 6 | 13 | 11 | 12 | 30 | 68 |
| Septic shock | D012772 | — | A48.3 | 1 | 11 | 11 | 9 | 16 | 44 |
| Shock | D012769 | — | R57.1 | 1 | 13 | 12 | 6 | 17 | 43 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | 4 | 2 | 17 | 7 | 30 |
| Syndrome | D013577 | — | — | 2 | 6 | 10 | 3 | 9 | 27 |
| Hyponatremia | D007010 | — | E87.1 | — | 2 | 13 | 2 | 9 | 26 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | 6 | 4 | 6 | 11 | 24 |
| Hepatorenal syndrome | D006530 | — | K76.7 | 1 | 4 | 8 | 3 | 6 | 20 |
| Acute kidney injury | D058186 | — | N17 | — | 2 | 3 | 5 | 9 | 19 |
| Nocturia | D053158 | — | R35.1 | — | 4 | 8 | 4 | 4 | 19 |
Show 64 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Inappropriate adh syndrome | D007177 | EFO_1000982 | E22.2 | 1 | 3 | 6 | — | 4 | 13 |
| Neurogenic diabetes insipidus | D020790 | — | — | 2 | 3 | 1 | — | 5 | 11 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | 3 | 4 | — | 3 | 9 |
| Polycystic kidney diseases | D007690 | — | Q61.3 | — | 3 | 4 | — | 2 | 8 |
| Autosomal dominant polycystic kidney | D016891 | EFO_1001496 | Q61.2 | — | 3 | 4 | — | 2 | 8 |
| Liver failure | D017093 | — | K72.9 | — | 1 | 1 | — | 5 | 7 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | 2 | 1 | — | 3 | 6 |
| Hepatic insufficiency | D048550 | — | — | — | — | 1 | — | 4 | 5 |
| Critical illness | D016638 | — | — | — | 1 | 1 | — | 3 | 5 |
| Anesthesia | D000758 | — | — | — | 1 | 1 | — | 3 | 4 |
Show 26 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Stroke | D020521 | EFO_0000712 | I63.9 | 1 | 1 | — | — | 2 | 4 |
| Nephrogenic diabetes insipidus | D018500 | — | N25.1 | — | 1 | — | — | 3 | 4 |
| Depression | D003863 | — | F33.9 | 1 | 1 | — | — | 1 | 3 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | — | 1 | — | — | 2 | 3 |
| Hemophilia b | D002836 | — | D67 | 1 | 1 | — | — | 1 | 3 |
| Cerebral hemorrhage | D002543 | — | — | — | 2 | — | — | — | 2 |
| Traumatic shock | D012774 | — | T79.4 | 1 | 1 | — | — | — | 2 |
| Nephritis | D009393 | — | N05 | — | 1 | — | — | — | 1 |
| Neonatal sepsis | D000071074 | — | — | — | 1 | — | — | — | 1 |
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | — | 1 | — | — | — | 1 |
Show 19 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 5 | — | — | — | 11 | 16 |
| Social psychology | D011593 | — | — | 2 | — | — | — | — | 2 |
| Hypopituitarism | D007018 | EFO_0001380 | E23.0 | 1 | — | — | — | 1 | 2 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | 2 | — | — | — | — | 2 |
| Pure autonomic failure | D054970 | — | — | 1 | — | — | — | — | 1 |
| Prostatic neoplasms | D011471 | — | C61 | 1 | — | — | — | — | 1 |
| Embolism | D004617 | — | — | 1 | — | — | — | — | 1 |
| Atherosclerosis | D050197 | EFO_0003914 | I25.1 | 1 | — | — | — | — | 1 |
| Intracranial arteriosclerosis | D002537 | EFO_1000860 | I67.2 | 1 | — | — | — | — | 1 |
| Fear | D005239 | — | — | 1 | — | — | — | — | 1 |
Show 3 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Dehydration | D003681 | — | E86.0 | — | — | — | — | 4 | 4 |
| Acute-on-chronic liver failure | D065290 | — | — | — | — | — | — | 4 | 4 |
| Blood platelet disorders | D001791 | — | — | — | — | — | — | 2 | 2 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | — | 2 | 2 |
| Von willebrand diseases | D014842 | EFO_0003910 | D68.0 | — | — | — | — | 2 | 2 |
| Pituitary diseases | D010900 | — | E23.7 | — | — | — | — | 2 | 2 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | — | — | — | 2 | 2 |
| Acute liver failure | D017114 | — | — | — | — | — | — | 2 | 2 |
| Meniere disease | D008575 | EFO_0006862 | H81.0 | — | — | — | — | 2 | 2 |
| Transient ischemic attack | D002546 | EFO_0003764 | G45.9 | — | — | — | — | 2 | 2 |
Show 76 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Vasopressin |
| INN | vasopressin injection |
| Description | Argipressin is the predominant form of mammalian vasopressin (antidiuretic hormone). It is a nonapeptide containing an arginine at residue 8 and two disulfide-linked cysteines at residues of 1 and 6. It has a role as a cardiovascular drug, a hematologic agent and a mitogen. It is a conjugate base of an argipressin(2+). |
| Classification | Protein |
| Drug class | vasoconstrictors (vasopressin derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O |
Identifiers
| PDB | — |
| CAS-ID | 113-79-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL373742 |
| ChEBI ID | 34543 |
| PubChem CID | 644077 |
| DrugBank | DB00067 |
| UNII ID | Y87Y826H08 (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Vasopressin – Eagle Pharmaceuticals
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Trends
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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2,107 adverse events reported
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