Varespladib
Varespladib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target phospholipase A2, membrane associated.
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Study first post date
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Commercial
No data
Clinical
Clinical Trials
17 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Acute coronary syndrome | D054058 | EFO_0005672 | — | — | 1 | 1 | — | — | 2 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Coronary artery disease | D003324 | — | I25.1 | — | 3 | — | — | — | 3 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | — | 2 | — | — | — | 2 |
| Coronary disease | D003327 | — | — | — | 2 | — | — | — | 2 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | 2 | — | — | — | 2 |
| Snake bites | D012909 | — | T63.0 | — | 2 | — | — | — | 2 |
| Vaso-occlusive crises | D000098644 | — | — | — | 1 | — | — | — | 1 |
| St elevation myocardial infarction | D000072657 | — | — | — | 1 | — | — | — | 1 |
| Non-st elevated myocardial infarction | D000072658 | — | — | — | 1 | — | — | — | 1 |
| Unstable angina | D000789 | EFO_1000985 | I20.0 | — | 1 | — | — | — | 1 |
| Acute chest syndrome | D056586 | EFO_0007129 | — | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 3 | — | — | — | — | 3 |
| Dengue | D003715 | — | A90 | 1 | — | — | — | — | 1 |
| Renal insufficiency | D051437 | — | N19 | 1 | — | — | — | — | 1 |
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | 1 | — | — | — | — | 1 |
| Eczema | D004485 | — | L30.9 | 1 | — | — | — | — | 1 |
| Dermatitis | D003872 | — | L30.9 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Blood pressure | D001794 | EFO_0004325 | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Varespladib |
| INN | varespladib |
| Description | Varespladib is a member of the class of indoles that is 1H-indole substituted by benzyl, ethyl, oxamoyl, and carboxymethoxy groups at positions 1, 2, 3, and 4, respectively. It is an oral secretory phospholipase A2 inhibitor and exhibits anti-inflammatory effects. It has a role as an EC 3.1.1.4 (phospholipase A2) inhibitor, an anti-inflammatory drug and an antidote. It is a member of indoles, a member of benzenes, an aromatic ether, a dicarboxylic acid monoamide, a monocarboxylic acid and a primary carboxamide. It is a conjugate acid of a varespladib(1-). |
| Classification | Small molecule |
| Drug class | phospholipase A2 inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cccc2n1Cc1ccccc1 |
Identifiers
| PDB | — |
| CAS-ID | 172732-68-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL148674 |
| ChEBI ID | — |
| PubChem CID | 155815 |
| DrugBank | DB11909 |
| UNII ID | 2Q3P98DATH (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
PLA2G2A
PLA2G2A
Organism
Homo sapiens
Gene name
PLA2G2A
Gene synonyms
PLA2B, PLA2L, RASF-A
NCBI Gene ID
Protein name
phospholipase A2, membrane associated
Protein synonyms
GIIC sPLA2, Group IIA phospholipase A2, Non-pancreatic secretory phospholipase A2, NPS-PLA2, Phosphatidylcholine 2-acylhydrolase 2A, phospholipase A2, group IIA (platelets, synovial fluid)
Uniprot ID
Mouse ortholog
Pla2g2a (18780)
phospholipase A2, membrane associated (Q60871)
Variants
No data
Financial
No data
Trends
PubMed Central
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Additional graphs summarizing 509 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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