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Drug ReportsVarespladib
Varespladib
Varespladib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target phospholipase A2, membrane associated.
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YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
No data
Clinical
Clinical Trials
17 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SchizophreniaD012559EFO_0000692F20—11——1
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameVarespladib
INNvarespladib
Description
Varespladib is a member of the class of indoles that is 1H-indole substituted by benzyl, ethyl, oxamoyl, and carboxymethoxy groups at positions 1, 2, 3, and 4, respectively. It is an oral secretory phospholipase A2 inhibitor and exhibits anti-inflammatory effects. It has a role as an EC 3.1.1.4 (phospholipase A2) inhibitor, an anti-inflammatory drug and an antidote. It is a member of indoles, a member of benzenes, an aromatic ether, a dicarboxylic acid monoamide, a monocarboxylic acid and a primary carboxamide. It is a conjugate acid of a varespladib(1-).
Classification
Small molecule
Drug classphospholipase A2 inhibitors
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Structure (InChI/SMILES or Protein Sequence)
CCc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cccc2n1Cc1ccccc1
Identifiers
PDB—
CAS-ID172732-68-2
RxCUI—
ChEMBL IDCHEMBL148674
ChEBI ID—
PubChem CID155815
DrugBankDB11909
UNII ID2Q3P98DATH (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
PLA2G2A
PLA2G2A
Organism
Homo sapiens
Gene name
PLA2G2A
Gene synonyms
PLA2B, PLA2L, RASF-A
NCBI Gene ID
Protein name
phospholipase A2, membrane associated
Protein synonyms
GIIC sPLA2, Group IIA phospholipase A2, Non-pancreatic secretory phospholipase A2, NPS-PLA2, Phosphatidylcholine 2-acylhydrolase 2A, phospholipase A2, group IIA (platelets, synovial fluid)
Uniprot ID
Mouse ortholog
Pla2g2a (18780)
phospholipase A2, membrane associated (Q60871)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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