Bextra, Valdyn (previously kudeq)(valdecoxib)
Bextra, Kudeq, Valdyn (valdecoxib) is a small molecule pharmaceutical. Valdecoxib was first approved as Bextra on 2001-11-16. It is used to treat dysmenorrhea, osteoarthritis, and rheumatoid arthritis in the USA. It has been approved in Europe to treat dysmenorrhea, osteoarthritis, and rheumatoid arthritis. The pharmaceutical is active against prostaglandin G/H synthase 2. In addition, it is known to target carbonic anhydrase 12.
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Abbreviated New Drug Application (ANDA)
Valdecoxib
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| BEXTRA | G.D. Searle | N-021341 DISCN | 2001-11-16 | 2 products |
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Clinical
Clinical Trials
31 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pain | D010146 | EFO_0003843 | R52 | — | 1 | 5 | 3 | 1 | 10 |
| Postoperative pain | D010149 | — | G89.18 | — | — | 5 | 3 | 1 | 9 |
| Low back pain | D017116 | HP_0003419 | M54.5 | — | 1 | — | 1 | 1 | 3 |
| Acute pain | D059787 | — | R52 | — | 1 | — | 1 | — | 2 |
| Back pain | D001416 | HP_0003418 | M54 | — | 1 | — | 1 | — | 2 |
| Sprains and strains | D013180 | — | — | — | — | — | 2 | — | 2 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | — | — | 1 | — | 1 |
| Arthritis | D001168 | HP_0001369 | M05-M14 | — | — | — | 1 | — | 1 |
| Rupture | D012421 | — | — | — | — | — | 1 | — | 1 |
| Delirium | D003693 | — | R41.0 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | 1 | 2 | — | — | 3 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | 1 | 2 | — | — | 3 |
| Pharyngitis | D010612 | — | R07.0 | — | 1 | 1 | — | — | 2 |
| Toothache | D014098 | — | K08.89 | — | — | 2 | — | — | 2 |
| Pancreatitis | D010195 | HP_0001733 | K85 | — | 1 | 1 | — | — | 1 |
| Endoscopic retrograde cholangiopancreatography | D002760 | — | — | — | 1 | 1 | — | — | 1 |
| Hallux valgus | D006215 | HP_0001822 | — | — | — | 1 | — | — | 1 |
| Laparoscopic cholecystectomy | D017081 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postoperative complications | D011183 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Platelet aggregation | D010974 | GO_0070527 | — | — | — | — | — | 1 | 1 |
| Neoplasms | D009369 | — | C80 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Valdecoxib |
| INN | valdecoxib |
| Description | Valdecoxib is a member of the class of isoxazoles that is isoxazole which is substituted at positions 3, 4 and 5 by phenyl, p-sulfamoylphenyl and methyl groups, respectively. A selective cyclooxygenase 2-inhibitor, it used as a nonsteroidal anti-inflammatory drug (NSAID) for the treatment of arthritis from 2001 until 2005, when it was withdrawn following concerns of an associated increased risk of heart attack and stroke. It has a role as a non-steroidal anti-inflammatory drug, a cyclooxygenase 2 inhibitor, a non-narcotic analgesic, an antirheumatic drug and an antipyretic. It is a member of isoxazoles and a sulfonamide. |
| Classification | Small molecule |
| Drug class | cyclooxygenase-2 inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 181695-72-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL865 |
| ChEBI ID | 63634 |
| PubChem CID | 119607 |
| DrugBank | DB00580 |
| UNII ID | 2919279Q3W (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
CA2
CA2
Organism
Homo sapiens
Gene name
CA2
Gene synonyms
NCBI Gene ID
Protein name
carbonic anhydrase 2
Protein synonyms
CA-II, CAC, Carbonate dehydratase II, carbonic anhydrase B, Carbonic anhydrase C, Carbonic anhydrase II, carbonic dehydratase, Cyanamide hydratase CA2, epididymis luminal protein 76, epididymis secretory protein Li 282
Uniprot ID
Mouse ortholog
Car2 (12349)
carbonic anhydrase 2 (Q9DCY9)
Variants
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Valdecoxib
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Safety
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15,509 adverse events reported
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