Vaborbactam
Vabomere, Vaborem (vaborbactam) is a small molecule pharmaceutical. Vaborbactam was first approved as Vabomere on 2017-08-29. It is used to treat bacterial infections in the USA. It has been approved in Europe to treat bacteremia, bacterial infections, pneumonia, respiratory tract infections, and urinary tract infections amongst others.
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Commercial
Therapeutic Areas
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| vabomere | New Drug Application | 2024-12-12 |
Indications
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Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
MEROPENEM / VABORBACTAM, VABOMERE, REMPEX | |||
| 2027-08-29 | GAIN | ||
| 2022-08-29 | NCE | ||
HCPCS
Code | Description |
|---|---|
| J2186 | Injection, meropenem and vaborbactam, 10mg/10mg (20mg) |
Clinical
Clinical Trials
14 clinical trials
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Indications Phases 4
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | — | 1 | — | — | — | 1 |
| Urinary tract infections | D014552 | EFO_0003103 | N39.0 | — | 1 | — | — | — | 1 |
| Communicable diseases | D003141 | — | — | — | 1 | — | — | — | 1 |
| Pyelonephritis | D011704 | EFO_1001141 | N10-N16 | — | 1 | — | — | — | 1 |
Indications Phases 1
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Vaborbactam |
| INN | vaborbactam |
| Description | Vaborbactam (INN) is a non-β-lactam β-lactamase inhibitor discovered by Rempex Pharmaceuticals, a subsidiary of The Medicines Company. While not effective as an antibiotic by itself, it restores potency to existing antibiotics by inhibiting the β-lactamase enzymes that would otherwise degrade them. When combined with an appropriate antibiotic it can be used for the treatment of gram-negative bacterial infections.
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| Classification | Small molecule |
| Drug class | beta-lactamase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C(O)C[C@@H]1CC[C@H](NC(=O)Cc2cccs2)B(O)O1 |
Identifiers
| PDB | — |
| CAS-ID | 1360457-46-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3317857 |
| ChEBI ID | — |
| PubChem CID | 56649692 |
| DrugBank | DB12107 |
| UNII ID | 1C75676F8V (ChemIDplus, GSRS) |
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Safety
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83 adverse events reported
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