Vabomere, Vaborem(vaborbactam)
Vabomere, Vaborem (vaborbactam) is a small molecule pharmaceutical. Vaborbactam was first approved as Vabomere on 2017-08-29. It is used to treat bacterial infections in the USA. It has been approved in Europe to treat bacteremia, bacterial infections, pneumonia, respiratory tract infections, and urinary tract infections amongst others.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Combinations
Vabomere
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Meropenem
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Vaborbactam
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| VABOMERE | REMPEX | N-209776 RX | 2017-08-29 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| vabomere | New Drug Application | 2023-10-19 |
Indications
FDA
EMA
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Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
MEROPENEM / VABORBACTAM, VABOMERE, REMPEX | |||
| 2027-08-29 | GAIN | ||
| 2022-08-29 | NCE | ||
HCPCS
Code | Description |
|---|---|
| J2186 | Injection, meropenem and vaborbactam, 10mg/10mg (20mg) |
Clinical
Clinical Trials
12 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | 1 | — | 2 | — | 1 | 4 |
| Communicable diseases | D003141 | — | — | 1 | — | 1 | — | 1 | 3 |
| Ventilator-associated pneumonia | D053717 | EFO_1001865 | J95.851 | — | — | 2 | — | — | 2 |
| Pneumonia | D011014 | EFO_0003106 | — | — | — | 2 | — | — | 2 |
| Bacterial pneumonia | D018410 | EFO_1001272 | J15.9 | — | — | 2 | — | — | 2 |
| Urinary tract infections | D014552 | EFO_0003103 | N39.0 | — | — | 2 | — | — | 2 |
| Pyelonephritis | D011704 | EFO_1001141 | N10-N16 | — | — | 2 | — | — | 2 |
| Iatrogenic disease | D007049 | — | — | — | — | 1 | — | — | 1 |
| Healthcare-associated pneumonia | D000077299 | — | — | — | — | 1 | — | — | 1 |
| Intraabdominal infections | D059413 | — | — | — | — | 1 | — | — | 1 |
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Indications Phases 2
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 5 | — | — | — | — | 5 |
| Bacterial infections | D001424 | — | A49 | 4 | — | — | — | — | 4 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | — | — | — | — | 1 | 1 |
| Acute lung injury | D055371 | EFO_0004610 | — | — | — | — | — | 1 | 1 |
| Cross infection | D003428 | — | — | — | — | — | — | 1 | 1 |
| Newborn respiratory distress syndrome | D012127 | — | P22 | — | — | — | — | 1 | 1 |
| Multiple drug resistance | D018432 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Vaborbactam |
| INN | vaborbactam |
| Description | Vaborbactam (INN) is a non-β-lactam β-lactamase inhibitor discovered by Rempex Pharmaceuticals, a subsidiary of The Medicines Company. While not effective as an antibiotic by itself, it restores potency to existing antibiotics by inhibiting the β-lactamase enzymes that would otherwise degrade them. When combined with an appropriate antibiotic it can be used for the treatment of gram-negative bacterial infections.
|
| Classification | Small molecule |
| Drug class | beta-lactamase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C(O)C[C@@H]1CC[C@H](NC(=O)Cc2cccs2)B(O)O1 |
Identifiers
| PDB | — |
| CAS-ID | 1360457-46-0 |
| RxCUI | 1945213 |
| ChEMBL ID | CHEMBL3317857 |
| ChEBI ID | — |
| PubChem CID | 56649692 |
| DrugBank | DB12107 |
| UNII ID | 1C75676F8V (ChemIDplus, GSRS) |
Target
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Trends
PubMed Central
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Safety
Black-box Warning
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Adverse Events
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72 adverse events reported
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