VERUCERFONT
Verucerfont is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target CRHR1-IT1-CRHR1 protein.
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Commercial
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Clinical
Clinical Trials
10 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Depressive disorder | D003866 | EFO_1002014 | F32.A | 2 | 1 | — | — | — | 3 |
| Depression | D003863 | — | F33.9 | — | 1 | — | — | — | 1 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | 1 | — | — | — | 1 |
| Irritable bowel syndrome | D043183 | EFO_0000555 | K58 | — | 1 | — | — | — | 1 |
| Syndrome | D013577 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | 3 | — | — | — | — | 3 |
| Social phobia | D000072861 | EFO_1001917 | F40.1 | 1 | — | — | — | — | 1 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | VERUCERFONT |
| INN | verucerfont |
| Description | Verucerfont (GSK-561,679) is a drug developed by GlaxoSmithKline which acts as a CRF-1 antagonist. Corticotropin releasing factor (CRF), also known as Corticotropin releasing hormone, is an endogenous peptide hormone which is released in response to various triggers such as chronic stress, and activates the two corticotropin-releasing hormone receptors CRH-1 and CRH-2. This then triggers the release of corticotropin (ACTH), another hormone which is involved in the physiological response to stress.
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| Classification | Small molecule |
| Drug class | CRF-1 (corticotropin releasing factor) receptor antagonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC[C@H](Nc1cc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12)c1nc(C)no1 |
Identifiers
| PDB | — |
| CAS-ID | 885220-61-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1287935 |
| ChEBI ID | — |
| PubChem CID | 11596613 |
| DrugBank | — |
| UNII ID | X60608B091 (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
LINC02210-CRHR1
LINC02210-CRHR1
Variants
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Financial
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Trends
PubMed Central
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Additional graphs summarizing 169 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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