VEROSUDIL
Verosudil is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target rho-associated protein kinase 1 and rho-associated protein kinase 2.
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FDA approval date
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Study first post date
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Commercial
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Clinical
Clinical Trials
12 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Glaucoma | D005901 | EFO_0000516 | H40 | — | 10 | — | — | — | 10 |
| Ocular hypertension | D009798 | EFO_1001069 | H40.0 | — | 8 | — | — | — | 8 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | 5 | — | — | — | 5 |
| Open-angle glaucoma | D005902 | EFO_0004190 | H40.1 | — | 4 | — | — | — | 4 |
| Angle-closure glaucoma | D015812 | — | — | — | 1 | — | — | — | 1 |
| Exfoliation syndrome | D017889 | EFO_0004235 | — | — | 1 | — | — | — | 1 |
| Syndrome | D013577 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | VEROSUDIL |
| INN | verosudil |
| Description | Verosudil (AR-12286) is a drug which acts as a potent and selective inhibitor of the enzyme Rho kinase, and has been investigated for the treatment of glaucoma.
|
| Classification | Small molecule |
| Drug class | vasodilators (undefined group): Rho protein kinase (ROCK) inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN(C)C(C(=O)Nc1ccc2c(=O)[nH]ccc2c1)c1ccsc1 |
Identifiers
| PDB | — |
| CAS-ID | 1414854-42-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3545065 |
| ChEBI ID | — |
| PubChem CID | 66906051 |
| DrugBank | — |
| UNII ID | MAF34143WM (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
ROCK1
ROCK1
ROCK2
ROCK2
Organism
Homo sapiens
Gene name
ROCK1
Gene synonyms
NCBI Gene ID
Protein name
rho-associated protein kinase 1
Protein synonyms
p160 ROCK-1, p160ROCK, Renal carcinoma antigen NY-REN-35, Rho-associated, coiled-coil-containing protein kinase 1, Rho-associated, coiled-coil-containing protein kinase I, ROCK-I
Uniprot ID
Mouse ortholog
Rock1 (19877)
rho-associated protein kinase 1 (Q8C7H0)
Variants
No data
Financial
No data
Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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