VERINURAD
Verinurad is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target solute carrier family 22 member 12.
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Commercial
No data
Clinical
Clinical Trials
22 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic renal insufficiency | D051436 | — | N18 | 4 | 1 | — | — | — | 5 |
| Hyperuricemia | D033461 | — | — | — | 3 | — | — | — | 3 |
| Gout | D006073 | EFO_0004274 | M10 | 1 | 3 | — | — | — | 3 |
| Asymptomatic diseases | D058070 | — | — | 1 | 2 | — | — | — | 2 |
| Albuminuria | D000419 | EFO_0004285 | R80.9 | — | 1 | — | — | — | 1 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 1 | — | — | — | 1 |
| Heart failure | D006333 | EFO_0003144 | I50 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Kidney diseases | D007674 | EFO_0003086 | N08 | 3 | — | — | — | — | 3 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | VERINURAD |
| INN | verinurad |
| Description | Verinurad is a selective URAT1 inhibitor developed for gout and heart failure by AstraZeneca.
|
| Classification | Small molecule |
| Drug class | urate transporter inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)(Sc1ccncc1-c1ccc(C#N)c2ccccc12)C(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 1352792-74-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3707347 |
| ChEBI ID | — |
| PubChem CID | 54767229 |
| DrugBank | DB11873 |
| UNII ID | 12WJ62D047 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
SLC22A12
SLC22A12
Organism
Homo sapiens
Gene name
SLC22A12
Gene synonyms
OATL4, URAT1
NCBI Gene ID
Protein name
solute carrier family 22 member 12
Protein synonyms
Organic anion transporter 4-like protein, Renal-specific transporter, RST, solute carrier family 22 (organic anion/cation transporter), member 12, solute carrier family 22 (organic anion/urate transporter), member 12, URAT1, Urate anion exchanger 1, urate anion transporter 1, urate transporter 1, Urate:anion antiporter SLC22A12
Uniprot ID
Mouse ortholog
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—
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 144 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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