Tradename | Proper name | Company | Number | Date | Products |
---|---|---|---|---|---|
Stelara | ustekinumab | Johnson & Johnson | N-125261 RX | 2009-09-25 | 3 products |
Stelara | ustekinumab | Johnson & Johnson | N-761044 RX | 2016-09-23 | 1 products |
Indication | Ontology | MeSH | ICD-10 |
---|---|---|---|
crohn disease | EFO_0000384 | D003424 | K50 |
psoriatic arthritis | EFO_0003778 | D015535 | L40.5 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Psoriasis | D011565 | EFO_0000676 | L40 | 7 | 3 | 31 | 10 | 17 | 68 |
Crohn disease | D003424 | EFO_0000384 | K50 | 4 | 7 | 13 | 7 | 23 | 52 |
Ulcerative colitis | D003093 | EFO_0000729 | K51 | 1 | 1 | 4 | 2 | 12 | 20 |
Inflammatory bowel diseases | D015212 | EFO_0003767 | — | — | — | 5 | 2 | 6 | 13 |
Cardiovascular diseases | D002318 | HP_0001626 | — | — | — | — | 1 | — | 1 |
Lamellar ichthyosis | D017490 | — | Q80 | — | — | — | 1 | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Psoriatic arthritis | D015535 | EFO_0003778 | L40.5 | — | 3 | 7 | — | 10 | 20 |
Systemic lupus erythematosus | D008180 | HP_0002725 | M32 | — | 1 | 2 | — | — | 3 |
Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 1 | 3 | 1 | — | — | 3 |
Colitis | D003092 | EFO_0003872 | K52.9 | — | — | 3 | — | — | 3 |
Axial spondyloarthritis | D000089183 | — | — | — | — | 2 | — | — | 2 |
Juvenile arthritis | D001171 | EFO_1002007 | M08 | 1 | — | 1 | — | — | 2 |
Pouchitis | D019449 | EFO_0003921 | K91.850 | — | — | 1 | — | — | 1 |
Dermatomyositis | D003882 | EFO_0000398 | M33 | — | — | 1 | — | — | 1 |
Polymyositis | D017285 | EFO_0003063 | M33.2 | — | — | 1 | — | — | 1 |
Ankylosis | D000844 | — | M24.6 | — | — | 1 | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Atopic dermatitis | D003876 | EFO_0000274 | L20 | — | 2 | — | — | 2 | 4 |
Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | 1 | — | — | 3 | 4 |
Ankylosing spondylitis | D013167 | EFO_0003898 | M45 | — | 1 | — | — | 2 | 3 |
Giant cell arteritis | D013700 | EFO_1001209 | M31.6 | 1 | 2 | — | — | — | 2 |
Uveitis | D014605 | HP_0000554 | H20.9 | 1 | 2 | — | — | — | 2 |
Autoimmune diseases | D001327 | HP_0002960 | M30-M36 | — | 1 | — | — | — | 1 |
Graft vs host disease | D006086 | — | D89.81 | — | 1 | — | — | — | 1 |
Bullous pemphigoid | D010391 | EFO_0007187 | L12 | — | 1 | — | — | — | 1 |
Behcet syndrome | D001528 | EFO_0003780 | M35.2 | — | 1 | — | — | — | 1 |
Hidradenitis suppurativa | D017497 | — | L73.2 | — | 1 | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Healthy volunteers/patients | — | — | — | 6 | — | — | — | — | 6 |
Ichthyosis | D007057 | — | E50.8 | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Spondylarthritis | D025241 | — | — | — | — | — | — | 1 | 1 |
Inflammation | D007249 | MP_0001845 | — | — | — | — | — | 1 | 1 |
Atherosclerosis | D050197 | EFO_0003914 | I25.1 | — | — | — | — | 1 | 1 |
Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | — | — | 1 | 1 |
Alzheimer disease | D000544 | EFO_0000249 | F03 | — | — | — | — | 1 | 1 |
Drug common name | Ustekinumab |
INN | ustekinumab |
Description | Ustekinumab, sold under the brand name Stelara, is a human monoclonal antibody used to treat psoriasis. It is also approved to treat Crohn's disease in the United States, Israel and Australia, and ulcerative colitis in the U.S., and in the European Union (EU) among people who have not responded to more traditional treatments. |
Classification | Antibody |
Drug class | monoclonal antibodies |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | >3HMW:H|USTEKINUMAB FAB HEAVY CHAIN
EVQLVQSGAEVKKPGESLKISCKGSGYSFTTYWLGWVRQMPGKGLDWIGIMSPVDSDIRYSPSFQGQVTMSVDKSITTAY
LQWNSLKASDTAMYYCARRRPGQGYFDFWGQGTLVTVSSSSTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSW
NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTH
>3HMW:L|USTEKINUMAB FAB LIGHT CHAIN
DIQMTQSPSSLSASVGDRVTITCRASQGISSWLAWYQQKPEKAPKSLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQP
EDFATYYCQQYNIYPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
PDB | 3HMW, 3HMX |
CAS-ID | — |
RxCUI | — |
ChEMBL ID | CHEMBL1201835 |
ChEBI ID | — |
PubChem CID | — |
DrugBank | DB05679 |
UNII ID | FU77B4U5Z0 (ChemIDplus, GSRS) |