PharmaKB logo
Company Reports
Company Reports
Drug Reports
Drug Reports
Disease Reports
Disease Reports
Sets
Sets
Favorites
Favorites
Log in
Log in
AboutPricing
Drug ReportsUmeclidinium
Anoro ellipta, Incruse ellipta (previously incruse)(umeclidinium)
Anoro, Anoro Ellipta, Ellipta, Incruse, Incruse Ellipta, Laventair, Laventair Ellipta, Rolufta, Rolufta Ellipta (umeclidinium) is a small molecule pharmaceutical. Umeclidinium was first approved as Anoro ellipta on 2013-12-18. It is used to treat chronic bronchitis and pulmonary emphysema in the USA. It has been approved in Europe to treat chronic obstructive pulmonary disease. It is known to target muscarinic acetylcholine receptor M5, muscarinic acetylcholine receptor M4, muscarinic acetylcholine receptor M1, muscarinic acetylcholine receptor M3, and muscarinic acetylcholine receptor M2.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Plot placeholder
Mock data
Subscribe for the real data
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
respiratory tract diseasesD012140
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Incruse ellipta
Combinations
Anoro ellipta, Trelegy ellipta
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Umeclidinium bromide
+
Vilanterol trifenatate
Tradename
Company
Number
Date
Products
ANORO ELLIPTAGSKN-203975 RX2013-12-18
1 products, RLD, RS
Umeclidinium bromide
Tradename
Company
Number
Date
Products
INCRUSE ELLIPTAGSKN-205382 RX2014-04-30
1 products, RLD, RS
Fluticasone furoate
+
Umeclidinium bromide
+
Vilanterol trifenatate
Tradename
Company
Number
Date
Products
TRELEGY ELLIPTAGSKN-209482 RX2017-09-18
2 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
anoro elliptaNew Drug Application2023-06-02
incruse elliptaNew Drug Application2023-12-13
trelegy elliptaNew Drug Application2023-06-02
umeclidinium and vilanterol elliptaNDA authorized generic2024-11-22
umeclidinium and villanterol elliptaNDA authorized generic2024-11-22
umecta mousseunapproved drug other2017-12-27
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
obstructive sleep apneaEFO_0003918D020181G47.33
chronic bronchitis—D029481J42
pulmonary emphysema—D011656J43
allergic rhinitis perennialEFO_1001417D012221J30.89
Agency Specific
FDA
EMA
Expiration
Code
FLUTICASONE FUROATE / UMECLIDINIUM BROMIDE / VILANTEROL TRIFENATATE, TRELEGY ELLIPTA, GLAXOSMITHKLINE
2023-09-09I-843, NS
Patent Expiration
Patent
Expires
Flag
FDA Information
Fluticasone Furoate / Umeclidinium Bromide / Vilanterol Trifenatate, Trelegy Ellipta, Glaxosmithkline
97507262030-11-29DP
110902942030-11-29U-3202, U-3203
87462422030-10-11DP
85342812030-03-08DP
81619682028-02-05DP
74888272027-12-18DS, DP
93333102027-10-02DP
85113042027-06-14DPU-1476, U-2954
81832572025-07-27U-1476, U-2128, U-2129
74393932025-05-21DS, DPU-1476, U-2127, U-2957
74984402025-04-27DS, DP
83095722025-04-27U-1476, U-2129
Umeclidinium Bromide, Incruse Ellipta, Glaxo Grp England
82015562029-02-05DP
ATC Codes
R: Respiratory system drugs
— R03: Drugs for obstructive airway diseases
— R03A: Adrenergics, inhalants
— R03AL: Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids
— R03AL03: Vilanterol and umeclidinium bromide
— R03AL08: Vilanterol, umeclidinium bromide and fluticasone furoate
— R03B: Other drugs for obstructive airway diseases, inhalants in atc
— R03BB: Anticholinergics inhalants for obstructive airway diseases
— R03BB07: Umeclidinium bromide
HCPCS
No data
Clinical
Clinical Trials
115 clinical trials
View more details
Plot placeholder
Mock data
Subscribe for the real data
Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Chronic obstructive pulmonary diseaseD029424EFO_0000341J44.9161236221398
Lung diseasesD008171EFO_0003818J98.4263012757
Obstructive lung diseasesD008173——14169534
AsthmaD001249EFO_0000270J452561—13
Heart failureD006333EFO_0003144I50———1—1
Respiratory aspirationD053120EFO_1001839————1—1
Respiratory tract diseasesD012140—————1—1
Respiration disordersD012120—J00-J99———1—1
Chronic bronchitisD029481—J42———1—1
BronchitisD001991—J40———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Non-small-cell lung carcinomaD002289————1——1
Lung neoplasmsD008175—C34.90——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HyperhidrosisD006945——12———3
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Renal insufficiencyD051437—N191————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Intracranial hypertensionD019586EFO_1000992—————11
Arm injuriesD001134——————11
DyspneaD004417—R06.0————11
Acupuncture therapyD015670——————11
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common nameUmeclidinium
INNumeclidinium bromide
Description
Umeclidinium bromide is a quaternary ammonium salt that is the bromide salt of umeclidinium. Used in combination with vilanterol for long-term maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease. It has a role as a muscarinic antagonist. It is a quaternary ammonium salt and an organic bromide salt. It contains an umeclidinium.
Classification
Small molecule
Drug classmuscarinic receptor agonists/antagonists; quaternary ammonium derivatives: muscarinic receptor agonists/antagonists
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCOCc3ccccc3)(CC1)CC2
Identifiers
PDB—
CAS-ID869113-09-7
RxCUI1487512
ChEMBL IDCHEMBL1187833
ChEBI ID—
PubChem CID11519069
DrugBankDB09076
UNII ID7AN603V4JV (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CHRM5
CHRM5
CHRM4
CHRM4
CHRM1
CHRM1
CHRM3
CHRM3
CHRM2
CHRM2
Organism
Homo sapiens
Gene name
CHRM5
Gene synonyms
NCBI Gene ID
1133
Protein name
muscarinic acetylcholine receptor M5
Protein synonyms
acetylcholine receptor, muscarinic 5
Uniprot ID
Q96RG7
Mouse ortholog
Chrm5 (213788)
muscarinic acetylcholine receptor M5 (Q920H4)
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Trelegy ellipta – Innoviva
Plot placeholder
Mock data
Subscribe for the real data
Plot placeholder
Mock data
Subscribe for the real data
Anoro ellipta – Innoviva
Plot placeholder
Mock data
Subscribe for the real data
Plot placeholder
Mock data
Subscribe for the real data
Tabular view
Estimated US medical usage
Umeclidinium
+
Vilanterol
+
Fluticasone
Total medical expenditures per year (USD, in millions)
Plot placeholder
Mock data
Subscribe for the real data
Number of persons purchased
Plot placeholder
Mock data
Subscribe for the real data
Number of purchases
Plot placeholder
Mock data
Subscribe for the real data
Refill frequency
Plot placeholder
Mock data
Subscribe for the real data
Price per prescription (USD)
Plot placeholder
Mock data
Subscribe for the real data
Umeclidinium
Total medical expenditures per year (USD, in millions)
Plot placeholder
Mock data
Subscribe for the real data
Number of persons purchased
Plot placeholder
Mock data
Subscribe for the real data
Number of purchases
Plot placeholder
Mock data
Subscribe for the real data
Refill frequency
Plot placeholder
Mock data
Subscribe for the real data
Price per prescription (USD)
Plot placeholder
Mock data
Subscribe for the real data
Umeclidinium
+
Vilanterol
Total medical expenditures per year (USD, in millions)
Plot placeholder
Mock data
Subscribe for the real data
Number of persons purchased
Plot placeholder
Mock data
Subscribe for the real data
Number of purchases
Plot placeholder
Mock data
Subscribe for the real data
Refill frequency
Plot placeholder
Mock data
Subscribe for the real data
Price per prescription (USD)
Plot placeholder
Mock data
Subscribe for the real data
Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Plot placeholder
Mock data
Subscribe for the real data
Additional graphs summarizing 1,458 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Plot placeholder
Mock data
Subscribe for the real data
44,342 adverse events reported
View more details
© 2020-2025 Collaborative Drug Discovery Inc. (CDD) | Terms of Use