UPRIFOSBUVIR
Uprifosbuvir is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Clinical
Clinical Trials
8 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatitis c | D006526 | — | B19.2 | 3 | 6 | — | — | — | 8 |
| Hepatitis | D006505 | HP_0012115 | K75.9 | 1 | 6 | — | — | — | 6 |
| Hepatitis a | D006506 | EFO_0007305 | B15 | 1 | 6 | — | — | — | 6 |
| Chronic hepatitis c | D019698 | EFO_0004220 | B18.2 | 2 | 2 | — | — | — | 3 |
| Liver diseases | D008107 | HP_0002910 | K70-K77 | — | 1 | — | — | — | 1 |
| Infections | D007239 | EFO_0000544 | — | — | 1 | — | — | — | 1 |
| Gastrointestinal diseases | D005767 | — | — | — | 1 | — | — | — | 1 |
| Communicable diseases | D003141 | — | — | — | 1 | — | — | — | 1 |
| Virus diseases | D014777 | — | B34 | — | 1 | — | — | — | 1 |
| Rna virus infections | D012327 | — | — | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Renal insufficiency | D051437 | HP_0000083 | N19 | 1 | — | — | — | — | 1 |
| Liver failure | D017093 | HP_0001399 | K72.9 | 1 | — | — | — | — | 1 |
| Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | UPRIFOSBUVIR |
| INN | uprifosbuvir |
| Description | Uprifosbuvir (MK-3682) is an antiviral drug developed for the treatment of hepatitis C. It is a nucleotide analogue which acts as an NS5B RNA polymerase inhibitor. As of 2019 it was in Phase III human clinical trials.
|
| Classification | Small molecule |
| Drug class | phosphoro-derivatives; antivirals: RNA polymerase (NS5B) inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)OC(=O)[C@@H](C)N[P@@](=O)(OC[C@H]1O[C@@H](n2ccc(=O)[nH]c2=O)[C@](C)(Cl)[C@@H]1O)Oc1ccccc1 |
Identifiers
| PDB | — |
| CAS-ID | 1496551-77-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3833371 |
| ChEBI ID | — |
| PubChem CID | 90055716 |
| DrugBank | DB15206 |
| UNII ID | JW31KPS26S (ChemIDplus, GSRS) |
Target
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Safety
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Adverse Events
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