ULIXERTINIB
Ulixertinib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target mitogen-activated protein kinase 3 and mitogen-activated protein kinase 1.
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Events Timeline
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YTD
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2Y
5Y
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Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
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Completion date
Results first post date
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Commercial
No data
Clinical
Clinical Trials
18 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | — | — | — | — | 1 |
| Melanoma | D008545 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | ULIXERTINIB |
| INN | ulixertinib |
| Description | Ulixertinib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target mitogen-activated protein kinase 3 and mitogen-activated protein kinase 1. |
| Classification | Small molecule |
| Drug class | tyrosine kinase inhibitors: epidermal growth factor receptor (EGFR) inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)Nc1cc(-c2c[nH]c(C(=O)N[C@H](CO)c3cccc(Cl)c3)c2)c(Cl)cn1 |
Identifiers
| PDB | — |
| CAS-ID | 869886-67-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3590106 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 16ZDH50O1U (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
MAPK3
MAPK3
MAPK1
MAPK1
Organism
Homo sapiens
Gene name
MAPK3
Gene synonyms
ERK1, PRKM3
NCBI Gene ID
Protein name
mitogen-activated protein kinase 3
Protein synonyms
ERK-1, ERT2, Extracellular signal-regulated kinase 1, extracellular signal-related kinase 1, Insulin-stimulated MAP2 kinase, MAP kinase isoform p44, MAPK 1, Microtubule-associated protein 2 kinase, p44-ERK1, p44-MAPK
Uniprot ID
Mouse ortholog
Mapk3 (26417)
mitogen-activated protein kinase 3 (Q91YW5)
Variants
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
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Adverse Events
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