Txa127
Txa127 is a protein pharmaceutical. It is currently being investigated in clinical studies. It is known to target type-2 angiotensin II receptor and proto-oncogene Mas.
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Clinical Trials
145 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | 11 | 7 | 6 | 6 | 1 | 31 |
| Heart failure | D006333 | HP_0001635 | I50 | 1 | 3 | 1 | 4 | — | 8 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 2 | — | — | 3 | 1 | 6 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 3 | 1 | — | 1 | — | 5 |
| Ischemic stroke | D000083242 | — | — | — | 2 | 1 | 1 | — | 4 |
| Diabetic nephropathies | D003928 | EFO_0000401 | — | — | 1 | — | 2 | — | 3 |
| Cardiotoxicity | D066126 | EFO_1001482 | — | — | 1 | 1 | 1 | — | 3 |
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | — | — | 2 | — | 2 |
| Iga glomerulonephritis | D005922 | EFO_0004194 | — | — | 1 | 1 | 1 | — | 2 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | 1 | 1 | — | 2 |
Show 5 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | — | U07.1 | 2 | 7 | 3 | — | 3 | 11 |
| Neoplasms | D009369 | — | C80 | 2 | 1 | 1 | — | — | 4 |
| Essential hypertension | D000075222 | — | I10 | 1 | — | 2 | — | — | 3 |
| Coronavirus infections | D018352 | EFO_0007224 | B34.2 | 1 | 2 | 1 | — | — | 2 |
| Respiratory insufficiency | D012131 | HP_0002093 | J96.9 | 1 | 2 | 1 | — | — | 2 |
| Sars-cov-2 | D000086402 | — | — | — | 2 | 2 | — | — | 2 |
| Hypertrophic cardiomyopathy | D002312 | EFO_0000538 | I42.1 | — | 2 | 1 | — | — | 2 |
| Chronic renal insufficiency | D051436 | — | N18 | 1 | — | 1 | — | — | 2 |
| Pneumonia | D011014 | EFO_0003106 | — | — | — | 1 | — | — | 1 |
| Coronavirus | D017934 | — | — | — | 1 | 1 | — | — | 1 |
Show 3 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hematologic neoplasms | D019337 | — | — | 1 | 3 | — | — | — | 4 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 2 | 1 | — | — | — | 3 |
| Hodgkin disease | D006689 | — | C81 | 2 | 1 | — | — | — | 3 |
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | — | 1 | — | — | 1 | 2 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | 1 | — | — | — | 2 |
| Multiple myeloma | D009101 | — | C90.0 | 1 | 1 | — | — | — | 2 |
| Anemia | D000740 | HP_0001903 | D64.9 | 1 | 1 | — | — | — | 2 |
| Cognitive dysfunction | D060825 | HP_0001268 | G31.84 | — | 2 | — | — | — | 2 |
| Psychological stress | D013315 | — | — | 1 | 2 | — | — | — | 2 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | 1 | 1 | — | — | — | 1 |
Show 23 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 7 | — | — | — | — | 7 |
| Myelodysplastic syndromes | D009190 | — | D46 | 3 | — | — | — | — | 3 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 2 | — | — | — | — | 2 |
| Primary myelofibrosis | D055728 | — | D47.4 | 2 | — | — | — | — | 2 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 2 | — | — | — | — | 2 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 2 | — | — | — | — | 2 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 2 | — | — | — | — | 2 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 2 | — | — | — | — | 2 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | 1 | — | — | — | 1 | 2 |
| Prostatic neoplasms | D011471 | — | C61 | 1 | — | — | — | — | 1 |
Show 24 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pre-eclampsia | D011225 | EFO_0000668 | O14 | — | — | — | — | 1 | 1 |
| Vascular diseases | D014652 | EFO_0004264 | I77 | — | — | — | — | 1 | 1 |
| Left ventricular hypertrophy | D017379 | EFO_0003896 | — | — | — | — | — | 1 | 1 |
| Hypophosphatemia | D017674 | HP_0002148 | — | — | — | — | — | 1 | 1 |
| Familial hypophosphatemic rickets | D053098 | — | — | — | — | — | — | 1 | 1 |
| Renin-angiotensin system | D012084 | — | — | — | — | — | — | 1 | 1 |
| Pediatric obesity | D063766 | — | — | — | — | — | — | 1 | 1 |
| Acute lung injury | D055371 | EFO_0004610 | — | — | — | — | — | 1 | 1 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | — | — | — | 1 | 1 |
| Hypoglycemia | D007003 | HP_0001943 | E16.2 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Txa127 |
| INN | — |
| Description | Ile(5)-angiotensin II (1-7) is an angiotensin compound consisting of the linear heptapeptide sequence L-Asp-L-Arg-L-Val-L-Tyr-L-Ile-L-His-L-Pro. It has a role as a vasodilator agent. It is a tautomer of an Ile(5)-angiotensin II (1-7) dizwitterion. |
| Classification | Protein |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 39386-80-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3545347 |
| ChEBI ID | 55438 |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | — |
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Safety
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Adverse Events
0 adverse events reported
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