Tucidinostat
Tucidinostat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against histone deacetylase 1.
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Commercial
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Clinical
Clinical Trials
236 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | 14 | 65 | 7 | 2 | 7 | 82 |
| T-cell lymphoma peripheral | D016411 | — | — | 11 | 43 | 8 | 3 | 7 | 62 |
| T-cell lymphoma | D016399 | — | — | 10 | 39 | 6 | 2 | 7 | 55 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 5 | 20 | 2 | 1 | 4 | 28 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | — | 21 | 2 | — | 3 | 26 |
| Leukemia | D007938 | — | C95 | 2 | 21 | 3 | — | 1 | 22 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 7 | 12 | 1 | — | — | 13 |
| Colorectal neoplasms | D015179 | — | — | 1 | 6 | 2 | — | 3 | 12 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 2 | 7 | 3 | — | — | 7 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 2 | 5 | 1 | — | 1 | 7 |
| Lymphoid leukemia | D007945 | — | C91 | — | 3 | 1 | — | — | 3 |
| Melanoma | D008545 | — | — | 1 | 1 | 1 | — | 1 | 3 |
| T-cell leukemia | D015458 | — | — | — | 2 | 2 | — | — | 2 |
| B-cell leukemia | D015448 | — | — | — | 1 | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| B-cell lymphoma | D016393 | — | — | — | 16 | — | — | 1 | 17 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 2 | 15 | — | — | 1 | 16 |
| Myeloid leukemia | D007951 | — | C92 | 1 | 12 | — | — | 1 | 13 |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | 7 | — | — | — | 7 |
| Triple negative breast neoplasms | D064726 | — | — | 1 | 5 | — | — | 1 | 6 |
| Immunoblastic lymphadenopathy | D007119 | EFO_1001350 | C86.5 | — | 5 | — | — | 1 | 6 |
| Recurrence | D012008 | — | — | 2 | 5 | — | — | — | 5 |
| Neoplasms | D009369 | — | C80 | 1 | 5 | — | — | — | 5 |
| Healthy volunteers/patients | — | — | — | 2 | 4 | — | — | — | 4 |
| Carcinoma | D002277 | — | C80.0 | 1 | 4 | — | — | — | 4 |
Show 46 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | 1 | — | — | — | — | 1 |
| Neuroblastoma | D009447 | EFO_0000621 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hemophagocytic lymphohistiocytosis | D051359 | — | D76.1 | — | — | — | — | 1 | 1 |
| Residual neoplasm | D018365 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Tucidinostat |
| INN | tucidinostat |
| Description | Chidamide is a member of benzamides. |
| Classification | Small molecule |
| Drug class | enzyme inhibitors: histone deacetylase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Nc1cc(F)ccc1NC(=O)c1ccc(CNC(=O)/C=C/c2cccnc2)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 743420-02-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3621988 |
| ChEBI ID | — |
| PubChem CID | 12136798 |
| DrugBank | DB06334 |
| UNII ID | 87CIC980Y0 (ChemIDplus, GSRS) |
Target
Agency Approved
HDAC1
HDAC1
Alternate
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Trends
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Safety
Black-box Warning
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Adverse Events
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234 adverse events reported
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