Tryptophan
Tryptophan is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against probable G-protein coupled receptor 139 and angiotensin-converting enzyme. In addition, it is known to target proton-coupled amino acid transporter 1, extracellular calcium-sensing receptor, proton-coupled amino acid transporter 2, hydroxycarboxylic acid receptor 3, sodium- and chloride-dependent neutral and basic amino acid transporter B(0+), receptor-interacting serine/threonine-protein kinase 1, and indoleamine 2,3-dioxygenase 1.
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EMA
Brand Name | Status | Last Update |
|---|---|---|
| aminosyn ii | New Drug Application | 2022-05-04 |
| aminosyn-pf | New Drug Application | 2022-07-21 |
| clinimix | New Drug Application | 2021-04-13 |
| clinimix e | New Drug Application | 2021-04-13 |
| clinisol | ANDA | 2018-06-01 |
| kabiven | New Drug Application | 2023-08-02 |
| perikabiven | New Drug Application | 2023-08-07 |
| plenamine | ANDA | 2023-04-21 |
| premasol - sulfite-free (amino acid) | ANDA | 2022-08-04 |
| prosol | New Drug Application | 2020-10-07 |
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146 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Syndrome | D013577 | — | — | — | — | 1 | 2 | 4 | 7 |
| Coronary artery disease | D003324 | — | I25.1 | — | 1 | — | 1 | 2 | 4 |
| Acute coronary syndrome | D054058 | EFO_0005672 | — | — | — | — | 3 | — | 3 |
| Chronic renal insufficiency | D051436 | — | N18 | — | — | — | 1 | 2 | 3 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | — | — | 1 | 2 | 3 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | — | — | — | 1 | 2 | 3 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | 1 | — | 1 | 1 | 3 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | — | — | — | 1 | 2 | 3 |
| Infarction | D007238 | EFO_0009463 | — | — | — | — | 1 | 1 | 2 |
| Heart valve diseases | D006349 | EFO_0009551 | I08 | — | 1 | — | 1 | — | 2 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 6 | 3 | 1 | — | — | 9 |
| Prostatic neoplasms | D011471 | — | C61 | — | 3 | 4 | — | — | 7 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 3 | 2 | 1 | — | 2 | 7 |
| Adenocarcinoma | D000230 | — | — | 1 | 1 | 3 | — | — | 4 |
| Neuroendocrine tumors | D018358 | EFO_1001901 | D3A.8 | 1 | 1 | 1 | — | 1 | 4 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | 2 | 1 | — | — | 3 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | 1 | 2 | 1 | — | 1 | 3 |
| Irritable bowel syndrome | D043183 | EFO_0000555 | K58 | — | — | 1 | — | 1 | 2 |
| Carcinoid tumor | D002276 | — | D3A.00 | — | 1 | 1 | — | — | 2 |
| Malignant carcinoid syndrome | D008303 | — | E34.0 | — | 1 | 1 | — | — | 2 |
Show 18 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 3 | 1 | — | — | 12 | 16 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 3 | 1 | — | — | 1 | 4 |
| Glioblastoma | D005909 | EFO_0000515 | — | 2 | 1 | — | — | 1 | 3 |
| Glioma | D005910 | EFO_0000520 | — | 2 | 2 | — | — | — | 3 |
| Melanoma | D008545 | — | — | 2 | 2 | — | — | — | 3 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | 1 | — | — | 2 | 3 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | 1 | — | — | 2 | 3 |
| Hypersensitivity | D006967 | HP_0012393 | T78.40 | — | 1 | — | — | 2 | 3 |
| Gliosarcoma | D018316 | — | — | 2 | 1 | — | — | — | 2 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 2 | 1 | — | — | — | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 1 | — | — | — | 3 | 4 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 2 | — | — | — | — | 2 |
| Affect | D000339 | — | — | 1 | — | — | — | 1 | 2 |
| Social behavior | D012919 | — | — | 2 | — | — | — | — | 2 |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | — | — | — | — | 1 |
| Medulloblastoma | D008527 | — | — | 1 | — | — | — | — | 1 |
| Ependymoma | D004806 | — | — | 1 | — | — | — | — | 1 |
| Diffuse intrinsic pontine glioma | D000080443 | — | — | 1 | — | — | — | — | 1 |
| Leukemia | D007938 | — | C95 | 1 | — | — | — | — | 1 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Depression | D003863 | — | F33.9 | — | — | — | — | 5 | 5 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | — | — | — | — | 4 | 4 |
| Myofascial pain syndromes | D009209 | EFO_1001054 | — | — | — | — | — | 3 | 3 |
| Fibromyalgia | D005356 | EFO_0005687 | M79.1 | — | — | — | — | 3 | 3 |
| Endocrine system diseases | D004700 | EFO_0001379 | E34.9 | — | — | — | — | 2 | 2 |
| Sleep | D012890 | GO_0030431 | — | — | — | — | — | 2 | 2 |
| Obstructive sleep apnea | D020181 | EFO_0003918 | G47.33 | — | — | — | — | 2 | 2 |
| Sleep apnea syndromes | D012891 | HP_0010535 | G47.3 | — | — | — | — | 2 | 2 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | — | — | — | 2 | 2 |
| Dyssomnias | D020920 | — | — | — | — | — | — | 2 | 2 |
Show 69 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Tryptophan |
| INN | tryptophan |
| Description | L-tryptophan is the L-enantiomer of tryptophan. It has a role as an antidepressant, a nutraceutical, a micronutrient, a plant metabolite, a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is an erythrose 4-phosphate/phosphoenolpyruvate family amino acid, a proteinogenic amino acid, a tryptophan and a L-alpha-amino acid. It is a conjugate base of a L-tryptophanium. It is a conjugate acid of a L-tryptophanate. It is an enantiomer of a D-tryptophan. It is a tautomer of a L-tryptophan zwitterion. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 73-22-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL54976 |
| ChEBI ID | 16828 |
| PubChem CID | 6305 |
| DrugBank | DB00150 |
| UNII ID | 8DUH1N11BX (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
SLC36A1
SLC36A1
Organism
Homo sapiens
Gene name
SLC36A1
Gene synonyms
PAT1
NCBI Gene ID
Protein name
proton-coupled amino acid transporter 1
Protein synonyms
lysosomal amino acid transporter 1, proton/amino acid transporter 1, solute carrier family 36 (proton/amino acid symporter), member 1, Solute carrier family 36 member 1
Uniprot ID
Mouse ortholog
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Safety
Black-box Warning
Black-box warning for: Aminosyn ii
Adverse Events
Top Adverse Reactions
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432 adverse events reported
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