Troxerutin
Troxerutin is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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| acacia pollen american beech american elm american sycamore arizona ash arizona cypress ash mixture aspen pollen australian pine austrian pine bald... | Biologic Licensing Application, Bulk ingredient | 2009-11-19 |
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812 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 11 | 1 | — | 1 | 33 | 46 |
| Inflammation | D007249 | MP_0001845 | — | 7 | 8 | 1 | 1 | 17 | 31 |
| Neoplasms | D009369 | — | C80 | 17 | 11 | — | 1 | 3 | 26 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 9 | 11 | 2 | 1 | 6 | 26 |
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | 4 | 8 | 1 | 2 | 5 | 19 |
| Prostatic neoplasms | D011471 | — | C61 | 5 | 11 | 1 | 1 | 2 | 18 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | 2 | 4 | — | 1 | 11 | 17 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 2 | 5 | 1 | 1 | 7 | 15 |
| Covid-19 | D000086382 | — | U07.1 | 1 | 3 | 1 | 2 | 7 | 14 |
| Hypertension | D006973 | EFO_0000537 | I10 | 2 | 1 | — | 2 | 7 | 12 |
Show 53 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Obesity | D009765 | EFO_0001073 | E66.9 | 1 | 7 | 2 | — | 16 | 25 |
| Cognitive dysfunction | D060825 | — | G31.84 | 2 | 8 | 1 | — | 14 | 22 |
| Metabolic syndrome | D024821 | EFO_0000195 | E88.810 | — | 4 | 2 | — | 15 | 19 |
| Coronary artery disease | D003324 | — | I25.1 | — | 2 | 2 | — | 9 | 12 |
| Hepatitis c | D006526 | — | B19.2 | 3 | 6 | 3 | — | 2 | 11 |
| Syndrome | D013577 | — | — | — | — | 2 | — | 6 | 8 |
| Melanoma | D008545 | — | — | 3 | 4 | 1 | — | 1 | 7 |
| Chronic hepatitis c | D019698 | EFO_0004220 | B18.2 | 3 | 4 | 1 | — | — | 7 |
| Weight loss | D015431 | — | — | 1 | 1 | 1 | — | 4 | 7 |
| Metabolic bone diseases | D001851 | — | — | — | 3 | 2 | — | 3 | 7 |
Show 55 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Replacement arthroplasty hip | D019644 | — | — | 1 | 1 | — | — | 16 | 18 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | 1 | 1 | — | — | 17 | 18 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 5 | 8 | — | — | 6 | 15 |
| Non-small-cell lung carcinoma | D002289 | — | — | 9 | 8 | — | — | 2 | 14 |
| Aging | D000375 | GO_0007568 | R41.81 | 1 | 3 | — | — | 10 | 13 |
| Overweight | D050177 | — | E66.3 | 2 | 1 | — | — | 9 | 12 |
| Coronary disease | D003327 | — | — | — | 1 | — | — | 8 | 9 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 5 | 4 | — | — | 1 | 8 |
| Frailty | D000073496 | — | R53.1 | — | 5 | — | — | 2 | 7 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | 2 | 2 | — | — | 4 | 7 |
Show 146 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Stroke | D020521 | EFO_0000712 | I63.9 | 1 | — | — | — | 4 | 5 |
| Prediabetic state | D011236 | EFO_1001121 | R73.03 | 2 | — | — | — | 2 | 4 |
| Joint diseases | D007592 | — | M12.9 | 1 | — | — | — | 3 | 4 |
| Glioblastoma | D005909 | EFO_0000515 | — | 2 | — | — | — | 1 | 3 |
| Dyslipidemias | D050171 | — | — | 1 | — | — | — | 2 | 3 |
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | 1 | — | — | — | 2 | 3 |
| Chemical and drug induced liver injury | D056486 | EFO_0004228 | — | 1 | — | — | — | 2 | 3 |
| Male breast neoplasms | D018567 | — | — | 2 | — | — | — | — | 2 |
| Polyneuropathies | D011115 | EFO_0009562 | A69.22 | 1 | — | — | — | 1 | 2 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 2 | — | — | — | — | 2 |
Show 43 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Fatigue | D005221 | — | R53.83 | — | — | — | — | 7 | 7 |
| Affect | D000339 | — | — | — | — | — | — | 7 | 7 |
| Necrosis | D009336 | — | — | — | — | — | — | 6 | 6 |
| Exercise | D015444 | EFO_0000483 | — | — | — | — | — | 5 | 5 |
| Neurodegenerative diseases | D019636 | EFO_0005772 | G31.9 | — | — | — | — | 5 | 5 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | — | — | — | — | 5 | 5 |
| Osteonecrosis | D010020 | EFO_0004259 | M87 | — | — | — | — | 4 | 4 |
| Postmenopausal osteoporosis | D015663 | EFO_0003854 | — | — | — | — | — | 3 | 3 |
| Inflammatory bowel diseases | D015212 | EFO_0003767 | — | — | — | — | — | 3 | 3 |
| Hypersensitivity | D006967 | EFO_0003785 | T78.40 | — | — | — | — | 3 | 3 |
Show 181 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Troxerutin |
| INN | troxerutin |
| Description | Troxerutin is a flavonol, a type of flavonoid, derived from rutin. It is more accurately a hydroxyethylrutoside. It can be isolated from Sophora japonica, the Japanese pagoda tree.
|
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@@H]1O[C@@H](OC[C@H]2O[C@@H](Oc3c(-c4ccc(OCCO)c(OCCO)c4)oc4cc(OCCO)cc(O)c4c3=O)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL3182320 |
| ChEBI ID | — |
| PubChem CID | 9896814 |
| DrugBank | — |
| UNII ID | 7Y4N11PXO8 (ChemIDplus, GSRS) |
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Recothrom – Bristol Myers Squibb
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Additional graphs summarizing 181,088 documents
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Safety
Black-box Warning
Black-box warning for: Acacia pollen american beech american elm american sycamore arizona ash arizona cypress ash mixture aspen pollen australian pine austrian pine bald..., Alfalfa pollen allscale annual saltbush atriplex mixture bitter dock burweed marsh elder careless weed chenopodium mixture coastal sage cocklebur c..., Aminosyn ii, Enlyte
Adverse Events
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152,285 adverse events reported
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