Trospium
Cobenfy, Trospium (trospium) is a small molecule pharmaceutical. Trospium was first approved as Sanctura on 2004-05-28. It is used to treat overactive urinary bladder and urge urinary incontinence in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| urogenital diseases | D000091642 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Trospium (discontinued: Sanctura, Trospium)
CombinationsCobenfy
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Trospium chloride
Trospium chloride
+
Xanomeline tartrate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| COBENFY | Bristol Myers Squibb | N-216158 RX | 2024-09-26 | 3 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| cobenfy | New Drug Application | 2024-09-30 |
| trospium chloride | ANDA | 2024-10-30 |
| trospium chloride er | ANDA | 2023-01-31 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| overactive urinary bladder | EFO_1000781 | D053201 | N32.81 |
| urge urinary incontinence | EFO_0006865 | D053202 | N39.41 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A03: Drugs for functional gastrointestinal disorders
— A03D: Antispasmodics in combination with analgesics
— A03DA: Synthetic anticholinergic agents in combination with analgesics
— A03DA06: Trospium and analgesics
G: Genito urinary system and sex hormones
— G04: Urologicals
— G04B: Urologicals
— G04BD: Drugs for urinary frequency and incontinence
— G04BD09: Trospium
HCPCS
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Clinical
Clinical Trials
40 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Overactive urinary bladder | D053201 | EFO_1000781 | N32.81 | 3 | — | 1 | 7 | 6 | 17 |
| Urinary incontinence | D014549 | HP_0000020 | R32 | 2 | — | 1 | 4 | — | 7 |
| Enuresis | D004775 | — | R32 | 2 | — | 1 | 3 | — | 6 |
| Urge urinary incontinence | D053202 | EFO_0006865 | N39.41 | — | — | 1 | 1 | — | 2 |
| Spinal cord injuries | D013119 | EFO_1001919 | — | 1 | — | — | 1 | — | 2 |
| Pharmacokinetics | D010599 | — | — | 1 | — | — | 1 | — | 2 |
| Inflammation | D007249 | MP_0001845 | — | — | — | — | 1 | — | 1 |
| Cognition | D003071 | EFO_0003925 | — | — | — | — | 1 | — | 1 |
| Mental competency | D016743 | — | — | — | — | — | 1 | — | 1 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Schizophrenia | D012559 | EFO_0000692 | F20 | 1 | 1 | 8 | — | — | 10 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | — | — | 3 | — | — | 3 |
| Psychotic disorders | D011618 | — | F20.81 | — | — | 3 | — | — | 3 |
| Mental disorders | D001523 | EFO_0000677 | F91.9 | — | — | 3 | — | — | 3 |
| Interstitial cystitis | D018856 | EFO_1000869 | N30.1 | — | — | 1 | — | — | 1 |
| Pelvic pain | D017699 | — | — | — | — | 1 | — | — | 1 |
| Cystitis | D003556 | EFO_1000025 | N30 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | 1 | 2 | — | — | — | 2 |
| Lung diseases | D008171 | HP_0002088 | J98.4 | 1 | 2 | — | — | — | 2 |
| Obstructive lung diseases | D008173 | HP_0006536 | — | 1 | 2 | — | — | — | 2 |
| Respiratory aspiration | D053120 | EFO_1001839 | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | — | 2 |
| Drug interactions | D004347 | — | — | 1 | — | — | — | — | 1 |
| Accidental injuries | D000081084 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Urologic diseases | D014570 | — | N39.9 | — | — | — | — | 1 | 1 |
| Urinary bladder diseases | D001745 | — | N32.9 | — | — | — | — | 1 | 1 |
| Ureterolithiasis | D053039 | EFO_1001228 | N20.1 | — | — | — | — | 1 | 1 |
| Ureteral obstruction | D014517 | HP_0006000 | — | — | — | — | — | 1 | 1 |
| Deprescriptions | D000069340 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Trospium |
| INN | trospium chloride |
| Description | Trospium chloride is a muscarinic antagonist used to treat overactive bladder. It has side effects typical of this class of drugs, namely dry mouth, stomach upset, and constipation; these side effects cause problems with people taking their medicine as directed. However it doesn't cause central nervous system side effects like some other muscarinic antagonists. It is in pregnancy category C and is excreted in breast milk.
|
| Classification | Small molecule |
| Drug class | quaternary ammonium derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1 |
Identifiers
| PDB | — |
| CAS-ID | 47608-32-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1888176 |
| ChEBI ID | — |
| PubChem CID | 107979 |
| DrugBank | DB00209 |
| UNII ID | 1E6682427E (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Estimated US medical usage
Trospium
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 922 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,586 adverse events reported
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