Troriluzole
Troriluzole is a protein pharmaceutical. It is currently being investigated in clinical studies.
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Events Timeline
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Commercial
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Clinical
Clinical Trials
14 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Obsessive-compulsive disorder | D009771 | EFO_0004242 | F42 | — | 1 | 4 | — | — | 4 |
| Compulsive personality disorder | D003193 | — | F60.5 | — | 1 | 4 | — | — | 4 |
| Ataxia | D001259 | — | R27.0 | — | 1 | 2 | — | 2 | 4 |
| Spinocerebellar degenerations | D013132 | — | G11 | — | 1 | 2 | — | 2 | 4 |
| Spinocerebellar ataxias | D020754 | — | — | — | 1 | 2 | — | 2 | 4 |
| Cerebellar ataxia | D002524 | — | — | — | 1 | 2 | — | 2 | 4 |
| Glioblastoma | D005909 | EFO_0000515 | — | 1 | 1 | 1 | — | — | 2 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | — | — | 1 | — | — | 1 |
| Generalized anxiety disorder | D000098647 | — | — | — | — | 1 | — | — | 1 |
| Machado-joseph disease | D017827 | EFO_0004135 | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Melanoma | D008545 | — | — | 1 | 1 | — | — | — | 2 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Recurrence | D012008 | — | — | 2 | — | — | — | — | 2 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 1 | — | — | — | — | 1 |
| Carcinoma | D002277 | — | C80.0 | 1 | — | — | — | — | 1 |
| Neoplasms | D009369 | — | C80 | 1 | — | — | — | — | 1 |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | — | — | — | — | 1 |
| Lung neoplasms | D008175 | — | C34.90 | 1 | — | — | — | — | 1 |
| Lymphoma | D008223 | — | C85.9 | 1 | — | — | — | — | 1 |
| Urinary bladder neoplasms | D001749 | — | C67 | 1 | — | — | — | — | 1 |
| Skin neoplasms | D012878 | EFO_0004198 | C44 | 1 | — | — | — | — | 1 |
| Hodgkin disease | D006689 | — | C81 | 1 | — | — | — | — | 1 |
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Troriluzole |
| INN | troriluzole |
| Description | Troriluzole (trigriluzole) is an experimental medication that has been investigated as a potential treatment for spinocerebellar ataxia type 3 (SCA3), obsessive-compulsive disorder, and glioblastoma. It is a prodrug formulation of the medication riluzole.
|
| Classification | Protein |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN(CC(=O)Nc1nc2ccc(OC(F)(F)F)cc2s1)C(=O)CNC(=O)CN |
Identifiers
| PDB | — |
| CAS-ID | 1926203-09-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297586 |
| ChEBI ID | — |
| PubChem CID | 121488186 |
| DrugBank | DB15079 |
| UNII ID | S7H48S6K7H (ChemIDplus, GSRS) |
Target
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Variants
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Trends
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Safety
Black-box Warning
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Adverse Events
0 adverse events reported
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