Tropisetron
Tropisetron is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target glycine receptor subunit alpha-2, 5-hydroxytryptamine receptor 4, glycine receptor subunit beta, and glycine receptor subunit alpha-1.
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Clinical Trials
42 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vomiting | D014839 | — | R11.1 | — | 3 | 5 | 6 | 6 | 20 |
| Nausea | D009325 | — | R11.0 | — | 3 | 4 | 3 | 5 | 15 |
| Postoperative nausea and vomiting | D020250 | EFO_0004888 | — | — | — | — | 1 | 3 | 4 |
| Pain | D010146 | EFO_0003843 | R52 | — | 1 | — | 1 | 1 | 3 |
| Neoplasms | D009369 | — | C80 | — | 1 | — | 1 | — | 2 |
| Postoperative pain | D010149 | — | G89.18 | — | — | — | 2 | — | 2 |
| Delirium | D003693 | — | R41.0 | — | — | — | 2 | — | 2 |
| Emergence delirium | D000071257 | — | — | — | — | — | 2 | — | 2 |
| Lung neoplasms | D008175 | — | C34.90 | — | — | — | 1 | — | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Electroacupuncture | D015671 | — | — | — | — | 2 | — | 1 | 3 |
| Colorectal neoplasms | D015179 | — | — | — | — | 1 | — | — | 1 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | — | 1 | — | — | 1 |
| Smoking cessation | D016540 | EFO_0004319 | — | — | — | 1 | — | — | 1 |
| Nasopharyngeal carcinoma | D000077274 | — | — | — | — | 1 | — | — | 1 |
| Uterine cervical neoplasms | D002583 | — | — | — | — | 1 | — | — | 1 |
| Nasopharyngeal neoplasms | D009303 | — | — | — | — | 1 | — | — | 1 |
| Syndrome | D013577 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart valve diseases | D006349 | EFO_0009551 | I08 | — | 1 | — | — | — | 1 |
| Small cell lung carcinoma | D055752 | — | — | 1 | 1 | — | — | — | 1 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | — | 1 | — | — | — | 1 |
| Chronic disease | D002908 | — | — | — | 1 | — | — | — | 1 |
| Hypersensitivity | D006967 | EFO_0003785 | T78.40 | — | 1 | — | — | — | 1 |
| Musculoskeletal pain | D059352 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Agnosia | D000377 | EFO_0007136 | F88 | — | — | — | — | 2 | 2 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | — | — | — | — | 1 | 1 |
| Lymphoma | D008223 | — | C85.9 | — | — | — | — | 1 | 1 |
| Anesthesia and analgesia | D000760 | — | — | — | — | — | — | 1 | 1 |
| Hepatectomy | D006498 | — | — | — | — | — | — | 1 | 1 |
| Analgesia | D000698 | — | — | — | — | — | — | 1 | 1 |
| Cardiac surgical procedures | D006348 | — | — | — | — | — | — | 1 | 1 |
| Nerve block | D009407 | — | — | — | — | — | — | 1 | 1 |
| Laparoscopic cholecystectomy | D017081 | — | — | — | — | — | — | 1 | 1 |
| Pain management | D059408 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Tropisetron |
| INN | tropisetron |
| Description | Tropisetron is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic to treat nausea and vomiting following chemotherapy, although it has been used experimentally as an analgesic in cases of fibromyalgia.
|
| Classification | Small molecule |
| Drug class | serotonin 5-HT3 receptor antagonists; atropine derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)c1c[nH]c3ccccc13)C2 |
Identifiers
| PDB | — |
| CAS-ID | 89565-68-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL56564 |
| ChEBI ID | 32269 |
| PubChem CID | 72165 |
| DrugBank | DB11699 |
| UNII ID | 6I819NIK1W (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
GLRA2
GLRA2
HTR4
HTR4
GLRB
GLRB
GLRA1
GLRA1
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Safety
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131 adverse events reported
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