Tropisetron
Tropisetron is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target glycine receptor subunit alpha-2, 5-hydroxytryptamine receptor 4, glycine receptor subunit beta, and glycine receptor subunit alpha-1.
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Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lung neoplasms | D008175 | — | C34.90 | 1 | 1 | — | — | — | 1 |
| Small cell lung carcinoma | D055752 | — | — | 1 | 1 | — | — | — | 1 |
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Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Tropisetron |
| INN | tropisetron |
| Description | Tropisetron is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic to treat nausea and vomiting following chemotherapy, although it has been used experimentally as an analgesic in cases of fibromyalgia.
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| Classification | Small molecule |
| Drug class | serotonin 5-HT3 receptor antagonists; atropine derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)c1c[nH]c3ccccc13)C2 |
Identifiers
| PDB | — |
| CAS-ID | 89565-68-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL56564 |
| ChEBI ID | 32269 |
| PubChem CID | 72165 |
| DrugBank | DB11699 |
| UNII ID | 6I819NIK1W (ChemIDplus, GSRS) |
Target
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GLRA2
GLRA2
HTR4
HTR4
GLRB
GLRB
GLRA1
GLRA1
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127 adverse events reported
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