Triprolidine
Actahist, Actidil, Actifed, Allerfed, Corphed, Histafed, Myfed, Myidyl, Triacin-c, Trilitron, Triphed (triprolidine) is a small molecule pharmaceutical. Triprolidine was first approved as Triprolidine hydrochloride on 1982-01-01. It is used to treat allergic conjunctivitis, atopic dermatitis, and rhinitis in the USA. The pharmaceutical is active against histamine H1 receptor.
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Triprolidine hydrochloride
Codeine phosphate
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Pseudoephedrine hydrochloride
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Triprolidine hydrochloride
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| actifed | C200263 | 2024-10-04 |
| aprodine | C200263 | 2025-04-22 |
| childrens pediaclear pd | C200263 | 2025-10-03 |
| cold and allergy d | C200263 | 2025-02-05 |
| cold and flu | C200263 | 2025-08-19 |
| cvs maximum strength severe congestion and cough | OTC monograph final | 2020-04-13 |
| cvs mucus relief dm and overnight cold and flu | C200263 | 2024-08-20 |
| cvs nighttime cold and flu | C200263 | 2024-08-20 |
| cvs overnight cold and flu clear and cool | C200263 | 2024-08-20 |
| day cold and flu and night severe cold and flu | C200263 | 2024-08-22 |
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8 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart failure | D006333 | EFO_0003144 | I50 | — | — | 1 | — | 3 | 4 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Rhinitis | D012220 | EFO_0008521 | J31 | — | 1 | — | — | — | 1 |
| Allergic rhinitis seasonal | D006255 | EFO_0003956 | J30 | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Meibomian gland dysfunction | D000080343 | — | H02.88 | — | — | — | — | 1 | 1 |
| Blepharitis | D001762 | EFO_0009536 | H01.0 | — | — | — | — | 1 | 1 |
| Breast cancer lymphedema | D000072656 | — | — | — | — | — | — | 1 | 1 |
| Lymphedema | D008209 | — | Q82.0 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Triprolidine |
| INN | triprolidine |
| Description | Triprolidine is an N-alkylpyrrolidine that is acrivastine in which the pyridine ring is lacking the propenoic acid substituent. It is a sedating antihistamine that is used (generally as the monohydrochloride monohydrate) for the relief of the symptoms of uticaria, rhinitis, and various pruritic skin disorders. It has a role as a H1-receptor antagonist. It is a N-alkylpyrrolidine, a member of pyridines and an olefinic compound. It is a conjugate base of a triprolidine(1+). |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1ccc(/C(=C\CN2CCCC2)c2ccccn2)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 486-12-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL855 |
| ChEBI ID | 84116 |
| PubChem CID | 5282443 |
| DrugBank | DB00427 |
| UNII ID | 2L8T9S52QM (ChemIDplus, GSRS) |
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Estimated US medical usage
Triprolidine
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Phenylephrine
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Codeine
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Triprolidine
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Dextromethorphan
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Phenylephrine
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Triprolidine
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Pseudoephedrine
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Triprolidine
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Additional graphs summarizing 774 documents
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Safety
Black-box Warning
Black-box warning for: Triacin-c
Adverse Events
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1,084 adverse events reported
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