Trimethoprim
/ Trimethoprim, Bactrim, Primsol, Septra, Sulfatrim, Trimethoprim (trimethoprim) is a small molecule pharmaceutical. Trimethoprim was first approved as Septra on 1982-01-01. It is used to treat aids-related opportunistic infections, bacterial eye infections, bacterial infections, bronchitis, and escherichia coli infections amongst others in the USA.
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Commercial
Therapeutic Areas
Trade Name
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Combinations
Bactrim, Septra, Sulfatrim (generic drugs available since 1985-06-06, discontinued: Cotrim, Cotrim d.s, Polytrim, Septra grape, Sulfamethoprim, Sulfatrim-ss, Sulmeprim, Trimeth/sulfa, Uroplus, Uroplus ss)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Phenazopyridine hydrochloride
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Sulfamethoxazole
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Trimethoprim
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| SULFAMETHOXAZOLE AND TRIMETHOPRIM AND PHENAZOPYRIDINE HYDROCHLORIDE | Able Laboratories | N-021105 DISCN | 2001-06-26 | 1 products |
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Polymyxin b sulfate
+
Trimethoprim sulfate
Sulfamethoxazole
+
Trimethoprim
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| SEPTRA | Monarch Pharmaceuticals | N-017376 RX | 1982-01-01 | 1 products |
| SEPTRA DS | Monarch Pharmaceuticals | N-017376 RX | 1982-01-01 | 1 products |
| SULFATRIM PEDIATRIC | PAI Pharma | N-018615 RX | 1983-01-07 | 1 products |
| BACTRIM | Sun Pharmaceutical Industries | N-017377 RX | 1982-01-01 | 1 products, RLD |
| BACTRIM DS | Sun Pharmaceutical Industries | N-017377 RX | 1982-01-01 | 1 products, RLD, RS |
Show 14 discontinued
Trimethoprim
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| TRIMETHOPRIM | Dr Reddys Laboratories | N-018679 RX | 1982-07-30 | 1 products, RLD, RS |
Show 3 discontinued
Trimethoprim hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| PRIMSOL | Allegis Pharmaceuticals | N-074374 DISCN | 1995-06-23 | 1 products |
| PRIMSOL | Allegis Pharmaceuticals | N-074973 DISCN | 2000-01-24 | 1 products, RLD |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| bactrim bactrim ds | New Drug Application | 2024-07-02 |
| bactrim ds | New Drug Application | 2024-07-25 |
| polymyxin b sulfate and trimethoprim | ANDA | 2024-07-30 |
| polymyxin b sulfate and trimethoprim sulfate | NDA authorized generic | 2024-08-15 |
| sulfamethox-tmp ds | ANDA | 2022-10-09 |
| sulfamethoxazole and trimethoprim | ANDA | 2024-09-09 |
| sulfamethoxazole and trimethoprim ds | ANDA | 2010-04-28 |
| sulfamethoxazole, and trimethoprim | ANDA | 2009-10-09 |
| sulfatrim | New Drug Application | 2024-07-24 |
| trimethoprim | New Drug Application | 2024-01-26 |
Show 1 more
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Agency Specific
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Patent Expiration
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ATC Codes
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01E: Sulfonamides and trimethoprim antibacterials for systemic use
— J01EA: Trimethoprim and derivatives, systemic antibacterials
— J01EA01: Trimethoprim
— J01EE: Combinations of sulfonamides and trimethoprim, incl. derivatives
— J01EE01: Sulfamethoxazole and trimethoprim
— J01EE02: Sulfadiazine and trimethoprim
— J01EE03: Sulfametrole and trimethoprim
— J01EE04: Sulfamoxole and trimethoprim
— J01EE05: Sulfadimidine and trimethoprim
— J01EE07: Sulfamerazine and trimethoprim
— J01R: Combinations of antibacterials
— J01RA: Combinations of antibacterials
— J01RA02: Sulfonamides, combinations with other antibacterials (excl. trimethoprim)
— J04: Antimycobacterials
— J04A: Drugs for treatment of tuberculosis
— J04AM: Combinations of drugs for treatment of tuberculosis
— J04AM08: Isoniazid, sulfamethoxazole, trimethoprim and pyridoxine
HCPCS
Code | Description |
|---|---|
| S0039 | Injection, sulfamethoxazole and trimethoprim, 10 ml |
Clinical
Clinical Trials
300 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | 3 | 18 | 18 | 21 | 21 | 76 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 4 | 8 | 22 | 6 | 17 | 54 |
| Communicable diseases | D003141 | — | — | 2 | 9 | 13 | 15 | 16 | 53 |
| Pneumonia | D011014 | EFO_0003106 | — | 2 | 7 | 21 | 7 | 12 | 46 |
| Urinary tract infections | D014552 | EFO_0003103 | N39.0 | 1 | 9 | 6 | 14 | 13 | 41 |
| Pneumocystis pneumonia | D011020 | EFO_0007448 | B59 | 3 | 7 | 16 | 5 | 7 | 35 |
| Malaria | D008288 | EFO_0001068 | B54 | — | 2 | 10 | 2 | 5 | 19 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | — | 1 | 4 | 4 | 6 | 15 |
| Hiv | D006678 | — | — | — | 1 | 3 | 3 | 7 | 14 |
| Abscess | D000038 | EFO_0003030 | — | — | — | 2 | 2 | 6 | 10 |
Show 77 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Staphylococcal infections | D013203 | — | A49.01 | — | 5 | 5 | — | 6 | 15 |
| Bacterial infections | D001424 | — | A49 | 5 | 1 | 1 | — | 2 | 9 |
| Multiple myeloma | D009101 | — | C90.0 | 2 | 5 | 1 | — | — | 7 |
| Plasma cell neoplasms | D054219 | — | — | 2 | 5 | 1 | — | — | 7 |
| Sepsis | D018805 | HP_0100806 | A41.9 | — | 1 | 3 | — | 3 | 7 |
| Syndrome | D013577 | — | — | 2 | 2 | 1 | — | 1 | 5 |
| Neoplasms | D009369 | — | C80 | 3 | 2 | 1 | — | — | 4 |
| Fibrosis | D005355 | — | — | — | 2 | 2 | — | — | 4 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 2 | 2 | 1 | — | 1 | 4 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | — | — | 1 | — | 2 | 3 |
Show 45 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Staphylococcus aureus | D013211 | NCBITaxon_1280 | — | — | 2 | — | — | 4 | 6 |
| Lymphoma | D008223 | — | C85.9 | 1 | 4 | — | — | 1 | 5 |
| Leukemia | D007938 | — | C95 | 3 | 3 | — | — | — | 4 |
| Infectious arthritis | D001170 | EFO_1001351 | M00 | — | 1 | — | — | 2 | 3 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | — | 2 | 2 | — | — | — | 3 |
| Lymphoid leukemia | D007945 | — | C91 | 2 | 2 | — | — | — | 3 |
| Cellulitis | D002481 | EFO_0003035 | L03.90 | — | 1 | — | — | 2 | 3 |
| Cystic fibrosis | D003550 | EFO_0000390 | E84 | — | 3 | — | — | — | 3 |
| Disease progression | D018450 | — | — | 1 | 1 | — | — | 2 | 3 |
| Sinusitis | D012852 | EFO_0007486 | J32 | — | 1 | — | — | 1 | 2 |
Show 26 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prosthesis-related infections | D016459 | EFO_1001406 | — | 1 | — | — | — | 2 | 3 |
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | — | 2 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | 1 | — | — | — | — | 1 |
| Congenital microtia | D065817 | — | Q16.0 | 1 | — | — | — | — | 1 |
| Oxidative stress | D018384 | EFO_1001905 | — | 1 | — | — | — | — | 1 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 1 | — | — | — | — | 1 |
| Glioblastoma | D005909 | EFO_0000515 | — | 1 | — | — | — | — | 1 |
| Astrocytoma | D001254 | EFO_0000271 | — | 1 | — | — | — | — | 1 |
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | 1 | — | — | — | — | 1 |
| Geographic atrophy | D057092 | — | — | 1 | — | — | — | — | 1 |
Show 9 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bronchitis | D001991 | — | J40 | — | — | — | — | 3 | 3 |
| Hypospadias | D007021 | EFO_0004209 | Q54 | — | — | — | — | 3 | 3 |
| Ulcer | D014456 | MPATH_579 | — | — | — | — | — | 2 | 2 |
| Surgical wound infection | D013530 | — | — | — | — | — | — | 2 | 2 |
| Aortic dissection | D000784 | — | I71.0 | — | — | — | — | 1 | 1 |
| Death | D003643 | PATO_0001422 | — | — | — | — | — | 1 | 1 |
| Long qt syndrome | D008133 | HP_0001657 | I45.81 | — | — | — | — | 1 | 1 |
| Delirium | D003693 | — | R41.0 | — | — | — | — | 1 | 1 |
| Torsades de pointes | D016171 | EFO_0005307 | I47.21 | — | — | — | — | 1 | 1 |
| Whooping cough | D014917 | EFO_0000650 | A37.0 | — | — | — | — | 1 | 1 |
Show 40 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Trimethoprim |
| INN | trimethoprim |
| Description | Trimethoprim is an aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge. It has a role as an EC 1.5.1.3 (dihydrofolate reductase) inhibitor, a xenobiotic, an environmental contaminant, a drug allergen, an antibacterial drug and a diuretic. It is a member of methoxybenzenes and an aminopyrimidine. |
| Classification | Small molecule |
| Drug class | antibacterials (trimethoprim type), dihydrofolate reductase (DHFR) inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC |
Identifiers
| PDB | — |
| CAS-ID | 738-70-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL22 |
| ChEBI ID | 45924 |
| PubChem CID | 5578 |
| DrugBank | DB00440 |
| UNII ID | AN164J8Y0X (ChemIDplus, GSRS) |
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Trimethoprim
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Polymyxin b
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Trimethoprim
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Sulfamethoxazole
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Trimethoprim
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Safety
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48,667 adverse events reported
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