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AboutPricing
Drug ReportsTrimethoprim
Trimethoprim
/ Trimethoprim, Bactrim, Primsol, Septra, Sulfatrim, Trimethoprim (trimethoprim) is a small molecule pharmaceutical. Trimethoprim was first approved as Septra on 1982-01-01. It is used to treat aids-related opportunistic infections, bacterial eye infections, bacterial infections, bronchitis, and escherichia coli infections amongst others in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
respiratory tract diseasesD012140
eye diseasesD005128
urogenital diseasesD000091642
immune system diseasesD007154
Trade Name
FDA
EMA
Trimethoprim (discontinued: Primsol, Proloprim, Trimethoprim, Trimpex)
Combinations
Bactrim, Septra, Sulfamethoxazole trimethoprim, Sulfatrim, Trimethoprim polymyxin b (discontinued: Bactrim, Cotrim, Cotrim d.s, Polytrim, Septra, Septra grape, Sulfamethoxazole trimethoprim, Sulfamethoxazole trimethoprim phenazopyridine, Sulfatrim, Sulfatrim-ss, Trimeth/sulfa, Uroplus, Uroplus ss)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Sulfamethoxazole
+
Trimethoprim
Tradename
Company
Number
Date
Products
SEPTRAMonarch PharmaceuticalsN-017376 RX1982-01-01
1 products
SEPTRA DSMonarch PharmaceuticalsN-017376 RX1982-01-01
1 products
SULFATRIM PEDIATRICPAI PharmaN-018615 RX1983-01-07
1 products
BACTRIMSun Pharmaceutical IndustriesN-017377 RX1982-01-01
1 products, RLD
BACTRIM DSSun Pharmaceutical IndustriesN-017377 RX1982-01-01
1 products, RLD, RS
Show 14 discontinued
Trimethoprim
Tradename
Company
Number
Date
Products
TRIMETHOPRIMDr Reddys LaboratoriesN-018679 RX1982-07-30
1 products, RLD, RS
Show 3 discontinued
Polymyxin b sulfate
+
Trimethoprim sulfate
Tradename
Company
Number
Date
Products
POLYTRIMAllerganN-050567 DISCN1988-10-20
1 products, RLD
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Phenazopyridine hydrochloride
+
Sulfamethoxazole
+
Trimethoprim
Tradename
Company
Number
Date
Products
SULFAMETHOXAZOLE AND TRIMETHOPRIM AND PHENAZOPYRIDINE HYDROCHLORIDEAble LaboratoriesN-021105 DISCN2001-06-26
1 products
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Trimethoprim hydrochloride
Tradename
Company
Number
Date
Products
PRIMSOLAllegis PharmaceuticalsN-074374 DISCN1995-06-23
1 products
PRIMSOLAllegis PharmaceuticalsN-074973 DISCN2000-01-24
1 products, RLD
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
bactrim bactrim dsNew Drug Application2024-12-30
bactrim dsNew Drug Application2024-07-25
polymyxin b sulfate and trimethoprimANDA2025-02-25
polymyxin b sulfate and trimethoprim sulfateNDA authorized generic2024-08-15
ss-tmpflOTC monograph not final2020-03-08
sulfamethox-tmp dsANDA2022-10-09
sulfamethoxazole and trimethoprimANDA2025-04-03
sulfamethoxazole and trimethoprim dsANDA2010-04-28
sulfamethoxazole, and trimethoprimANDA2009-10-09
sulfatrimNew Drug Application2025-03-06
Show 2 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
mycoses—D009181B35-B49
toxoplasmosisEFO_0007517D014123B58
urinary tract infectionsEFO_0003103D014552N39.0
chronic bronchitis—D029481J42
otitis mediaEFO_0004992D010033H66.9
bacterial infections—D001424A49
enterobacteriaceae infectionsEFO_1001313D004756—
escherichia coli infectionsEFO_1001318D004927B96.20
bronchitis—D001991J40
bacterial eye infections—D015818—
Show 20 more
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01E: Sulfonamides and trimethoprim antibacterials for systemic use
— J01EA: Trimethoprim and derivatives, systemic antibacterials
— J01EA01: Trimethoprim
— J01EE: Combinations of sulfonamides and trimethoprim, incl. derivatives
— J01EE01: Sulfamethoxazole and trimethoprim
— J01EE02: Sulfadiazine and trimethoprim
— J01EE03: Sulfametrole and trimethoprim
— J01EE04: Sulfamoxole and trimethoprim
— J01EE05: Sulfadimidine and trimethoprim
— J01EE07: Sulfamerazine and trimethoprim
— J01R: Combinations of antibacterials
— J01RA: Combinations of antibacterials
— J01RA02: Sulfonamides, combinations with other antibacterials (excl. trimethoprim)
— J04: Antimycobacterials
— J04A: Drugs for treatment of tuberculosis
— J04AM: Combinations of drugs for treatment of tuberculosis
— J04AM08: Isoniazid, sulfamethoxazole, trimethoprim and pyridoxine
HCPCS
Code
Description
S0039
Injection, sulfamethoxazole and trimethoprim, 10 ml
Clinical
Clinical Trials
290 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Lacrimal duct obstructionD007767——1————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTrimethoprim
INNtrimethoprim
Description
Trimethoprim is an aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge. It has a role as an EC 1.5.1.3 (dihydrofolate reductase) inhibitor, a xenobiotic, an environmental contaminant, a drug allergen, an antibacterial drug and a diuretic. It is a member of methoxybenzenes and an aminopyrimidine.
Classification
Small molecule
Drug classantibacterials (trimethoprim type), dihydrofolate reductase (DHFR) inhibitors
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC
Identifiers
PDB—
CAS-ID738-70-5
RxCUI—
ChEMBL IDCHEMBL22
ChEBI ID45924
PubChem CID5578
DrugBankDB00440
UNII IDAN164J8Y0X (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Trimethoprim
+
Polymyxin b
Total medical expenditures per year (USD, in millions)
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Trimethoprim
+
Sulfamethoxazole
Total medical expenditures per year (USD, in millions)
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Trimethoprim
Total medical expenditures per year (USD, in millions)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 84,946 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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47,452 adverse events reported
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