Trilaciclib
Cosela (trilaciclib) is a small molecule pharmaceutical. Trilaciclib was first approved as Cosela on 2021-02-12. It is known to target cyclin-dependent kinase 4, cyclin-dependent kinase 6, cyclin-dependent kinase 7, cyclin-dependent kinase 9, and cyclin-dependent kinase 2.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
Cosela
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Trilaciclib dihydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| COSELA | Pharmacosmos | N-214200 RX | 2021-02-12 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| cosela | New Drug Application | 2025-08-31 |
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
TRILACICLIB DIHYDROCHLORIDE, COSELA, G1 THERAP | |||
| 2026-02-12 | NCE | ||
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Trilaciclib Dihydrochloride, Cosela, G1 Therap | |||
| 11529352 | 2039-07-23 | U-3504 | |
| 9487530 | 2034-03-14 | U-3079, U-3080 | |
| 10085992 | 2034-03-14 | U-3081 | |
| 10966984 | 2034-03-14 | U-3079, U-3080 | |
| 11040042 | 2034-03-14 | DP | |
| 11717523 | 2034-03-14 | U-3678, U-3679 | |
| 8598186 | 2031-10-25 | DS, DP | |
| 8598197 | 2031-10-25 | DS, DP | |
| 9957276 | 2031-10-25 | DP | |
| 10189849 | 2031-10-25 | DP | |
| 10189850 | 2031-10-25 | DP | |
| 10927120 | 2031-10-25 | DP | |
HCPCS
Code | Description |
|---|---|
| J1448 | Injection, trilaciclib, 1mg |
Clinical
Clinical Trials
42 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Small cell lung carcinoma | D055752 | — | — | 2 | 5 | 1 | 2 | 1 | 9 |
| Lung neoplasms | D008175 | — | C34.90 | — | 5 | 1 | 1 | 1 | 8 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 9 | 1 | — | — | 10 |
| Triple negative breast neoplasms | D064726 | — | — | — | 6 | 1 | — | — | 7 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | 3 | 1 | — | — | 4 |
| Urinary bladder neoplasms | D001749 | — | C67 | — | 1 | 1 | — | — | 2 |
| Colorectal neoplasms | D015179 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | — | 9 | — | — | — | 9 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | — | 3 | — | — | — | 3 |
| Squamous cell carcinoma | D002294 | — | — | — | 2 | — | — | 1 | 3 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | 2 | — | — | — | 2 |
| Osteosarcoma | D012516 | — | — | — | 2 | — | — | — | 2 |
| Carcinoma | D002277 | — | C80.0 | — | 2 | — | — | — | 2 |
| Hemangiosarcoma | D006394 | — | — | — | 1 | — | — | — | 1 |
| Urologic neoplasms | D014571 | — | C64-C68 | — | 1 | — | — | — | 1 |
| Transitional cell carcinoma | D002295 | — | — | — | 1 | — | — | — | 1 |
| Chemotherapy-induced febrile neutropenia | D064146 | — | — | — | 1 | — | — | — | 1 |
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Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Esophageal squamous cell carcinoma | D000077277 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Trilaciclib |
| INN | trilaciclib |
| Description | Trilaciclib, sold under the brand name Cosela, is a medication used to reduce the frequency of chemotherapy-induced bone marrow suppression.
|
| Classification | Small molecule |
| Drug class | cyclin dependent kinase inhibitors (formerly-cidib) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN1CCN(c2ccc(Nc3ncc4cc5n(c4n3)C3(CCCCC3)CNC5=O)nc2)CC1 |
Identifiers
| PDB | — |
| CAS-ID | 1374743-00-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3894860 |
| ChEBI ID | — |
| PubChem CID | 68029831 |
| DrugBank | DB15442 |
| UNII ID | U6072DO9XG (ChemIDplus, GSRS) |
Target
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Financial
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Trends
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Additional graphs summarizing 419 documents
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Safety
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Adverse Events
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230 adverse events reported
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